PSY 315 Class Notes and Study Guides
PSY 315 Class Notes and Study Guides PSY 315 - M001
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This 172 page Bundle was uploaded by Allison Raymond on Tuesday May 10, 2016. The Bundle belongs to PSY 315 - M001 at Syracuse University taught by T. Palfai in Fall 2015. Since its upload, it has received 31 views. For similar materials see Drugs and Human Behavior in Psychlogy at Syracuse University.
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Date Created: 05/10/16
PSY 315 Exam 2 Review 2.24.16 Notes Extra reading in supplement Gina Felata – Theta Raises ethical issues Beyond pleasure principles Definition of neuron o Nerve v. tract o Ganglion o Nucleus Parts of cell and what they do Action potential, resting potential, etc. o Depolarization o Hyper polarization o Hypo polarization o SUMANASINC LINK!!! Ions involved in lipids through membrane o Na+ o Cl- o K+ o A- o What’s inside v. out, etc. Divisions of the nervous system o Sematic – brain and spinal cord o Autonomic = sympathetic and parasympathetic Spinal cord and differences with the sympathetic and parasympathetic o P – long pre-gang, short post o S – reverse o Grey matter, sensory v. motor nerves, ventral route, reflexes, dorsal root ganglion o Reflexes: ascending and descending Mono- di- and poly- The brain (functions) o Hindbrain Medulla Pons Cerebellum o Mid brain Tectum Tegmentum Reticular formation Substantia nigra Ventral tegmental area o Only places where dopamine is made o Forebrain Old Hypothalamus Thalamus Basal ganglia Limbic system and parts New Occipital lobe Parietal lobe Frontal Temporal Primary sensory and motor areas Broca’s area and Wernicke’s are Correlates of drug action o Synapse Axon, presynaptic terminal, knob, etc. o Otto Loewi, V Events at the synapse (!!!) o Reuptake, neurotransmitter, etc. Neurotransmitter criteria o Identification o Mechanism for synthesis, etc. Qualifiers o Acetylcholine o Serotonin o Dopamine o Noradrenaline, o GABA o Glutamate o Endorphins Analgesia, dependency, placebo and acupuncture Each synapse and transmitters! (see notes) EXAM QUESTIONS 1. Properties of resting membrane potential 2. Neurotrans in general 3. Action potential 4. Action potential 5. Division of autonomic nervous system 6. Sympathetic v. parasympathetic ns 7. Different types of receptors 8. Epinephrine in the brain (role) 9. Difference sematic and autonomic 10. Sympathetic v. para in chemistry 11. Function of sympathetic v. para 12. Types of colorgic? Receptors 13. Substancia niagra 14. Basil ganglia 15. Cerebellum 16. Fedella 17. mid brain 18. cortex (different lobes) 19. antagonist and agonists for systems 20. combination of drug effects in colergic system 21. LSD 22. Cocaine 23. Renshaw cell – radshaw 24. Different types of anergeric receptors 25. Enzyms breaking down neuro trans 26. Antagonists of c. system 27. Drug x and drug y produce y 28. Ottolergy 29. “ 30. role of GABA 31. article Kalata 32. article Kalata 33. given drug x and y, what will effect be 34. different criteria for neurot 35. given drug x and y, what will effect be 36. norolergic receptors 37. brain structure and function 38. difference slow and fast GABA uptake 39. other article 40. other article 41. given drug x and y, what will effect be 42. given drug x and y, what will effect be 43. glutamate 44. glutamate 45. ampa and NMDP receptors 46. nucleus accombance 47. colorgeric antagonists 48. AMPA receptor 49. If I inject drug x into site, what will happen 50. Termination for transmitters 51. Termination for transmitters 52. Termination for transmitters 53. Antagonists of outonergic receptors 54. GABA PSY 315 Exam 3 Questions I apologize for the spelling mistakes, he talks fast Reading: Laura Heluld Beyond the Principle Addicted to Anti-Depressants 1. Methods of treatment depression 2. Side effects of anti-depressant drugs 3. Problems with MAO inhibitors 4. Prozac 5. Treatment of mania 6. Trade name, brand name, genetic name 7. Free-basing (cocaine) 8. Trade name, brand name, genetic name 9. Benzodiazepines 10.Schedules of different drugs (textbook) 11.Symptoms of anxiety disorders 12.Application of propanediols (mephenesin, meprobamate) 13.Learned helplessness 14.Propanediols 15.Levels of alcohol intoxication 16.Mechanism of action of alcohol 17.Fetal alcohol syndrome 18.Alcohol 19.Fetal alcohol syndrome 20.Side effects of alcohol 21.Obituates 22.“ and effects on newborns 23.schizophrenia 24.extra pirimidal syndromes 25.tarded dyskinesia 26.cade ? 27.newer anti psychotics 28.shape veratical 29.shape veratical 30.shape veratical 31.mechanisms that underline schizophrenia 32.henry laborit – surgeon 33.side effects of schizophrenia treatments 34.article 35.article 36. anti-depressants 37.mechanism of action obiturates 38.“ of benzodiazepines 39.negative symptoms of schizophrenia 40.dopamine hypothesis of “ 41.Symptoms of anxiety disorders 42.Wikler model of Reinforcement 43.Abscenth and ingredients 44.Action of benzodiaphenes 45.Rohypnol 46.GHB 47. Preons 48.appendix Study Guide PSY 315 Week 3 Notes PSY 315 EXAM ONE REVIEW KEY TERMS TO PAY ATTENTION TO IN STUDY KEY IDEAS TO KNOW QUESTIONS • Blood-brain barrier • Direct and indirect agonists • Placental barrier • Direct and indirect antagonists • Cytochrome P450 • Excretion • Maximum effect • Non-specific effects • Response curves • Threshold response • Lipid v. water solubility • Placebo • Affinity • Ion trapping • Membrane characteristics • Drug potency PSY 315 EXAM ONE REVIEW KEY TERMS TO PAY ATTENTION TO IN STUDY QUESTIONS KEY IDEAS TO KNOW Blood-brain barrier Direct and indirect agonists Placental barrier Direct and indirect antagonists Cytochrome P450 Excretion Maximum effect Non-specific effects Response curves Threshold response Placebo Lipid v. water solubility Affinity Ion trapping Membrane characteristics Drug potency CLASS 1.25 NOTES 1.27 CLASS Important Information and Definitions 1/25 Class • There was a huge decrease in patients in mental hospitals following the use of psychoactive drugs • Agonist: any substance that is capable of activating the channel • Antagonist: any substance that interferes with activating the channel o Competitive: competes for receptor sites (blocks it) o Non-competitive: doesn’t affect receptor sites • Body compartments: the space enclosed by a membrane (drugs cross membrane to get to brain) • Ion trapping: o Polarized drugs will not be absorbed; drugs don’t ionize when the pH in its surroundings are the same (acidic or alkaline) o Aspirin (highly acidic), swallowed into stomach, doesn’t ionize, moves into blood quickly, in blood it will ionize and won’t get out of blood (b/c it ionized) • pH (alkaline v. acid): blood is alkaline and stomach is acidic Pros and Cons of Administrations Administration Pros Cons Oral Easy, economical, safe, can Slow absorption, sometimes digested administration recall the drug by vomiting before reach the site of action, reduced in effect due to metabolizatoin Injection (IV) Control dosage levels, short Can’t be recalled, more severe adverse delay in onset of effects reactions (IA) Control dosage, short delay in Pressure of the heartbeat, much more onset of effects, used to localize dangerous than IV a drug effect or dye a particular organ or tissue (IM) Rate faster than oral routes, Rate slower than IV, avoid hitting a blood vessel (SC) Reduces chance of hitting a Variations in blood supply may make vein, less painful than IM, the amount of the dose absorbed steady absorption rate erratic and unpredictable (IP) Dissolves evenly in the High risk of infection, placement is peritoneal fluid difficult, risk of puncturing the intestines (IT) Used for localized anesthesia (IC) Used for animal research Risk of injuring vital parts of the brain are high Inhalation Very fast absorption into Dosage control is difficult, they exit the bloodstream bloodstream quickly as well, must inhale drug for as long as the effect is desired Surface Ease of administration Absorption is slow and difficult Suppository Useful if a drug can’t withstand Absorption is somewhat incomplete the acid of gastric juices, or if and unpredictable patient is vomiting or unconscious 1/27 Class • conjugation: adding glucoronic acid • mixed function oxidases (MFO enzymes): o Heme: carries oxygen o Protein: attracts drugs • Enzyme induction: if you drink alcohol every day, enzyme levels adjust and increase; if you then stop drinking, the extra enzymes will eat up steroids until they re-adjust • Excretion principle organ: kidney o Functional unit: nephron artery, vein, Bowman’s capsule o Chorinic villai • Example questions on dosage: o How safe is LSD if ED99=0.05mg and the LD1=1.2g? o HTC=1.2g/.05mg= 24,000 o The dosage of LSD that kills 1% of people is 24,000 times higher than the dosage it takes to cause the desired effect in 99% of the people. LSD is a very safe drug. ACh Synapse DA Synapse NE Synapse 5-HT Synapse GABA Synapse GABA Receptors EXAM QUESTIONS 1. Properties of resting membrane 28. Otology potential 29. role of GABA 2. Neurotransmitters in general 30. article Kalata 3. Action potential 31. article Kalata 4. Action potential 5. Division of autonomic nervous system 32. given drug x and y, what will effect be 6. Sympathetic v. parasympathetic ns 33. different criteria for neurons 7. Different types of receptors 34. given drug x and y, what will 8. Epinephrine in the brain (role) effect be 9. Difference sematic and autonomic 35. neurologic receptors 10. Sympathetic v. parasympathetic in chemistry 36. brain structure and function 37. difference slow and fast GABA 11. Function of sympathetic v. uptake parasympathetic 38. other article 12. Types of ACl Receptors 39. other article 13. Substancia niagra 40. given drug x and y, what will 14. Basil ganglia 15. Cerebellum effect be 41. given drug x and y, what will 16. Medulla effect be 17. mid brain 42. glutamate 18. cortex (different lobes) 43. glutamate 19. antagonist and agonists for 44. AMPA and NMDP receptors systems 20. combination of drug effects 45. nucleus accombance 46. ACl antagonists 21. LSD 47. AMPA receptor 22. Cocaine 48. If I inject drug x into site, what 23. “ will happen 24. Different types of anergeric 49. Termination for transmitters receptors 50. Termination for transmitters 51. Termination for transmitters ACh Synapse DA Synapse NE Synapse 5-HT Synapse GABA Synapse GABA Receptors EXAM QUESTIONS 1. Properties of resting membrane potential 28. Otology 2. Neurotransmitters in general 29. role of GABA 3. Action potential 30. article Kalata 4. Action potential 5. Division of autonomic nervous system 31. article Kalata 32. given drug x and y, what will effect be 6. Sympathetic v. parasympathetic ns 33. different criteria for neurons 7. Different types of receptors 34. given drug x and y, what will effect be 8. Epinephrine in the brain (role) 35. neurologic receptors 9. Difference sematic and autonomic 36. brain structure and function 10. Sympathetic v. parasympathetic in chemistry 11. Function of sympathetic v. parasympathetic 37. difference slow and fast GABA uptake 38. other article 12. Types of ACl Receptors 39. other article 13. Substancia niagra 40. given drug x and y, what will effect be 14. Basil ganglia 41. given drug x and y, what will effect be 15. Cerebellum 42. glutamate 16. Medulla 17. mid brain 43. glutamate 44. AMPA and NMDP receptors 18. cortex (different lobes) 45. nucleus accombance 19. antagonist and agonists for systems 46. ACl antagonists 20. combination of drug effects 47. AMPA receptor 21. LSD 48. If I inject drug x into site, what will happen 22. Cocaine 49. Termination for transmitters 23. “ 50. Termination for transmitters 24. Different types of anergeric receptors 51. Termination for transmitters 25. Enzymes breaking down neurotransmitters 52. Antagonists of ACl receptors 26. Antagonists of c. system 53. GABA 27. Drug x and drug y produce y 30. “ PSY Study 31. “ 32. “ 33. pyotee 34. use of nicotine 35. use of cocaine Guide 36. Coughmann LSD - reading 37. “ Exam Questions 1. Mechanism of action of caffeine 2. Catastasis 3. Effect of opiates 4. Methadone 5. Application of amphetamines 38. THC 6. Mechanism of action of “ 39. Marijuana use 7. Long term effects of “ 40. Preparation of tea 41. Uses of zanteas 8. Type of “ 9. use of “ 42. Use of nicotine 10. application of 43. Effects of nicotine cocaine 44. Opiates 11. history of cocaine 45. Naloxone 12. ecstasy 46. Opiates 13. mech of action “ 47. “ 14. ecstasy 48. LSD metabolism 15. PCP 49. Anti cholinergic 16. Phencyclidine (PCP) 50. Magic mushroom 17. Effect of smoking 51. Method of using 18. 3 kinds of zantenes marijuana zenteens 52. Marijuana 19. fly agaric mushroom 53. Use of cocaine 20. cholergenic 54. Names of hallucinogens amphetamines 21. gyotee 55. Use of “ 22. urgot 56. Khat 23. LSD mech of action 57. Mechanism of action 24. DNT angel dust 25. Mesadone 58. Effects of marijuana 26. LSD 59. Chocolate 27. Ergots 60. Nicotine 28. History of opiates 61. Nicotine 29. Readings
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