BIO SCI 97, Lecture Section A, MWF 11 am -11:50 am Midterm 1, 10/18/2013 RECORD ALL ANSWERS ON YOUR SCANTRON FORM HANDED OUT IN CLASS. YOU MUST USE THIS FORM. MAKE SURE THAT YOU BUBBLE IN YOUR STUDENT ID # AND THE VERSION OF THE EXAM (A, B, C) AS ANSWER #1 ON THE SCANTRON. Also write your name on the first page of the exam below. You must turn in your exam before you leave. You may tear off the last page of your exam and take it with you so that you know how you answered each question when the key is posted. AT THE END OF THE EXAM: (a) Be sure your name and ID are on the first page of the exam and your Scantron. (b) Make sure that your test version (A, B, C) is bubbled in on your Scantron as the answer to Question #1. (c) Bring your exam to the front, show your ID to the person collecting exams. (d) Leave through the lower doors, and remain silent until you leave the room. The exam key will be posted by the end of the week. Grading concerns: A reasoned description of why you feel your chosen answer is correct and/or why the posted answer is deficient should be E-MAILED to the head TA, Bekah Le Academic dishonesty (cheating) will not be tolerated in any form. The following are the EXAM RULES: 1) You must sit in your assigned seat with your ID on the desk and face up. 2) The ONLY items allowed on your desk in addition to the exam are: student ID (removed from any covers/cases) pencil, eraser, and NON-PROGRAMMABLE calculators (the calculator must not be able to store information; no other electronic devices are allowed). YOU MAY NOT BRING NOTES INTO THE EXAM IN ANY FORM. 3) You may not leave your seat (unless directed by a proctor) except to turn in your exam. 4) No questions will be answered by proctors or the instructors during the exam. 5) Your exam must be completed by you alone—keep your eyes on your own paper and no discussion with other students. Shield your own answers from other students. 6) NO baseball caps, phones, pagers, waterbottles, or bookbags are to be out during the exam. TURN RINGERS AND ALARMS OFF. These items must be UNDER your seat. 7) When the instructor declares the exam is over, there is to be NO WRITING. 8) You must sign this page to indicate that you understand these rules. IF YOU DO NOT SIGN BELOW, WE WILL NOT GRADE YOUR EXAM. FAILURE TO FOLLOW ANY OF THESE RULES MAY RESULT IN AN “F” ON THE EXAM OR IN THE COURSE FOR INSTANCES OF EXCEPTIONAL DISHONESTY. DO NOT TEST OUR RESOLUTION TO ADMINISTER A FAIR EXAM BY CHEATING. I UNDERSTAND THESE RULES AND AGREE TO FOLLOW THEM: _________________________________signature ___________________________ID# _________________________________printed name1 INSTRUCTIONS: There is only one correct answer for each question. There are 17 questions (16 really, “question” 1 is your exam version) and 5 pages of questions in the exam. 1. You have exam version A. Fill in “A” as the answer to question 1. 2. Homozygous wild-type female Drosophila were crossed to yellow-bodied male Drosophila. All of the resulting offspring were phenotypically wild type. Offspring of the F2 generation had the following phenotypes: Sex Phenotype Number male wild 96 male yellow 99 female wild 197 Based on this information: A. The yellow body gene is dominant B. The yellow body gene is dominant and maps to the Y chromosome C. The yellow body gene is recessive and maps to the Y chromosome D. The yellow body gene is recessive and maps to the X chromosome E. The yellow body gene is incompletely dominant 3. King George III of England was afflicted with a series of seemingly unrelated symptoms including abdominal pain, rapid pulse, convulsions, and insanity. It has been suggested that he suffered from porphyria, caused by a mutation in a gene involved in the synthesis of heme, that is an essential component of hemoglobin and myoglobin as well as important liver enzymes. The many different phenotypic effects seen are an example of: A. Epistasis B. Penetrance C. Co-dominance D. Pleiotropy E. Variable expressivity 4. Hemophilia is an X-linked recessive disorder that affects a gene for factor VIII, a protein essential for blood clotting. The dominant and recessive alleles for the factor VIII gene are H and h. Albinism is an autosomal recessive condition caused by mutations in tyrosinase, an enzyme in the melanin synthesis pathway. A and a represent the tyrosinase alleles. A healthy woman named Clara (II-2), whose father (I-1) has hemophilia and whose brother (II-1) has albinism, is married to a healthy man named Charles (II-3), whose parents are healthy. Charles's brother (II-5) has hemophilia, and his sister (II-4) has albinism. The pedigree is shown.2
What are the genotypes of Charles’ parents (I-3 and I-4) in this pedigree? A. I-3 is HYAA; I-4 is HhAa B. I-3 is HYAa;I-4 is HhAa C. I-3 is hYAa; I-4 is HhAa. D. I-3 is hYAa; I-4 is H_Aa E. I-3 is HYAa; I-4 is hhAa 5. The Chi-square test involves a statistical comparison between measured (observed) and predicted (expected) values. If one is testing a goodness of fit to a 9:3:3:1 ratio, how many degrees of freedom would be associated with the Chi-square analysis? A. 15 B. 8 C. 1 D. 3 E. 9 6. The ant, Myrmecia pilosula, is found in Australia and is named bulldog because of its aggressive behavior. It is particularly interesting because it carries all its genetic information in a single pair of chromosomes. In other words, 2n = 2. (Males are haploid and have just one chromosome.) The spindle is arranged horizontally from left to right. Which of the following figures would most likely represent a correct configuration of chromosomes of a female in mitotic metaphase?
How much DNA would be expected in a metaphase I cell of a female?
If one is testing a goodness of fit to a 9:3:3:1 ratio, how many degrees of freedom would be associated with the Chi-square analysis?
What are the genotypes of Charles’ parents (I-3 and I-4) in this pedigree?
We also discuss several other topics like housed the initial 4 mainframe computers connected to the ARPAnet and what were their incentives to contribute to the ARPAnet?
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3 7. Assume that a G1 somatic cell nucleus in a male Myrmecia pilosula contains 2 picograms of DNA. How much DNA would be expected in a metaphase I cell of a female? A) 16 picograms B) 32 picograms C) 8 picograms D) 4 picograms E) Not enough information is provided to answer the question. 8. Assume that in a series of experiments, plants with round seeds were crossed with plants with wrinkled seeds and the following offspring were obtained: 220 round and 180 wrinkled. What is the most probable genotype of each parent, assuming that round (W) is dominant to wrinkled? A. Ww x ww B. WW x Ww C. WW x wW D. Ww x Ww E. WW x ww 9. In peas, gray seed color is dominant to white. Assume that Mendel crossed plants with gray seeds with each other and the following progeny were produced: 320 gray and 80 white. Given the most probable genotype, what were the expected (theoretical) numbers of progeny (400 total) of each phenotypic class in this cross? A. 320, 80 B. 300, 100 C. 200, 200 D. 100, 200, 100 E. 400, 0 10. The compound 5'-azacytidine is used experimentally to treat patients with sickle cell anemia. 5'-azacytidine blocks the activity of DNA methyltransferases and is likely to:- A. Promote histone acetylation and decrease transcription of mutant globin B. Promote histone methylation, increasing globin transcription C. Decrease Cytosine methylation near fetal globin genes resulting in their expression D. Increase Cytosine methylation near fetal globin genes resulting in their activation E. Increase Guanine methylation near fetal globin genes resulting in their activation4 11. A mutagen has introduced a frame-shift mutation in a protein coding region by adding one nucleotide base. Which of the following changes in the gene might suppress or compensate for the effects of the mutation? A. deleting 2 additional bases B. adding 1 base C. deleting 1 base or adding 1 base D. deleting 1 base or adding 3 bases E. deleting 1 base or adding 2 bases 12. A polycistronic mRNA contains multiple: A. promoters B. exons C. Kozak sequences D. mRNAs E. polypeptide-producing sequences 13. It has been recently determined that the gene for Duchenne muscular dystrophy (DMD) is more than 2000 kb (kilobases) in length; however, the mRNA produced by this gene is only about 14 kb long. What is a likely cause of this discrepancy? A. The exons have been spliced out during mRNA processing. B. The DNA represents a double-stranded structure, whereas the RNA is single stranded. C. There are more amino acids coded for by the DNA than by the mRNA. D. The introns have been spliced out during mRNA processing. E. When the mRNA is produced, it is highly folded and therefore less long. 14. Which of the following statements about telomerase is incorrect? A. It is an enzyme that adds DNA to telomeres. B. It serves as the template for telomeres lengthening. C. It is activated in cancer cells. D. Its activity continually resets the cellular clock. E. It uses a DNA template to add telomere repeats5 15. Place in order the following steps involved in PCR: (1) newly synthesized strands act as templates (2) temperature lowered (3) heat separates strands of target DNA (4) complementary base pairing between primers and template (5) DNA nucleotide bases added; new strand synthesized A. 1 - 2 - 3 – 4 B. 3 - 5 - 4 - 2 - 3 – 1 C. 3 - 2 - 4 - 5 - 3 – 1 D. 2 - 3 - 4 - 5 - 2 – 1 E. 5 - 1 - 4 - 3 - 2 - 1 16. A short segment of an mRNA molecule is shown below. The polypeptide it codes for is also shown: 5'-AUGGUGCUGAAG : methionine-valine-leucine-lysine Assume that a mutation in the DNA occurs so that the fourth base (counting from the 5' end) of the messenger RNA now reads A rather than G. What sequence of amino acids will the mRNA now code for? (You do not need a copy of the genetic code to answer the question.) A) methionine-valine-leucine-lysine B) methionine-lysine-leucine-lysine C) methionine-leucine-leucine-lysine D) methionine-valine-methionine-lysine E) methionine-methionine-leucine-lysine 17. The horse (Equus caballus) has 32 pairs of chromosomes, whereas the donkey (Equus asinus) has 31 pairs of chromosomes. How many chromosomes would be expected in the somatic tissue of a mule? A. 32 B. 31 C. 62 D. 64 E. 636 a. ANSWER SHEET: This is the only page of the exam that you may take with you. Please tear it off the back and turn in the rest of your exam with your Scantron. Your Scantron will not be graded unless we also have your exam! 1. a 2. a b c d e 3. a b c d e 4. a b c d e 5. a b c d e 6. a b c d e 7. a b c d e 8. a b c d e 9. a b c d e 10. a b c d e 11. a b c d e 12. a b c d e 13. a b c d e 14. a b c d e 15. a b c d e 16. a b c d e 17. a b c d e 7