Pharmacology - drug monitoring
Pharmacology - drug monitoring 1001
Leonard M. Miller School of Medicine
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This 2 page Study Guide was uploaded by Hanyao Foong on Monday January 4, 2016. The Study Guide belongs to 1001 at Leonard M. Miller School of Medicine taught by in Winter2015. Since its upload, it has received 46 views. For similar materials see Medcine in Military Science at Leonard M. Miller School of Medicine.
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Date Created: 01/04/16
Drug monitoring The tables below show the monitoring requirements of common drugs. It should be noted these are basic guidelines and do not relate to monitoring effectiveness of treatment (e.g. Checking lipids for patients taking a statin) Cardiovascular drugs Drug Main monitoring parameters Details of monitoring Statins LFT LFTs at baseline, 3 months and 12 months ACE inhibitors U&E U&E prior to treatment U&E after increasing dose U&E at least annually Amiodarone TFT, LFT TFT, LFT, U&E, CXR prior to treatment TFT, LFT every 6 months Rheumatology drugs Main monitoring Drug parameters Details of monitoring Methotrexate (MTX) FBC, LFT, The Committee on Safety of Medicines U&E recommend 'FBC and renal and LFTs before antimetabolite; Uses: starting treatment and repeated weekly until therapy stabilised, thereafter patients should be Cancers: leukaemias, monitored every 23 months' lymphomas, choriocarcinoma, sarcomas MTX SE: Myelosuppression, which is reversible with leucovorin (folinic acid) “rescue”; Nonneoplastic: abortion, macrovesicular fatty change in liver; mucositis ectopic pregnancy, rheumatoid (mouth ulcers); Teratogenic; pulmonary fibrosis arthritis, psoriatic arthritis, IBD, vasculitis Azathioprine FBC, LFT FBC, LFT before treatment FBC weekly for the first 4 weeks FBC, LFT every 3 months Neuropsychiatric drugs Main monitoring Drug parameters Details of monitoring Lithium Lithium level, TFT, U&E TFT, U&E prior to treatment Lithium levels weekly until stabilised then every 3 months TFT, U&E every 6 months Sodium LFT LFT, FBC before treatment valproate LFT 'periodically' during first 6 months Endocrine drugs Drug Main monitoring parameters Details of monitoring Glitazones LFT LFT before treatment LFT 'regularly' during treatment
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