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OSU - MICRBIO 4000 - Class Notes - Chapter 15

Created by: Laura Hagy Elite Notetaker

Schools > Ohio State University > Microbiology > MICRBIO 4000 > OSU - MICRBIO 4000 - Class Notes - Chapter 15

OSU - MICRBIO 4000 - Class Notes - Chapter 15

School: Ohio State University
Department: Microbiology
Course: Basic and Practical Microbiology
Professor: Tammy Madhura Pradhan
Term: Summer 2015
Tags: Microbiology and adaptive immunity
Name: Chapter 15
Description: Slide notes with additional notes about the adaptive immune system
Uploaded: 03/31/2018
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background image The Adaptive Immune Response Chapter 15  
background image Immune System: Innate and Adaptive Immunity Humoral
immunity
(B cells)
Cell-Mediated
immunity
(T cells) 
background image Outline (KEY Concepts)   A- Lymphocyte Development: B and T Cells  B- Anatomy of the Lymphatic System C- The Nature of Antigens
D- The Nature of Antibodies
1: Structure 
2: Function 
3: Classes 
E- Humoral Response (B Cells) A: T-independent Humoral Response
B: T-dependent Humoral Response
C: Primary and Secondary Immune Responses  F- Cell-Mediated Response (T cells)  A: T-Lymphocyte Characteristics B: Mechanism of Cell-Mediated Immunity
background image Terminology  BCR or Plasma 
B Cells 
Antigenic  determinant
background image A- Lymphocyte Development  Lymphocytes change as they develop/encounter antigen Immature lymphocytes lack fully developed 
antigen-specific receptors
Mature Naive lymphocytes have fully developed 
receptors; have not yet encountered appropriate 
antigen 
Activated lymphocytes have bound antigen and 
received confirmation, are able to proliferate to:
• Effector lymphocytes are descendants  of activated lymphocytes: 
Ex: plasma B cells, T
C cells, T H cells  • Memory lymphocytes are long-lived descendants of  activated lymphocytes; responsible for rapid secondary 
response if antigen encountered again
MATURATION ACTIVATION
background image B Lymphocytes or B cells  Responsible for Humoral Immune Response Form and mature in the bone marrow: Maturation involves negative selection of self-reactive B cells. Each B cell expresses several 
B-Cell Receptors (BCRs), all recognizing 
the same specific epitope
More than 100 million in our body  Travel to lymph, stored in lymph 
nodes as mature naïve B cells
background image B Lymphocytes or B cells  Naïve B cells are activated by recognizing and binding matching  extracellular antigen.  Extracellular antigens  Bacteria, toxin or  viruses circulating in bloodstream/fluids Activated B cells differentiate into: Plasma B cells: effectors B cells 
produce antibodies 
Memory B cells: long-lived specialized B cells that respond 
quickly to re-exposure in
secondary response 
background image T Lymphocytes or T cells  Responsible for Cell-Mediated Immune Response  Form in bone marrow and mature in thymus . Each T cell expresses T-Cell Receptors (TCRs), all recognize a  specific antigen only when presented by Major Histocompatibility  Complex (MHC)  Maturation in the thymus involves:  • Positive selection:  T cell eliminated if can not recognize self-MHC • Negative selection T cell eliminated if binds self-antigen on self-MHC 95%  of developing T cells  undergo apoptosis in thymus

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School: Ohio State University
Department: Microbiology
Course: Basic and Practical Microbiology
Professor: Tammy Madhura Pradhan
Term: Summer 2015
Tags: Microbiology and adaptive immunity
Name: Chapter 15
Description: Slide notes with additional notes about the adaptive immune system
Uploaded: 03/31/2018
68 Pages 85 Views 68 Unlocks
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  • 24/7 Homework help
  • Notes, Study Guides, Flashcards + More!
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