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OSU - MICRBIO 4000 - Class Notes - Chapter 14

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Schools > Ohio State University > Microbiology > MICRBIO 4000 > OSU - MICRBIO 4000 - Class Notes - Chapter 14

OSU - MICRBIO 4000 - Class Notes - Chapter 14

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background image The Innate Immune Response Chapter 14
background image Immune System: Innate and Adaptive Immunity (Second-line defenses) -
background image A- BLOCK: First-line defenses are barriers blocking entry B- DETECT: If invaders breach, sensor systems detect C- DESTROY: Innate defenses work to destroy invaders The Innate Immune System
background image Outline: Key concepts A- First line defenses (BLOCK)  B- Cells of the immune systems and how they communicate 1- Leukocytes
2- Cytokines 
C- Pattern-recognition receptors; PRRs (DETECT) D- The complement system (DETECT and DESTROY) E- Phagocytosis (DESTROY) F- Inflammatory response (DESTROY)
G- Fever (DESTROY) 
background image A- First-Line Defenses First-line defenses block entry through inside and 
outside physical and chemical barriers:
1- Skin 2- Mucous Membranes 3- Antimicrobial Substances 4- Normal Microbiota/Flora: Not part of the immune system 
but provide considerable protection 
background image A1- Skin Skin Largest organ in our body (visible)  Difficult for microbes to penetrate; impermeable, inhospitable Epidermis: many layers of epithelial cells • Outermost are dead, filled with keratin – Repels water, dry environment
– Continually slough off along with
any attached microbes Moist skin  higher skin infections (ex: athlete’s foot) 
background image A2- Mucous Membranes Mucous Membranes Digestive, respiratory, genitourinary tracts Constantly bathed in secretions (e.g., mucus) that moistens 
tracts while trapping and washing off pathogens:  
• Mucociliary escalator of  respiratory tract propel 
microbes upwards to the
throat. Then? 
• Peristalsis of intestinal contents into the rectum
results in defecation.
background image A3- Antimicrobial Substances Antimicrobial Substances Salt accumulates from 
perspiration, protects skin
Stomach acid kills most bacteria  Lysozyme degrades 
peptidoglycan 
Peroxidase enzymes uses 
H
2 O 2 to form antimicrobial  oxidized compounds  Lactoferrin, a protein that binds 
iron; major element for microbes
AMPs (antimicrobial peptides) • Defensins form pores in  microbial membranes

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School: Ohio State University
Department: Microbiology
Course: Basic and Practical Microbiology
Professor: Tammy Madhura Pradhan
Term: Summer 2015
Tags: Microbiology and Innate Immunity
Name: Chapter 14
Description: Class notes of chapter slides with additional notes!
Uploaded: 03/31/2018
64 Pages 75 Views 60 Unlocks
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