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UGA / Biochemistry and Molecular Biology / BCMB 3100 / What is the significance of James Sumner?

What is the significance of James Sumner?

What is the significance of James Sumner?

Description

School: University of Georgia
Department: Biochemistry and Molecular Biology
Course: Introductory Biochemistry and Molecular Biology
Professor: Wood sabatini
Term: Fall 2016
Tags: Enzymes, Thermodynamics, energetics, and reactions
Cost: 50
Name: Quiz 5- enzymes, thermodynamics, energetics, reaction rate
Description: enzymes, thermodynamics, energetics, reaction rate
Uploaded: 12/14/2016
5 Pages 194 Views 1 Unlocks
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"}.lst-kix_h116i8bhhpe2-2 > li{counter-increment:lst-ctn-kix_h116i8bhhpe2-2}.lst-kix_qru9y8h0atj6-3 > li:before{content:"- "}.lst-kix_mj8ajdm0yem5-2 > li:before{content:"- "}ul.lst-kix_mj8ajdm0yem5-8{list-style-type:none}ul.lst-kix_mj8ajdm0yem5-7{list-style-type:none}ul.lst-kix_mj8ajdm0yem5-6{list-style-type:none}ul.lst-kix_mj8ajdm0yem5-5{list-style-type:none}.lst-kix_mj8ajdm0yem5-0 > li:before{content:"- "}.lst-kix_mj8ajdm0yem5-4 > li:before{content:"- "}ul.lst-kix_mj8ajdm0yem5-4{list-style-type:none}.lst-kix_po1jgw4c4sah-7 > li:before{content:"- "}ul.lst-kix_mj8ajdm0yem5-3{list-style-type:none}ul.lst-kix_mj8ajdm0yem5-2{list-style-type:none}.lst-kix_qru9y8h0atj6-5 > li:before{content:"- "}ul.lst-kix_mj8ajdm0yem5-1{list-style-type:none}ul.lst-kix_mj8ajdm0yem5-0{list-style-type:none}ol.lst-kix_h116i8bhhpe2-3.start{counter-reset:lst-ctn-kix_h116i8bhhpe2-3 0}.lst-kix_edql13j4o50r-3 > li:before{content:"- "}.lst-kix_qru9y8h0atj6-7 > li:before{content:"- "}.lst-kix_h116i8bhhpe2-1 > li{counter-increment:lst-ctn-kix_h116i8bhhpe2-1}.lst-kix_po1jgw4c4sah-1 > li:before{content:"- "}.lst-kix_otnmfilgqh4h-1 > li:before{content:"- "}.lst-kix_edql13j4o50r-5 > li:before{content:"- "}.lst-kix_edql13j4o50r-7 > li:before{content:"- "}.lst-kix_c5txze3n48yu-8 > li:before{content:"- "}.lst-kix_mj8ajdm0yem5-8 > li:before{content:"- "}ol.lst-kix_h116i8bhhpe2-0.start{counter-reset:lst-ctn-kix_h116i8bhhpe2-0 0}.lst-kix_po1jgw4c4sah-3 > li:before{content:"- "}.lst-kix_mj8ajdm0yem5-6 > li:before{content:"- "}.lst-kix_po1jgw4c4sah-5 > li:before{content:"- "}.lst-kix_y2af8a4neni4-5 > li:before{content:"- "}.lst-kix_qru9y8h0atj6-1 > li:before{content:"- "}.lst-kix_o6nm5f6fhddf-7 > li:before{content:"- "}ul.lst-kix_po1jgw4c4sah-7{list-style-type:none}ul.lst-kix_po1jgw4c4sah-6{list-style-type:none}ul.lst-kix_po1jgw4c4sah-5{list-style-type:none}ul.lst-kix_po1jgw4c4sah-4{list-style-type:none}.lst-kix_y2af8a4neni4-3 > li:before{content:"- 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0}ul.lst-kix_qru9y8h0atj6-1{list-style-type:none}ul.lst-kix_qru9y8h0atj6-0{list-style-type:none}ul.lst-kix_qru9y8h0atj6-3{list-style-type:none}ul.lst-kix_qru9y8h0atj6-2{list-style-type:none}ul.lst-kix_qru9y8h0atj6-5{list-style-type:none}ul.lst-kix_qru9y8h0atj6-4{list-style-type:none}ul.lst-kix_o6nm5f6fhddf-8{list-style-type:none}ul.lst-kix_o6nm5f6fhddf-7{list-style-type:none}ul.lst-kix_o6nm5f6fhddf-6{list-style-type:none}ul.lst-kix_o6nm5f6fhddf-5{list-style-type:none}ul.lst-kix_o6nm5f6fhddf-4{list-style-type:none}ul.lst-kix_qru9y8h0atj6-7{list-style-type:none}.lst-kix_y2af8a4neni4-1 > li:before{content:"- "}ul.lst-kix_o6nm5f6fhddf-3{list-style-type:none}ul.lst-kix_qru9y8h0atj6-6{list-style-type:none}ul.lst-kix_o6nm5f6fhddf-2{list-style-type:none}.lst-kix_h116i8bhhpe2-8 > li{counter-increment:lst-ctn-kix_h116i8bhhpe2-8}ul.lst-kix_o6nm5f6fhddf-1{list-style-type:none}ul.lst-kix_qru9y8h0atj6-8{list-style-type:none}ul.lst-kix_o6nm5f6fhddf-0{list-style-type:none}.lst-kix_y2af8a4neni4-0 > li:before{content:"- "}ul.lst-kix_y2af8a4neni4-8{list-style-type:none}ul.lst-kix_edql13j4o50r-5{list-style-type:none}ul.lst-kix_edql13j4o50r-6{list-style-type:none}ul.lst-kix_edql13j4o50r-3{list-style-type:none}ul.lst-kix_edql13j4o50r-4{list-style-type:none}ul.lst-kix_y2af8a4neni4-4{list-style-type:none}ul.lst-kix_y2af8a4neni4-5{list-style-type:none}ul.lst-kix_y2af8a4neni4-6{list-style-type:none}ul.lst-kix_edql13j4o50r-7{list-style-type:none}ul.lst-kix_y2af8a4neni4-7{list-style-type:none}ul.lst-kix_edql13j4o50r-8{list-style-type:none}ul.lst-kix_y2af8a4neni4-0{list-style-type:none}ul.lst-kix_y2af8a4neni4-1{list-style-type:none}ul.lst-kix_y2af8a4neni4-2{list-style-type:none}ul.lst-kix_y2af8a4neni4-3{list-style-type:none}.lst-kix_edql13j4o50r-1 > li:before{content:"- "}ul.lst-kix_edql13j4o50r-1{list-style-type:none}ul.lst-kix_edql13j4o50r-2{list-style-type:none}.lst-kix_edql13j4o50r-0 > li:before{content:"- "}ul.lst-kix_edql13j4o50r-0{list-style-type:none}ul.lst-kix_xnj61yhusc15-7{list-style-type:none}ul.lst-kix_xnj61yhusc15-6{list-style-type:none}ul.lst-kix_xnj61yhusc15-8{list-style-type:none}ol.lst-kix_h116i8bhhpe2-5.start{counter-reset:lst-ctn-kix_h116i8bhhpe2-5 0}.lst-kix_h116i8bhhpe2-6 > li{counter-increment:lst-ctn-kix_h116i8bhhpe2-6}ul.lst-kix_n3uuivn7p8hw-4{list-style-type:none}ul.lst-kix_n3uuivn7p8hw-3{list-style-type:none}ul.lst-kix_n3uuivn7p8hw-6{list-style-type:none}ul.lst-kix_n3uuivn7p8hw-5{list-style-type:none}ul.lst-kix_n3uuivn7p8hw-0{list-style-type:none}ul.lst-kix_n3uuivn7p8hw-2{list-style-type:none}ul.lst-kix_n3uuivn7p8hw-1{list-style-type:none}ul.lst-kix_xnj61yhusc15-1{list-style-type:none}ul.lst-kix_xnj61yhusc15-0{list-style-type:none}ul.lst-kix_n3uuivn7p8hw-8{list-style-type:none}ul.lst-kix_xnj61yhusc15-3{list-style-type:none}ul.lst-kix_n3uuivn7p8hw-7{list-style-type:none}ul.lst-kix_xnj61yhusc15-2{list-style-type:none}ul.lst-kix_xnj61yhusc15-5{list-style-type:none}ul.lst-kix_xnj61yhusc15-4{list-style-type:none}.lst-kix_h116i8bhhpe2-4 > li:before{content:"" counter(lst-ctn-kix_h116i8bhhpe2-4,lower-latin) ". 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"}.lst-kix_c5txze3n48yu-7 > li:before{content:"- "}.lst-kix_nnjbhi34m6r9-2 > li:before{content:"- "}.lst-kix_po1jgw4c4sah-0 > li:before{content:"- "}.lst-kix_otnmfilgqh4h-4 > li:before{content:"- "}ol.lst-kix_h116i8bhhpe2-7{list-style-type:none}ol.lst-kix_h116i8bhhpe2-8{list-style-type:none}.lst-kix_nnjbhi34m6r9-0 > li:before{content:"- "}.lst-kix_otnmfilgqh4h-6 > li:before{content:"- "}ol.lst-kix_h116i8bhhpe2-5{list-style-type:none}ol.lst-kix_h116i8bhhpe2-6{list-style-type:none}ol.lst-kix_h116i8bhhpe2-3{list-style-type:none}.lst-kix_qru9y8h0atj6-4 > li:before{content:"- "}ol.lst-kix_h116i8bhhpe2-4{list-style-type:none}ol.lst-kix_h116i8bhhpe2-1{list-style-type:none}.lst-kix_h116i8bhhpe2-6 > li:before{content:"" counter(lst-ctn-kix_h116i8bhhpe2-6,decimal) ". "}ol.lst-kix_h116i8bhhpe2-2{list-style-type:none}.lst-kix_c5txze3n48yu-3 > li:before{content:"- "}ol.lst-kix_h116i8bhhpe2-0{list-style-type:none}.lst-kix_po1jgw4c4sah-8 > li:before{content:"- "}.lst-kix_mj8ajdm0yem5-3 > li:before{content:"- "}.lst-kix_edql13j4o50r-2 > li:before{content:"- "}.lst-kix_qru9y8h0atj6-6 > li:before{content:"- "}.lst-kix_po1jgw4c4sah-2 > li:before{content:"- "}.lst-kix_mj8ajdm0yem5-1 > li:before{content:"- "}.lst-kix_edql13j4o50r-4 > li:before{content:"- "}.lst-kix_otnmfilgqh4h-2 > li:before{content:"- "}.lst-kix_h116i8bhhpe2-4 > li{counter-increment:lst-ctn-kix_h116i8bhhpe2-4}.lst-kix_qru9y8h0atj6-8 > li:before{content:"- "}.lst-kix_otnmfilgqh4h-0 > li:before{content:"- "}.lst-kix_mj8ajdm0yem5-7 > li:before{content:"- "}.lst-kix_edql13j4o50r-6 > li:before{content:"- "}.lst-kix_po1jgw4c4sah-4 > li:before{content:"- "}.lst-kix_po1jgw4c4sah-6 > li:before{content:"- "}.lst-kix_mj8ajdm0yem5-5 > li:before{content:"- "}.lst-kix_edql13j4o50r-8 > li:before{content:"- "}ul.lst-kix_otnmfilgqh4h-6{list-style-type:none}ul.lst-kix_otnmfilgqh4h-7{list-style-type:none}ul.lst-kix_otnmfilgqh4h-4{list-style-type:none}.lst-kix_o6nm5f6fhddf-0 > li:before{content:"- "}ul.lst-kix_otnmfilgqh4h-5{list-style-type:none}ul.lst-kix_otnmfilgqh4h-8{list-style-type:none}ul.lst-kix_otnmfilgqh4h-2{list-style-type:none}ul.lst-kix_otnmfilgqh4h-3{list-style-type:none}ul.lst-kix_otnmfilgqh4h-0{list-style-type:none}ul.lst-kix_otnmfilgqh4h-1{list-style-type:none}.lst-kix_h116i8bhhpe2-5 > li{counter-increment:lst-ctn-kix_h116i8bhhpe2-5}.lst-kix_qru9y8h0atj6-0 > li:before{content:"- "}.lst-kix_qru9y8h0atj6-2 > li:before{content:"- "}.lst-kix_otnmfilgqh4h-8 > li:before{content:"- "}.lst-kix_y2af8a4neni4-2 > li:before{content:"- "}.lst-kix_y2af8a4neni4-6 > li:before{content:"- "}.lst-kix_o6nm5f6fhddf-6 > li:before{content:"- "}.lst-kix_o6nm5f6fhddf-8 > li:before{content:"- "}.lst-kix_y2af8a4neni4-4 > li:before{content:"- "}ol.lst-kix_h116i8bhhpe2-8.start{counter-reset:lst-ctn-kix_h116i8bhhpe2-8 0}.lst-kix_o6nm5f6fhddf-2 > li:before{content:"- "}.lst-kix_o6nm5f6fhddf-4 > li:before{content:"- "}.lst-kix_y2af8a4neni4-8 > li:before{content:"- "}

Quiz 5

  1. Significance of James Summer coming in his lab at Cornell on that cold winter morning and spotting glistening crystals?
  • He successfully purified the enzyme increase and could then prove that enzymes are proteins
  1. Do enzymes make rxns favorable? Do they affect the key?
  • Enzymes increase rxn rate by lowering the activation energy of the transition state and increasing collision frequency
  • Do Not affect favorability of a rxn
  • Decrease A.E. in Both directions
  1. Role of H2SO4 in Kirchoff’s hydrolysis of starch? Difference between Benzellius definition of a catalyst and modern definition?
  • H2SO4 was catalyst in hydrolysis of starch
  • B: substance necessary for rxn, but not consumed by it
  • Modern: accelerates rxn, but not consumed
  1. What limits the rate of a rxn?
  • EA of the transition state
  • EA measure of instability of the trans. State (strained, unstable)
  1. Why do we use initial velocities in steady - state Kinetics?
  • Ignore reverse rxn and we don’t need to measure [S]
  • At early time points,

  1. Why do progress curves plateau?
  • At equilibrium
  • Ran out of substrate
  • Rate goes to zero at equilibrium at asymptotes when K,[S] = K-1[P] = 0
  • You don’t run out of S at eq.
  1. Why can we ignore the reverse rxn in Henri;s equation for Enzyme Catalysis?
  • At imte close to zero, there is not much product being made, so rxn =K1[S] - K-1[P]
  • Can be simplified to = Vo = K1[S]
  • So slope = K[S] = V0
  1. What’s the order of an enzyme rxn at high [S[?
  • Zero - order b/c increase [S] means enzymes are saturated and limited by turnover

  1. What does the rectangular hyperbola mean for a substrate saturation wave?
  • The plateau indicates zero - order: the velocity does not depend on the substrate. This means the rxn involves a saturable catalyst
  • [S] so high there are no free sites
  1. Fischer termed “lock the key” for what?
  • Lock is enzyme, key is substrate
  • Explains substrate specificity: specific enzyme has a specific function w/ a specific substrate
  1. Brown and Henri expanded on this to invoke what kind of complex? What evidence?
  • Used hyperbolic rate curve to support their hypothesis of the ES complex
  • ES complex is fully saturated at Vmax - limited by turnover
  • ES complex binds substrates to form product or fall apart
  1. What is Vmas? What is Kcat? “Diffusion limited”?
  • Vmax: ES fully saturated
  • Kcat:  K2 # of molecules of substrate converted per sec
  • DL: how fast a  substrate can diffuse to ES only limited when K2 is high
  • Vmax = K2[E] totals Km =
  1. What does Km tell you about an enzyme? Given K1, K-1, and K2, be able to calculate Km. predict what happens if a constant ↑ / ↓
  • Km =
  • Km is a measure of apparent attraction between E and S, and it describes how E affects collision frequency. As Km↓, affinity for S↑
  • ↓Km = ↑ stable ES complex
  • Km = ammt. Of substrate that saturated, 60% of E

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