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UGA / Biochemistry and Molecular Biology / BCMB 3100 / Why does HbF have a different affinity for oxygen relative to HbA?

Why does HbF have a different affinity for oxygen relative to HbA?

Why does HbF have a different affinity for oxygen relative to HbA?

Description

School: University of Georgia
Department: Biochemistry and Molecular Biology
Course: Introductory Biochemistry and Molecular Biology
Professor: Wood sabatini
Term: Fall 2016
Tags: fetal, Hemoglobin, and Carbohydrates
Cost: 50
Name: Quiz 6- fetal hemoglobin in Sickle Cell disease, carbohydrates
Description: fetal hemoglobin in Sickle Cell disease, carbohydrates
Uploaded: 12/14/2016
5 Pages 195 Views 1 Unlocks
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Quiz 6

  1. How does H2M mech use SN2 to retain stereochem?

2 consecutive SN2 steps

  1. SN2 mechanism of HEWL

If you want to learn more check out What is Napoleon Bonaparte's importance?

  1. Why does HbF have a different affinity for oxygen relative to HbA

HbF must have a high affinity for oxygen since the placenta is a slightly acidic, low oxygen environment, substitution of serine for histidine in the Y chain of the 2,3 - BPG binding site reduces HbF’s affinity for 2,3 - BPG, meaning the oxygen - binding affinity of HbF > HbA

  1. What observation led Pauling to deduce sickle cell was a molecular disease?
  • Arterial (oxygenated blood) had few sickles
  • Venous (deoxygenated, acidic blood) had many sickles
  1. How did Pauling prove there was a chemical defect in HbS?
  • Looking at isoelectric points, he saw at pH 6.9, HbA was slightly (-) and HbS was slightly (+)
  • Shows there is a chemical change in HbS. HbS either lost an acid or gained a base
  • One point mutation in B chain changes glutamic acid (E) → valine (V) “lost an acid”
  • Valine is hydrophobic, so unlike hydrophilic E, it avoids water and sticks in hydrophobic pocket in T - state: sickling
  1. How does HbF affect sickle cell?
  • HbF favors R - sickle, you need 15 - 30%, HbF to keep RBC’s in R - state
  • HbF will not participate in fiber formation (T - state)
  1. In the formation of sickling fibers driven by enthalpy of enthalpy?

Entropy - since hydrophobic valine sticks in pocket, it is avoiding the need for clathrates, which would 1 entropy

  1. Glucose: 24 = 16 isomers

Don't forget about the age old question of psych 211

We also discuss several other topics like Which term refers to when producers of mass media use mass media to perpetuate values and ideas that are consistent with the status quo?

  • Glucose - primary fuel for lining cells. Main source for brain building block of cellulose, starch, and glycogen
  • Fructose - ketohexose isomer of glucose, fruit sugar. 2x sweeter
  • Galactose - epimer of glucose. Needed for glycolipids / proteins

We also discuss several other topics like tariffs reallocate income from

Role of carbohydrates: cell - cell / cell - matrix / interactions between organisms

  • Glycoprotein
  • Stabilizes protein molecules
  • Affects biological function
  • Complex recognition
  • Lectins: (carb binding protein) promote interactions between cells and organisms

Don't forget about the age old question of describe two instances in which you would use the verbs ser and estar
Don't forget about the age old question of heschong thermal delight in architecture (epub|lit|mob)

Reducing Sugar - can alternate as a reducing agent because it has an aldehyde or ketone

  • Monosaccharides (glucose, fructose, galactose)
  • Some disaccharides (lactose, mattose)
  • Sucrose has glycosidic bond between anomeric carbons and cannot convert to open - chain form with aldehyde: stuck
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