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OSU - BIOLOGY 1113 - Class Notes - Week 5

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OSU - BIOLOGY 1113 - Class Notes - Week 5

School: Ohio State University
Department: Biology
Course: BIOLOGY 1113
Professor: Ball and Dr. Weinstein
Term: Summer 2015
Tags: Biology
Name: Biology 1113 Chapter 7 Notes
Description: These notes covers all class notes as well as tophat questions. The notes also include a book overview of chapter 7
Uploaded: 09/19/2016
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background image Concepts 7.1 - 7.5, pg. 125-138 Explain why the plasma membrane is referred to as a fluid mosaic Explain the various functions of membrane proteins Explain the differences between passive, facilitated and active transport Predict what will happen to a cell when it is placed in solutions of different tonicities Successful students will be able to: Learning Outcomes Plasma Membrane: The Moat of the Cell Wednesday, September 14, 2016 9:20 AM     Chapter 7 Page 1    
background image Plasma Membrane: Hydrophobic and hydrophilic ends What property allows them to easily form membranes? Phospholipids Lipids and Proteins Fluid structure with a variety of proteins embedded or attached to it Fluid Mosaic model What's it made of? Different types of cells contain different membrane proteins Nonpolar portion of protein extends into the hydrophobic interior of the bilayer Integral: embedded in the membrane Often interact with exposed surface of integral proteins Peripheral: loosely bound to surface of membrane 2 Major types: Transport Enzymatic activity Signal transduction Cell-cell recognition Intercellular joining Attachment to the cytoskeleton and extracellular matrix **Don't need to memorize these** Functions: Question: Which of the following is true of integral membrane proteins? All proteins have a tertiary structure They are mobile within the bilayer Answer: They are usually transmembrane proteins (a portion inside and outside) Question: In order for a protein to be embedded in the cell membrane it would have to be…
Answer: Both hydrophobic and hydrophilic
Membrane Proteins How liver cells distinguish themselves from muscle cells This is why you can't just give someone blood or a kidney How your body recognizes foreign invaders Necessary for cell-cell recognition Importance of Carbohydrates HIV can infect a cell that has a co-receptor (CCR5) on its surface, as in most people. Berlin patient - had leukemia and HIV, when he underwent a bone marrow transplant, the 
HIV was gone. This lead to the experimental research of modification of cells and the CCR5.
HIV cannot infect a cell lacking CCR5 on its surface, as in resistant individuals Role of Membrane Proteins in HIV Infection: How is traffic across the membrane regulated? Nonpolar molecules (hydrocarbons, CO2, O2) can cross easily Use transport proteins to cross membrane Ions and polar molecules are impeded by the hydrophobic interior of the membrane The membrane is selectively permeable All molecules can't just pass through whenever… Movement Across the Membrane Movement of any molecule Down its concentration gradient (from HIGH to LOW) Each substance moves down its OWN [] gradient Diffusion (Passive Transport) Ch.7 Lecture Notes Wednesday, September 14, 2016 9:22 AM     Chapter 7 Page 2    
background image Unaffected by [] of other substances Each substance moves down its OWN [] gradient Spontaneous (requires no energy) Osmosis = diffusion of WATER across a selectively permeable membrane No net movement, cell is stable Isotonic = environment same as the cell Water moves out of cell, cell shrivels Hypertonic = more solutes in environment Water moves into cell, cell swells (and may burst) Hypotonic = less solutes in environment Ability of a surrounding solution to cause a cell to gain/lose water Tonicity Composition of the lipid bilayer impedes the diffusion polar molecules and ions No energy required (High [] to Low []) Transport proteins help them diffuse passively across the membrane Provide door way through membrane Aquaporins transport 3 billion water molecules per second Channel Proteins Change shape to shuttle molecule across the membrane Cystinuria - defect in carrier protein that transports cysteine across membrane of kidney 
cells
Carrier Proteins Facilitated Diffusion Incredibly important for nervous system Movement of molecules against their [] gradient requires energy Uses carrier proteins Crucial for maintaining electrochemical gradients and membrane potential for nerve 
impulses
Ion pumps Uses the [] gradient created by an ATP-powered pump to power the transport of a molecule 
against it [] gradient
Cotransport Active Transport Requires energy Phagocytosis Pinocytosis Receptor-mediate endocytosis Endocytosis Allows large molecules and particles to enter the cell Bulk Transport ________________________________________________________________________     Chapter 7 Page 3    

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School: Ohio State University
Department: Biology
Course: BIOLOGY 1113
Professor: Ball and Dr. Weinstein
Term: Summer 2015
Tags: Biology
Name: Biology 1113 Chapter 7 Notes
Description: These notes covers all class notes as well as tophat questions. The notes also include a book overview of chapter 7
Uploaded: 09/19/2016
10 Pages 13 Views 10 Unlocks
  • Better Grades Guarantee
  • 24/7 Homework help
  • Notes, Study Guides, Flashcards + More!
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