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Clemson - BIOL 4610 - Study Guide - Midterm

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Clemson - BIOL 4610 - Study Guide - Midterm

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background image Exam 3 Study Guide Dr. Chapman Cell Biology Clemson University
background image Microfilament (Actin) Based Motility Characteristics/Facts Don’t have to know the different myosins, only myosin 2 24 classes of Myosins Myosins exert force on microfilaments All are positive ended motors o Except Myosin 6 is a negative ended motor Functions Muscle contraction Cell movement Phagocytosis Vesicle transport Structure (Myosin 2) 2 heavy chains, with a globular head group with a tail  Essential Light Chain and Regulatory Light Chain (plays a role in regulating 
ATPase)
Actin Binding Site ATP Binding Site Figure 1:http://oregonstate.edu/instruction/bi314/summer09/cytoskel.html Figure 2: http://rsif.royalsocietypublishing.org/content/11/95/20131072
background image Movement ATP forms cross bridges The process (Sliding filament model) (Myosin 2) Figure 3: http://humanbiologylab.pbworks.com/w/page/60230004/Muscle%20Contraction%20And %20How%20It%20Works REMEMBER!!!!! ACTIN AND MYOSIN DO NOT CHANGE LENGTH!!! THEY DON NOT CHANGE STRUCTURE EITHER. ONLY POSITION EVERY STEP = 1 ATP
background image Organization of the Muscle Figure 4http://www.slideteam.net/0814-organization-of-cytoskeletal-and-my-filament-elements-in- smooth-muscle-medical-images-for-powerpoint.html In Words: MuscleBundle of Muscle FibersMuscle FiberMyofibrilSacromere (Between 2 Z 
discs)
Notes about muscular system: Thick Filiments o Myonesis joins two back ends of myosin together
background image Figure 5: Thin Filiments o Stucture: This is composed of F actini  filiment arranged in a rope like 
fashion 
Tropomyosin: This binds the myosin binding site and prevents 
myosin binding
troponin: Is what puls torpomyosin off of the binding site when 
Ca contrations are high
o Proteins associated with Thin Filments: α-actinin  keeps actin into parallel arrays CapZ  binds the plus and makes sure the plus stays bound to the  z line and stays together Tropomodulin  binds the minus ends of the filaments for stability,  nebulin  stabilizes the thin filaments all togehter Figure 6: o Organization of Muscle Filiment Proteins  

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School: Clemson University
Department: Biology
Course: Cell Biology
Professor: Susan Chapman
Term: Fall 2016
Tags: neuroscience, celljunctions, Muscles, and ECM
Name: Exam 3 Study Guide
Description: This is a very in depth study guide that has notes on all chapters as well as helpful diagrams and outside research. For the Junctions portion of the exam, there is a large in depth table that will help compare, contrast, and sort.
Uploaded: 10/30/2016
25 Pages 108 Views 86 Unlocks
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