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Tulane - CELL 2050 - Class Notes - Week 5

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Tulane - CELL 2050 - Class Notes - Week 5

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background image Tuesday, September 20, 2016 Exam I Review Exam Details  • multiple choice
• #2 pencil and calculator
• material from lecture, quiz, worked problems and readings
• test broken up into chapters 
• don’t focus on the end of chapter problems
• LOOK OVER QUIZZES - these are indicative of types of questions that will be on the exam
• comprehension questions: definition/concept
• application: solving problems
Chapter 2  • chromosome structure
• cell cycle: phases and checkpoints
• mitosis
• meiosis I and II
• sister chromatid separation
• know chromosome numbers and how they relate/change during different phases of mitosis  and meiosis I and II • ex: if you have 2 chromosomes, how many after metaphase of mitosis?
• ex: in anaphase I, if you start of will x chromosomes, how many centromeres? 
Chapter 3  • principle of segregation
• dominance
• how to work monohybrid and dihybrid crosses
• probability
• multiplication rule: probability of 2+ independent events taking place together • keyword: and
• ccDdEe x CcddEe - what portion will be ccddee?
• 1/2 cc* 1/2 dd* 1/4 ee = 1/16 • additive rule: probability of any one of 2+ mutually exclusive events  • keyword either/or • how to apply them with genetic crosses Chapter 4  • chromosomal sex determination systems: XX-XY, XX-XO, genic, environmental, etc • won’t ask which animals are which, but know what the differences are
• limpets likely on test!
• abnormal sex chromosome numbers: different syndromes
• Y chromosomes: SRY, androgen insensitivity, evolution
• X-linked dominant and recessive, Y-linked 
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background image Tuesday, September 20, 2016 • know how to do crosses with these traits • dosage compensation and X inactivation (Barr body) Chapter 5  • types of dominance • incomplete
• codominance
• penetrance (know how to calculate)
• expressivity
• lethal allele
• multiple alleles
• gene interaction: MEMORIZE RATIOS (only the covered ones)
• different types of epistasis and ratios
• BE ABLE TO INTERPRET SNAIL PIGMENTATION PROBLEM
• sex influenced vs sex limited
• cytoplasmic inheritance 
• how to identify? • genomic imprinting
• maternal effect: offspring’s phenotype determined by GENOTYPE of the mother (may not 
necessarily look the same as the mother) Chapter 6  • be able to figure out which type of trait by looking at pedigree
• be able to interpret info from the pedigree - ex: is individual II-3 homozygous or heterozygous?
Chapter 7  • independent assortment vs. linked • complete linkage - ALL recombinant
• independent assortment - 1:1:1:1 ratio
• linkage with some crossing over: 2 sets will be >50%, 2 sets will be <50%
• nonrecombinant vs. recombinant • LOOK AT GAMETES - phenotypes not always indicative of recombination • crossing over with linked genes • single, double and triple crossovers • allelic configuration: cis vs trans configuration • to determine configuration: • nonrecombinants are identical to parents by gate configuration - will be highest  number • with nonrecombinants, we know that ab gametes came from the homozygous  recessive parent, so we can disregard them • the ones that are left show the gametes of the other parent
• if the mutants are on the same chromosome, cis configuration
• if on different chromosomes, will be in trans configuration
• gene mapping and recombination frequencies • calculate and use to construct map 2

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School: Tulane University
Department: Biology
Course: Genetics
Professor: Meadows
Term: Fall 2016
Tags:
Name: Review Session Exam 1
Description: Review session notes
Uploaded: 09/19/2016
3 Pages 16 Views 12 Unlocks
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