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Module 3 Notes

by: Emily.nicole

Module 3 Notes BIO 305

GPA 4.0
Integrative Biology Lab
Dr. Mark Ritchie, Dr. Kate Lewis, & Dr. Eleanor Maine

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Module 3: C. Elegans by Professor Elanor Maine (EM) ---> weeks 11-14 12: (3/31) EM Lecture Introduction to Caenorhabditis elegans as a model system. Basic nematode biology, including life cy...
Integrative Biology Lab
Dr. Mark Ritchie, Dr. Kate Lewis, & Dr. Eleanor Maine
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This 3 page Bundle was uploaded by Emily.nicole on Thursday December 3, 2015. The Bundle belongs to BIO 305 at Syracuse University taught by Dr. Mark Ritchie, Dr. Kate Lewis, & Dr. Eleanor Maine in Spring 2014. Since its upload, it has received 70 views. For similar materials see Integrative Biology Lab in Biology at Syracuse University.


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Date Created: 12/03/15
C Elegans o A new model organism the nematode Caenorhabdis elegans o Germline development 0 Notchtype cell signaling 0 Regulation of development by genesamp environment 0 Links between gene expression amp disease 0 Characteristics 0 lives in the soil eats microbes o transparent internal structures are visible I pharynx intestine embryos tail 0 easy to raise in large s 0 short life cycle 0 amenable to gene analysis 0 Adult morphology o 5 autosomes X chromosome 0 Life cycle 0 embryo o Larval stages I L1 gtL2 gtL3 gtL4 Adult Environmental lnputs Alternative developmental pathway L2d 0 Biological processes studied in C elegans include o Mechanisms regulating gene expression I eg transcription and translation 0 Developmental mechanisms including o nervous system 0 organ formation 0 cellulardifferentiation 0 Regulatory mechanisms identified in C elegans include o Cellsignaling pathways 0 Apoptosisprogrammed cell death Our focus germ cells 0 Gametes develop from germ cells Germ cells as a tissue are called germ line NOT germ Layers 0 ALL others are considered somatic 0 Stem cells divide to replicate itself self renew amp to differentiate into different cell types 0 Balance is maintained between stem cells amp differentiated cells 0 Excess stem cells can tumor 0 Insufficient stem cells cannot replenish C elegans nomenclature 0 Gene name glp1 germline proliferation wildtype allele glp1 mutant allele glp1bn18 bn Strome lab at Indiana U in Bloomington IN Protein name GLP1 o GLP1 activity is necessary for maintaining germline stem cells Transmembrane receptor protein Notch family Made by germ cells Binds signal ligand on distal tip cell I highest concentration in mitotic cells I located on germ cell membranes GLP1NOTCH signaling induces germ cell proliferation during development Somatic cells express signal Germ cells express receptor 0000 0000 O 0000 Worm Breeding 1 Each hermaphrodite produces sperm oocytes amp embryos selfprogeny 2 Temperature sensitive ts mutations Phenotype depends on culture temperature Normal development at permissive temp Abnormal development at restrictive temp Maintain strain at permissive temp evaluate developmental defects at restrictive temp Week 12 1 Environmental impacts on development 0 development is buffered against extreme environmental fluctuations I UV 0 environment may be a normal agent for producing phenotype 0 environmental factors may produce disease 1 genetic events ie mutations may be triggered by outside agent 2 outside agents cause disease directly radiation some chemicals viruses bacteria 0 Physical abiotic 0 temperature osmotic pressure pressure amp gravity light 0 Biotic o diet amp nutrition population density maternal care predators symbiosis


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