Description
Genetics Dr. Hom
What is genetics?
The branch of biology devoted to the Study of heredity and variation of traits (characteristics) that are observed as phenotypes (to show).
Basis of traits = genes
gene: fundamental unit of hereditary information; physically encoded by a
locus (region) of DNA
Heredity: DNA, sex, evolution
Vvariation: Statistics (populations)
Phenotypes: behavior
Central Dogma
the flow of genetic info in biological systems via polymers: DNA, RNA, and protein Don't forget about the age old question of 9781260304176
*start learning + memorizing
- All 20 common amino acids
structures + properties
- Nucleotides & nucleic acids
structures & properties
* know for exam 2
Sickle Cell Anemia
glutamate → val
ions change, dehydrates, microparticles
clogs arteries & veins
chromosome Il gene
*see white sheet for example reading assignment
* problem set #1 will be on top hat... due 9/1
Next class: cell cycle mitosis, meiosis
*problem sets begin today
Chromosomes
If you want to learn more check out What is a proposition which is always
true?
Centromere location
Designation
Middle
Between middle and end
Close to end
At the end
Metacentric
Submetacentric
Acrocentric
Telocentric
We also discuss several other topics like What processes are taking place right now that are chemical reactions?
Human genome DNA
* must be compacted 200,000 x
Don't forget about the age old question of What information is provided by managerial accounting goals?
Sugar: Ribose
We also discuss several other topics like What is the study of social collectives?
Nitrogenous Base
Pyrimidine
Uracil
Thymine
Cytosine
Purine
Adenine
Guanine
"Angels and god are pure and mighty"
⤷Big = two rings
Nucleotide Nomenclature
DNA Double Helix
A→T (2) hydrogen bonds
G→C grc has more hydrogen bonds (3)
* the more cag's in a DNA strand= more stable
* Know major and minor grooves & the size
magor (224)
minor (124)
one complete tum = 34 Å
Sickle cell Anemia
GAG → GTG
Healthy sickDon't forget about the age old question of What were the tools used during the Stone Age?
Glutamate valine
Dispersed in cytoplasm clumps in fibers
glycine (gly, G)
DNA Packing
Human Prions
Prp-C PrP-Sc
prion protein-cellular prion protein-scrapie
(they have altered quaternary structures)
*Next class: cell cycle
Alanine (Ala, A) has a methyl group for R (CH3)
pKa = 4.1
2 methyl groups
Carboxyl
Polar → acidic ↙repels
(negative charge)
if pH < pKa → have proton
if pH > pKa → no proton
"pick a proton off above this"
Lecture 3