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NUR 617: Table of Antibiotics Study Guide for test 1

by: Meghan Notetaker

NUR 617: Table of Antibiotics Study Guide for test 1 617

Marketplace > La Salle University > Nursing and Health Sciences > 617 > NUR 617 Table of Antibiotics Study Guide for test 1
Meghan Notetaker
La Salle

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About this Document

This is a table of antibiotics grouped together by class and mechanism of action. These antibiotics will be on test #1.
Dr. Joan Frizzell
Study Guide
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Popular in Pharmacology

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This 5 page Study Guide was uploaded by Meghan Notetaker on Friday February 12, 2016. The Study Guide belongs to 617 at La Salle University taught by Dr. Joan Frizzell in Winter 2016. Since its upload, it has received 25 views. For similar materials see Pharmacology in Nursing and Health Sciences at La Salle University.

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Date Created: 02/12/16
 ANTIBIOTICS Classification Name Mechanism of Action Indications Patient Care Issues Beta Lactam Penicillin Alters cell wall Staph & Strep Allergy, GI Symptoms,  Inhibits the formation of  Gonococcal inactivation of  peptidoglycan aminoglycosides Gram (+)  Bactericidal Activity decreased by  *Strep throat, tonsillitis, Tetracycline sinus infection, Ear  infection Probenecid delays  excretion of PCN Amoxicillin (Amoxil) Alters cell wall synthesis Extended Spectrum of  activity Susceptible to hydrolysis  by Beta Lactamases Gram (­)  *Ear infections, Skin or  dental infections, UTI,  Gonorrhea, Resp  infections Cloxacillin (Cloxapin) Alters cell wall synthesis Penicillinase Resistant Must be taken ‘round the  clock’ for 10 days. Clavulanic Acid Beta Lactamase inhibitor Take with Amox =  AUGMENTIN Cephalosporins First Generation Alters cell wall synthesis Primarily  Gram (+) Cross­reactivity with PCN  Classification Name Mechanism of Action Indications Patient Care Issues Cephalexin (Keflex) Inhibits the formation of  Respiratory Infections, GU allergy peptidoglycan and Otitis media Increased nephrotoxicity  when used with  Bactericidal aminoglycosides Increased Bleeding with  anticoagulants Disulfiram reaction with  ETOH Second Generation Alters cell wall synthesis Gram (+), some gram (­) Cefoxitin (Mefoxin) Inhibits the formation of  Some beta lactamase  peptidoglycan resistant Third Generation Alters cell wall synthesis Minimal Gram (+), mostly  Cefoxtamine  Inhibits the formation of  Gram (­) peptidoglycan (Claforan) More Beta lactamase  resistant Fourth Generation Alters cell wall synthesis All Gram (­) Cefepime Inhibits the formation of  All Beta Lactam resistant peptidoglycan Crosses BBB Broad Spectrum including  Cephalosporin resistant  Staph aureus and  Pseudomonas Beta Lactamase resistant No cross allergy to PCN Monobactam Aztreonam Inhibitor of cell wall  synthesis Binds to PBP Gram (­) rods, NO GPOS Classification Name Mechanism of Action Indications Patient Care Issues Admin IV Carbapenems  Meropenem Gram (+) including some  Partial cross allergy to  PCN resistant  PCNs pneumococci Gram (­) rods Low susceptibility to beta  Lactamases Beta Lactamase  Clavulanic Acid,  Used in fixed  Inhibitors  Sulbactam,  combinations with PCNs.  Tazobactam MRSA, C Diff, Gram (+) Renal failure, ototoxicity Other Vancomycin Binds to pentapeptide chain and inhibits  Redman syndrome transglycosylation Narrow spectrum of  Less risk of allergic  activity reactions. Prevents elongation  Used w/ 3  gen ceph for tx of infections due to PCN  of cross linking  resistant pneumococci  (PRSP) Macrolides Azithromycin Inhibition of CYP450 Used when PCN allergy Ototoxicity, statins increase (Zithromax) Gram (+), strep and  risk of myopathy,  Work near ribosomes/RNA pneumo, legionella, H  TOXICITY: azole  to prevent protein  pylori, H influenzae  antifungals, non­sedating  synthesis  antihistamines *sinus infection, gonorrhea as alternative to  ceftriaxone, or syphilis as  an alt to PCN G, CAP Classification Name Mechanism of Action Indications Patient Care Issues Inhibition of CYP450 Gram (+) Cholestatic Hepatitis,  Erythromycin statins increase risk of  Work near ribosomes/RNA myopathy, TOXICITY:  to prevent protein  azole antifungals, non­ synthesis sedating antihistamines Inhibition of CYP450 Statins increase risk of  Clarithromycin  myopathy, TOXICITY:  Work near ribosomes/RNA azole antifungals, non­ to prevent protein  sedating antihistamines synthesis Inhibits bacterial protein  Gram (+) cocci Clindamycin  Clindamycin synthesis Streptococci,  pneumococci Mylation of the biding site  on 50S ribosomal subunit Used to tx anaerobic  infections  Tetracyclines Doxycycline Used as alternative to  Excreted in feces, yellowing Bacteriostatic macrolides to tx CAP,GI  of teeth ulcers in H pylori Contraindicated in  Mycoplasma pneumonia,  pregnancy Acne Photosensitivity  Aminoglycosides  Streptomycin Bacterial inhibitors of  Used in combo with PCNs Ototoxicity, Nephrotoxic protein synthesis  Contraindicated in  Bind to 30S ribosomal  pregnancy subunit  Gentamicin,  Bacterial inhibitors of  Aerobic, Gram (­) Ototoxicity, Nephrotoxic Tobramycin protein synthesis  Used in combo with Beta  Contraindicated in  Bind to 30S ribosomal  Lactams to fight Gram (+) pregnancy subunit Classification Name Mechanism of Action Indications Patient Care Issues Antifolate Gram (+) and (­) May increase effects of  Sulfonamides  Bactrim, Sulfonyureas Warfarin Bacteriostatic inhibitors of *Simple UTI, Ulcerative  folic acid synthesis colitis, rheumatoid arthritis,Acute hemolysis in pts with  toxoplasmosis G6PD Fluoroquinolones  Ciproflaxin  Inhibits DNA replication Gram (­) Increased risk of tendonitis  (2  generation) or tendon rupture Save for tx of failed resp  infections  *UIT, infections of the skin, lungs, airway, bones Levofloxin  Inhibits DNA replication  Primarily Gram (+) Peripheral neuropathy,  (3  generation) increased blood sugar,  Respiratory, UTI, GI,  thrombocytopenia, ***Long  abdominal infections QT syndrome* Save for failed tx of  respiratory infection


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