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pcb4233

pcb4233

Description

School: Florida International University
Department: PCB
Course: immunology
Professor: Lanetty
Term: Spring 2017
Tags:
Cost: Free
Name: Immunology
Description: questions answered !
Uploaded: 02/07/2017
2 Pages 99 Views 4 Unlocks
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Test 1 study guide  1) How does the epithelia barrier in the skin, gut, and lung differ from a mechanical,  chemical and microbiological perspective? In the skin, you have sweat gland and sebaceous glands secreating oils and  lysozymes that break down  peptidoglycan. You also have  commensal microbes that produce  fatty acids and inhibit the growth of  other organisms ( competition of  resources).  On the lungs, you have cilia and mucous membranes to trap pathogens from the air. You also  have goblet cells that secrete more mucus. On the gut ( gastrointestinal and urogenital lining )  you have specialized cells producing acids that kill of most bacteria, specialized cells that secrete microcidal molecules  along with commensal microbes  2) What are the defensive chemical components present in the skin, the external epithelial  surface? The skin possesses sweat glands that release salty environment, inhibiting growth of bacteria, it  is slightly acidic, containing lysozymes and enzymes that break down peptidoglycan cell wall of  many bacteria. Other chemical components are dry surface RNases DNases, keratinocytes and  fatty acids.   3) What is a macrophage? Macrophages are phagocytic cells that migrate to all connective tissues of the body, they are the  first to fight pathogents entering the system.  4) How are the differences between macrophages and neutrophils? Macrophages Neutrophils  Induce inflammation Go to area of inflammation Response fast ( 0­4 hrs) Slow response ( 4 hrs­ 4 days Long lived Short lived ( within 5 days) Present pathogen fragments on surface Don’t present pathogen of their kills One big round nucleus Multilobed nucleus  Do phagocytosis Do phagocytosis 


3) What is a macrophage?




2) What are the defensive chemical components present in the skin, the external epithelial surface?




1) How does the epithelia barrier in the skin, gut, and lung differ from a mechanical, chemical and microbiological perspective?



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5) What are the events that take place once there is an infection and macrophages start  fighting with the microbial invaders? 1­ macrophage tries to kill invader, calls for help by secreting chemotactic factors to bring neutrophil and monocytes to the site of infection,  2­ neutrophils will travel though blood vessels and arrive site by extravasation 3­ monocytes will differentiate into macrophages and help destroy the pathogen 4­ neutrophils and macrophages destroy pathogen by phagocytic activity.  * if the pathogen is not killed the adaptive immune response is activated with naïve T and B cells become stimulated by antigen to proliferate and differentiate. The naïve cells are activate by  dentritic cells by pathogen ptrsentation activating the active effectors in t­helpter cells (CD4) and t­cytotoxic ( CD8) **
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