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Cal Poly - BIOL 161 - Class Notes - Week 4

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Cal Poly - BIOL 161 - Class Notes - Week 4

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Join more than 18,000+ college students at California Polytechnic State University - San Luis Obispo who use StudySoup to get ahead
School: California Polytechnic State University - San Luis Obispo
Department: Biology
Course: Introduction to Cell and Molecular Biology
Professor: Amy Howes
Term: Winter 2016
Tags: Biology, bio161, Molecular, and, Cellular, notes, week, 3, Lipids, membrane, Proteins, active, passive, transport, Respiration, glycolysis, pyruvate, processing, krebs, citric, acid, cycle, Biological, sciences, CAl, poly, California, polytechnic, state, University, metabolism, pumps, channel, conformation, and C
Name: BIO 161 Week 3 Notes
Description: These notes finish up lipids (membrane proteins and active/passive transport) and dive into cellular respiration. The first 3 of 4 main steps are covered including Glycolysis, Pyruvate Processing, and the Krebs/Citric Acid Cycle..
Uploaded: 04/17/2016
2 Pages 56 Views 44 Unlocks
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Unformatted text preview: BIO 161 Week 3 NOTES (Pi) o finishing up lipids Pumps-Use energy to actively transport molecules against their concentration 9.dcidient - Active Transport - pumpmg that requires energy - There are conformati dhal changes in pumps as well as proteins fat facilitate diffusion.. - Pumps have selective exclusion due to protein specific * ALL transport proteins change Shape BUT Pumps require energy for their conformational change. Are lipids true' polu mers? - No: lipids spontaniously agregate and they do not have a 'COVALENT BOHOUholding the monomer (Phos pno- Lipids) togrinec (only hydrophobic interactions.. Types of lembrane proteins -Ehannel Proteins : con channels) 1 Ls aqua por ins speed up difusion of Hzo -> many channels are gated" t selective -Cartier Proteins - change Shape during transport process - Pumps (see a bove) Metabolism - the sum of all the chemical reactions in the bod- Ly catabolism - durerge used to breat things down) anabolism - building things up. metabolically) * enzymes help facilitate molecular Changes that would be unlikely to our under spontanious Conditions ENERGJI ain a molecule H = enthalpy ali molecules Store energy, total energy AH: Change iw enthalpy. Sum of bonds broren treformed LS > Auseable energy + A unusable energy AG (qibbs free Energy Temperaturze AS AS = en tropy change disorder ExGthermic. release A energy = -AH (AHLO Endothermic. energy Stred = +AH (AHC)BIO lol Week 3 NOTES CPg 2) 1st Law of Thermodynamics L> energy is not Created nor destroyed, only transformed transfered 2nd Lowot Thermodynamics Ls total entropi (AS) always increages in un SOLATED System Gibbs free-energy Change AG AG-AR-TAS negative AG = reaction is spontanious positive AG= reaction is non spontanious _ xoa AGD Spontanus Seroxats bell rolling down Paris non-spontanious Pushin a rock up a hill" AGSO Pnroy a nini Epost Picssrorista ar Overview of Cellular Respiration 1. Glycoly Si5 A parts, 2. Puruviate Processing cellular 3. Citric acid Cycle respiration 4. Electron Transport Chain 24-300 C3 H12O6 + 302 -> 6. CO2 +ATP + Heat Birle ner lots *AGLO however the run per Pyruvate GRT OF ATP is nonspontanious due Achyotion 1o activation energy Pnergy Ea Ea. Ea. ENZYMES - cellular respiration is dided by enzymes t enzymes help catalise reactions by loweriny activaton energy Insuo enzyme ATP AGAO wt enzyme loueried 1. Enzymes lower octivation energy 1. En ij mes couple reactions 3. Enaimes Phosproraldle mdecules (ded phosphate group) Ls by, coupling the breakdown of ATP(-AG) / formation of a produc+ (+ac- Thosphorylation-allows acte site to be opened and enzyme function * he remlyat d a prosphate group can ALSO lead 16 deactivation eregne/pucenaBIO 161 NOTES WEEK 3 (93) 15 CELLULAR RESPIRATION Slep 1 Glycolysis'. Mobilization of Sugar Last of 4 processes in Cellular, respiration > decurs in Cytosol: gal = mobilize Sugar (mahe bonds more ve sroven) I. meokite sugars 2. (leque G Carbon Sugar into 2 3 Carbon Sugars 3. Oxidation (breshing bonds -> clectrons will be reduced) 1. Mobilization of Sugar (Invest. 2. ATP) Glucose ( > Glucose - Co-Phosphate Fructose-6-Phasphale ATP op rearranged (nis enzyme ATD AOP J Catzen -> Fructose-1, 6-bis phosphate *Kincses -> phosphorylate Hexohinuses -> Specifically phosphorylate GIUCOSE ponavegoko e nosso (C. Goog munc ARIANE 0 ca...wo 1. Cleavage to form 1 3-Carbon Molecules Fructose 1, G-bisphosphate (lc) > Glyceraklehyde-3-phosphate (302 aka(G-3-P) ->Glyceraldehyde-3 - Phosphatale 3.0xidation (Gain 2 ATP for each G-3-P) . 6-3-Proxidised) > 1,3-bisphosphagin ogly cerute -->-*PVUUTEE (interionic phosphore) P: DE NAD A ATP (Step 2 and 45 calatoed by -> Phosonoglycerate Kivuse Ouernew. 2 ATP invested , LATP produced, 2 NADH pasien, 2. PVRUVATE PA e *Substrate level presenorylation = ADP - ATP Regulation of Glycolysis Feedback Inbibitioa - the presence of a product will inhibi+ an enzyme and stop prodaction of that product L> large quantities of ATP will inhibit Phospro fructokivase through dicerc inhibition *Altesteric Tabioshoo - Substrate binds to an area ofner than The achve site to change enzyme Shape + inhibit activity

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