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UMD / Biology / MOCB 330 / What is a regulatory molecule with a shape?

What is a regulatory molecule with a shape?

What is a regulatory molecule with a shape?

Description

School: University of Maryland - College Park
Department: Biology
Course: Cell Biology and Physiology
Professor: Hadiya woodham
Term: Fall 2016
Tags: cellular biology
Cost: 25
Name: BSCI330 Notes 10/6
Description: Reaction coupling Proteins ATP/GTP Hydrolysis Glycolysis Cellular Metabolism
Uploaded: 10/11/2016
3 Pages 123 Views 0 Unlocks
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"}.lst-kix_5dza1olgbhul-2 > li:before{content:"■ "}ol.lst-kix_fk51vajcy08t-6.start{counter-reset:lst-ctn-kix_fk51vajcy08t-6 0}.lst-kix_5dza1olgbhul-1 > li:before{content:"○ "}.lst-kix_or159enhsnvd-2 > li{counter-increment:lst-ctn-kix_or159enhsnvd-2}ul.lst-kix_u9bmnq4u1sfa-0{list-style-type:none}.lst-kix_5dza1olgbhul-0 > li:before{content:"● "}.lst-kix_9eqzj2ky2xl-1 > li:before{content:"○ "}ol.lst-kix_yt4hvcr6dp0v-7{list-style-type:none}ol.lst-kix_yt4hvcr6dp0v-8{list-style-type:none}ol.lst-kix_yt4hvcr6dp0v-5{list-style-type:none}.lst-kix_9eqzj2ky2xl-0 > li:before{content:"● "}ol.lst-kix_yt4hvcr6dp0v-6{list-style-type:none}ol.lst-kix_yt4hvcr6dp0v-3{list-style-type:none}ul.lst-kix_u9bmnq4u1sfa-7{list-style-type:none}ol.lst-kix_yt4hvcr6dp0v-4{list-style-type:none}ul.lst-kix_u9bmnq4u1sfa-8{list-style-type:none}ol.lst-kix_yt4hvcr6dp0v-1{list-style-type:none}.lst-kix_fk51vajcy08t-2 > li{counter-increment:lst-ctn-kix_fk51vajcy08t-2}ul.lst-kix_u9bmnq4u1sfa-5{list-style-type:none}.lst-kix_9eqzj2ky2xl-5 > li:before{content:"■ "}.lst-kix_9eqzj2ky2xl-7 > li:before{content:"○ "}ol.lst-kix_yt4hvcr6dp0v-2{list-style-type:none}ul.lst-kix_u9bmnq4u1sfa-6{list-style-type:none}ul.lst-kix_u9bmnq4u1sfa-3{list-style-type:none}ol.lst-kix_yt4hvcr6dp0v-0{list-style-type:none}ul.lst-kix_u9bmnq4u1sfa-4{list-style-type:none}ul.lst-kix_u9bmnq4u1sfa-1{list-style-type:none}.lst-kix_9eqzj2ky2xl-2 > li:before{content:"■ "}.lst-kix_9eqzj2ky2xl-6 > li:before{content:"● "}ul.lst-kix_u9bmnq4u1sfa-2{list-style-type:none}.lst-kix_9eqzj2ky2xl-3 > li:before{content:"● "}.lst-kix_yt4hvcr6dp0v-1 > li{counter-increment:lst-ctn-kix_yt4hvcr6dp0v-1}ol.lst-kix_fk51vajcy08t-3.start{counter-reset:lst-ctn-kix_fk51vajcy08t-3 0}.lst-kix_u9bmnq4u1sfa-0 > li:before{content:"● "}.lst-kix_9eqzj2ky2xl-4 > li:before{content:"○ "}.lst-kix_yt4hvcr6dp0v-4 > li{counter-increment:lst-ctn-kix_yt4hvcr6dp0v-4}.lst-kix_n1kmiyo31j01-1 > li:before{content:"○ "}.lst-kix_u9bmnq4u1sfa-1 > li:before{content:"○ "}.lst-kix_n1kmiyo31j01-0 > li:before{content:"● "}.lst-kix_n1kmiyo31j01-2 > li:before{content:"■ "}.lst-kix_u9bmnq4u1sfa-3 > li:before{content:"● "}.lst-kix_u9bmnq4u1sfa-2 > li:before{content:"■ "}.lst-kix_u9bmnq4u1sfa-5 > li:before{content:"■ "}.lst-kix_n1kmiyo31j01-4 > li:before{content:"○ "}.lst-kix_n1kmiyo31j01-3 > li:before{content:"● "}.lst-kix_u9bmnq4u1sfa-4 > li:before{content:"○ "}.lst-kix_n1kmiyo31j01-8 > li:before{content:"■ "}.lst-kix_yt4hvcr6dp0v-5 > li{counter-increment:lst-ctn-kix_yt4hvcr6dp0v-5}.lst-kix_u9bmnq4u1sfa-7 > li:before{content:"○ "}ol.lst-kix_or159enhsnvd-1.start{counter-reset:lst-ctn-kix_or159enhsnvd-1 0}.lst-kix_u9bmnq4u1sfa-6 > li:before{content:"● "}ol.lst-kix_or159enhsnvd-8.start{counter-reset:lst-ctn-kix_or159enhsnvd-8 0}ol.lst-kix_fk51vajcy08t-2.start{counter-reset:lst-ctn-kix_fk51vajcy08t-2 0}.lst-kix_n1kmiyo31j01-5 > li:before{content:"■ "}.lst-kix_n1kmiyo31j01-6 > li:before{content:"● "}.lst-kix_n1kmiyo31j01-7 > li:before{content:"○ "}.lst-kix_or159enhsnvd-3 > li{counter-increment:lst-ctn-kix_or159enhsnvd-3}.lst-kix_u9bmnq4u1sfa-8 > li:before{content:"■ "}ol.lst-kix_or159enhsnvd-0.start{counter-reset:lst-ctn-kix_or159enhsnvd-0 0}.lst-kix_fk51vajcy08t-4 > li{counter-increment:lst-ctn-kix_fk51vajcy08t-4}ol.lst-kix_fk51vajcy08t-1.start{counter-reset:lst-ctn-kix_fk51vajcy08t-1 0}.lst-kix_fk51vajcy08t-7 > li{counter-increment:lst-ctn-kix_fk51vajcy08t-7}.lst-kix_yt4hvcr6dp0v-8 > li{counter-increment:lst-ctn-kix_yt4hvcr6dp0v-8}.lst-kix_fk51vajcy08t-1 > li{counter-increment:lst-ctn-kix_fk51vajcy08t-1}ol.lst-kix_fk51vajcy08t-8.start{counter-reset:lst-ctn-kix_fk51vajcy08t-8 0}ol.lst-kix_or159enhsnvd-7.start{counter-reset:lst-ctn-kix_or159enhsnvd-7 0}ol.lst-kix_yt4hvcr6dp0v-4.start{counter-reset:lst-ctn-kix_yt4hvcr6dp0v-4 0}

AllostericDon't forget about the age old question of How does the supercoiling of DNA happen?

Regulator is a regulatory molecule w. A shape

BSC1330 Lecture

Proteins can act as molecular motors

  • Shape changes in protein → movement
  • Movement must be directional for it to be useful

Don't forget about the age old question of david lange uiuc

Solution: couple shape change in 1 direction w/ ATP hydrolysis

ATP → ADP + P1 = favorableWe also discuss several other topics like After the death of Aristotle & Alexander the Great, there were four major schools of philosophy in Athens. What are those?

ADP + P1 → ATP = unfavorable

Hydrolysis creates 2nd shape change to move forwardIf you want to learn more check out bu cs210
If you want to learn more check out What does the word "turgid" denote in animal cells?

We also discuss several other topics like Cite the three steps in chromosomal replication.

Proteins can act as molecular pumps

  • The ability to transport molecules across membranes is an essential properties
  1. Take nutrients
  2. Export waste
  3. Receive / send signals

Proteins embedded in cell membranes can harness energy from

  1. ATP / GTP hydrolysis
  2. Movement of ions
  3. Transfer of high E e-
  4. Pump substances in / out of cell or organelles

Why would energy be required to pump materials across the cell membrane?

Selective channels and pores

Ex: ABC transporters

Quaternary structure: 4 subunits

Class of membrane pumps that: export hydrophobic molecules out of the cell in Euk, import nutrients in bacteria

Hydrolysis of ATP → conformational change allowing molecules to move across membrane

Cellular metabolism

  • E for cellular processes comes from the chemical breakdown (catabolism) of nutrients
  • E is harvested by sugars and nutrients are oxidized in small, enzyme - catalyzed steps
  • This avoids the release of large quantities of A and reduces the activation E
  • Enzymes allow energetically unfavorable rxns to occur by coupling w/ energetically favorable rxns

The coupling of energetically favorable rxns w/ unfavorable ones is carried out by ENZYMES

Glycolysis

1 molecule of glucose → 2 molecules of pyruvate with a net product of 2 ATP and 2 NADH molecules - occurs in cytosol

3 phases

  1. Investment: 2 ATP are spent to activate glucose
  2. Cleavage: glucose is split into 2 3- carbon sugar
  3. Energy Generation: 4 ATP molecules

Formation of NADH and ATP are energetically unfavorable rxns

*the oxidation of G3P is favorable and this rxn releases sufficient E to drive other 2

“Substrate - level phosphorylation”

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