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UCONN - PNB 2275 - Class Notes - Week 1

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UCONN - PNB 2275 - Class Notes - Week 1

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background image PNB 2265- Lecture 1- 1/19/18 Blood 1. Objectives a. Define the major composition of plasma and formed elements in the blood b. Interpret clinical tests (hematocrit, CBC) to predict blood  composition/pathology (e.g. anemias, polycythemia) c. Relate the structure of red blood cells to their function
d. Understand interaction between oxygen/carbon dioxide and 
how Hb faciliates gas transport e. Interpret alterations in the Hb-Oxygen dissociation curve f. Understand selected blood disorders (e.g. SCD)
g. Define the factors that regulate Erythropoiesis & Catabolism under 
normal/abnormal conditions h. Use blood testing principles to determine blood type, genetics. i. Identify major differences between the various formed elements
Draw the phases of hemostasis, and the intrinsic and extrinsic pathways.  2. Outline a. Blood composition/analysis
b. Red Blood Cells: Structure/Function
c. Erythropoiesis
d. Blood Typing
e. White Blood Cells: Classification
f. White Blood Cells: Production
g. Platelets: Function
h. Platelets: Production
i. Hemostasis
3. What is Blood? a. Blood is a connective tissue i. Blood is in capillaries, veins, ii. Liquid connective tissue iii. Composed of many different types of cells (fragments &  proteins)- liquid matrix- b. Composition: i.   Plasma (liquid) ii.   Cells- (white/red blood cells) iii.   Fragments (platelets) c.           Physical properties i.   Mostly water (plasma) ii. Neutral pH (7.4) d. Transport i. Nutrients, wastes, gases (O2 and CO2) e. Regulation i. pH (7.4 Buffer System) ii. Osmolarity iii. Temperature (38*C)- iv. Fluid Loss (Injury)- hemostasis- blood clotting f. Protection i. Component of immune system 4. Fractionated Blood (settlement of blood, or centrifugation)
background image a. Plasma (46-63%) i. Liquid Portion b. Formed Elements (37-54%) i. Buffy Coat Red Blood ii. Cells (RBC, WBC) iii. Cell Fragments (Platelets) – Buffy Coat c. Composition of Blood- i. Plasma (approx..50%) 1. Mostly water, some plasma proteins a. Plasma Proteins (yellowish color) 2. Hormones travel through this portion of the blood-  Regulatory proteins 3. Osmolarity is regulated by albumin protein- balances  solute concentrations within the interstitial fluid 4. Globulin Protein- makes antibodies in the immune  system 5. Fibrinogen- important for blood clotting ii. Formed Elements 1. Red Blood Cells (most cells)
2. White Blood Cells
3. Platelets 
5. Centrifugation of Blood- Hematocrit Testing a. Simple analysis i. Separates plasma from formed elements ii. Hematocrit- Volume Red Blood Cells Occupy in a blood  sample 1. Percentage of the volume
2. 50% Hematocrit (RBC takes up half of the sample)
b. *Top Hat Question i. In comparison to women, the hematocrit of men is typically: 1. Higher- testosterone regulates the process of blood  formation 2. Lower
3. The Same
6. Less simple analysis: Complete Blood Count (CBC) a. Takes a sample of blood and views it under a slide
b. Can provide detailed information about the composition of the blood
c. Sample CBC Result- detect hemostasis of the blood

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School: University of Connecticut
Department: Physiology
Course: Anatomy and Physiology 2
Professor: Chen and Dr. Tanner
Term: Fall 2016
Tags: anatomy and Physiology
Name: Lecture 1- Blood Note
Description: 1-19-2018 Notes on Blood
Uploaded: 01/19/2018
4 Pages 19 Views 15 Unlocks
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