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UCONN - PNB 3260 - Class Notes - Week 8

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UCONN - PNB 3260 - Class Notes - Week 8

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background image Lecture 11:  Adult Neural Stem Cells and Neurogenesis 3/1  Overview:    CNS development    Embryonic niche    Adult NSC Niches  cytoarchitecture and signals  output and functions  injury/repair  CNS Cell types    Neurons    Glia  Oligodendrocytes: produce myelin  Astrocytes:  Ependymal cells    epithelial cells that line ventricles   Microglia - immune cells of CNS  Neurogenesis in the Embryo    Ventricular system    Neural Tube Induction  A)    Brain development    Earliest NSCs  Early embryo: up to E9 in mouse    Embryonic and Early Postnatal NSCs in Telencephalon    Adult NSC    Neural stem cells: cortical development  Detection of Neural Stem Cells    [H^3]-thymidine - incorporates into DNA during replication - S-phase  radio labeling  used before there were antibodies to define cell types    Thought initially that only astrocytes and microglial cells proliferated    1960s: dentate gyrus of hippocampus, neocortex and lateral wall of lateral ventricle  were found to have proliferative cells  1990s: Resurgence of adult neural stem cell research    BrdU (1982): bromodeocyuridine, synthetic thymidine analog, S-phase    Rapidly, inexpensively and safely detected by immunocytochemistry    Retroviral vectors: transduce a reporter transgene into genome of proliferating cells,  passed to all progeny and generations  Neurogenesis required for learning new songs  2dif regions in mouse brain:     Lateral Wall of the Lateral Ventricle    Hippocampal dentate gyrus  SVZ Niche    4 cell types  Ependyma    Multiciliated (motile)    postmitotic  Type A (neuroblasts)    highly migratory immature neurons  Type C (transit amplifying progenitors)    highly proliferative, immature phenotype  Type B (astrocytes)    slowly dividing cells    enshealth neuroblasts 

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School: University of Connecticut
Department: Physiology
Course: Stem Cell Biology
Professor: Conover
Term: Spring 2016
Name: Stem cell notes 3/1 and 3/3
Description: lecture notes
Uploaded: 03/04/2016
2 Pages 17 Views 13 Unlocks
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