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WVU / Biochemistry / BIOC 410 / What is spliceosome?

What is spliceosome?

What is spliceosome?

Description

School: West Virginia University
Department: Biochemistry
Course: Introduction to Biochemistry
Professor: Kimberly barnes
Term: Fall 2018
Tags: ribonucleic, transcription, RNA, DNA polymerase, and spliceosome
Cost: 25
Name: Transcription
Description: Overview of notes discussed in lecture about transcription and the types of RNA.
Uploaded: 12/02/2018
1 Pages 33 Views 3 Unlocks
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Transcription


What is spliceosome?



Biochemistry Dr. Krauss

Highlight = Important Principle         Highlight = Key Term

Week 17 Transcription 

Gene Expression

­ Genes are not used until transcribed and expressed

­ Introns – portion of the gene not expressed into a protein

­ Exons – portion of the gene that is expressed into a protein 

­ RNA polymerase unwinds DNA and transcribes into RNA 

­ Contains 5 subunits

­ Transcription begins upstream 

­ A hairpin structure indicates termination of transcription 

­ See page 1048 to see RNA processing

­ Some introns splice themselves 


What is the difference between introns and exons?



­ See pages 1051­1058 for the processing and splicing methods. This material is hard to put into words, so  diagrams are used well

RNA Processing and Modification 

­ Bacterial mRNAs do not undergo any significant form of processing; the primary transcript that is  synthesized is itself the mature mRNA, and its translation usually begins before the transcription is  complete

­ Eukaryotic mRNA synthesis is fundamentally similar to bacterial mRNA transcription, but eukaryotic  transcription is processed far more

­ Eukaryotic mRNAs are processed as they are being synthesized, and that 5’ cap (7­ methyl guanosine) is added as soon as initiation begins If you want to learn more check out What is the study of matter?
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­ The termination of mRNA synthesis is due to polyadenylation 


What is a hairpin structure indicates?



­ Spliceosome – the protein­RNA complex involved in splicing GU­AG or AU­AC introns  ­ As previously state, transcription and translation each are processes difficult to explain and it is advised to view diagrams and videos on the subjects 

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