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NIU - BIOL 308 - Class Notes - Week 8

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NIU - BIOL 308 - Class Notes - Week 8

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background image Lecture 7: Pedigree Analysis  “Goals of Pedigree Analysis” 1. Determine the mode of inheritance: dominance, recessive, partial  dominance, sex-linked, autosomal, mitochondrial, and maternal effect 2. Determine the probability of an affected offspring for a given cross Y-linked Inheritance  Traits on the Y chromosome are only found in males, never in females The fathers traits are passed to all sons Dominance is irrelevant: there is only 1 copy of each Y-linked gene 
(hemizygous) 
Mitochondrial Genes Mitochondrial are only inherited from the mother Females that have mitochondrial traits= her offspring inherit  Males that have mitochondrial traits= none of his offsprings inherit it Note: only 1 allele is present in each individual, so dominance isn’t an 
issue 
background image Outsider Rules In pedigree there are people whose parents are unknown called 
“outsiders”
Outsiders Rule Dominants Pedigree: affected outside are assumed to 
be heterozygotes 
Outsiders Rule Recessive Pedigree: unaffected (normal) outsiders are 
assumed to be homozygotes 
Both of these rules are derived from the observation that mutant 
alleles are rare 
Maternal Effect Genes “Mothers genotype determines offsprings phenotype” Assume that the traits is recessive in a complete dominance situation  Also assume all outsiders are homozygous for the allele they are 
expressing: the dominant allele is they are unaffected and the 
recessive allele if they are affected
Sex-Influenced Traits  Assume that the traits is dominant in male but recessive in females Assume all outsiders are homozygous:
-DD is always affected
-dd is always normal
-Dd is affected in males but normal in females

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School: Northern Illinois University
Department: Biology
Course: Genetics
Professor: M. Johns
Term: Summer 2016
Tags: Biology
Name: Lec 7 Bio 308
Description: Hello Everyone, here are Lecture 4 notes, they are color coded to make it easier to remember. Red- Important Info/Vocabs Green- Examples Purple-Keep in mind Blue-Side notes Hope these notes help you
Uploaded: 09/19/2016
6 Pages 7 Views 5 Unlocks
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