Lecture Exam 2 Study Guide
Lecture Exam 2 Study Guide BSCI 201
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This 4 page Study Guide was uploaded by Brooke Sullivan on Monday March 14, 2016. The Study Guide belongs to BSCI 201 at University of Maryland taught by Dr. Meredith Bohannon in Spring 2016. Since its upload, it has received 343 views. For similar materials see Human Anatomy and Physiology in Biological Sciences at University of Maryland.
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Date Created: 03/14/16
Lecture Exam 2 Study Guide 3/17/16 10:47 PM Bones • Support, protection, movement, mineral and growth factor storage, blood cell formation, fat storage, and hormone production • Osteoblasts are bone building cells; they secrete unmineralized bone matrix called osteoid • Osteoclasts are bone breaking cells; they are huge, multinucleate cells that engage in bone resorption • Calcium Phosphate, Calcium Hydroxide, and Calcium Carbonate; First calcium phosphate and calcium hydroxide combine to create hydroxyapatite. This further combines with calcium carbonate and other ions to form mineral salt deposits that harden into bones in a process called calcification • Red bone marrow is found primarily in flat bones and is responsible for producing red blood cells, white blood cells, and platelets • Yellow bone marrow is located in the shaft of long bones and is responsible for producing fat, cartilage, and bone • Collagen fibers in the osteons run in different directions in adjacent rings which helps bones withstand stress and resist twisting • Collagen in the bone combines with minerals to form hydroxyapatite to form the structure, flexibility, and strength of bones • Osteocytes respond to mechanical stimuli and communicate the information to osteoblasts and osteoclasts so bone remodeling can occur • Hyaline Cartilage: joints, connecting ribs to sternum, larynx, nose tip • Fibrocartilage: pubic symphasis, vertebral discs, menisci of knees • Elastic Cartilage: external ears and epiglottis • Ossification is the process of laying down new bone material by osteoblasts while calcification is the mineralization and hardening of already existing bone tissue • Scenario 1: Embryonic Formation of Bony Skeleton - hyaline cartilage and fibrous membranes of fetal skeleton are replaced with bone tissue; comes from mesenchyme; endochondral and intramembranous ossification • Scenario 2: Postnatal Bone Growth – long bones grow by way of epiphyseal plate growth; bones increase in thickness because of appositional growth; this process stops after adolescence • Scenario 3: Bone Remodeling – a small percentage of bone tissue is being replaced at any time; new bone is stronger; process includes resorption and deposition • Scenario 4: Bone Repair – reactive, first reparative, second reparative, and remodeling stages to fix broken and fractured bones • Endochondral Ossification: Bone collar forms around diaphysis of cartilage model; central chondrites in diaphysis calcifies, then they go through apoptosis, resulting in cavities; periosteal bus invades cavities forming spongy bone; diaphysis elongates and the medullary cavity forms; epiphyses ossifies • Intramembranous Ossification: Mesenchymal cells cluster and become osteoblasts in ossification centers; osteoid is secretes, then calcifies; osteoid is laid down around blood vessels forming trabeculae; the lamellar bone replaces the woven bone • Resorption: the process of minerals from bones being returned to the blood • Resorption Process: osteoclasts dig grooves in bones called resoption bays; secrete enzymes and proteins that digest the matrix and increases acidity to break down the calcium salts and the organic parts of the matrix; digested fluids are trancysoed an released into the blood; osteoclasts apoptose • Deposition: the process of new bone being laid down • Bone Repair: Reactive stage – fracture hematoma; First reparative stage – fibrocartilaginous callus; Second reparative stage – bony callus; Remodeling stage – osteoclasts resorb last bits of fractured bone • Zones of Growing Epiphyseal Plate: Resting Zone – cartilage on the epiphyseal side of epiphyseal plate that is fairly inactive; Proliferation Zone – cartilage on diaphysis side of epiphyseal plate whose cells rapidly divides and move upward causing lengthening; Hypertrophic Zone – cartilage lacunae grow and erode causing the formation of interconnecting spaces; Calcification Zone – Surrounding cartilage matrix calcifies and chondrocytes die and deteriorate; Ossification Zone – the deterioration of chondrocytes creates long spicules of calcified cartilage at epiphysis-diaphysis junction that are then eroded and covered with new bone by osteoblasts. Afterwards, this new bone is replaced with spongy bone until the medullary cavity enlarges and the spicules are eroded 3/17/16 10:47 PM 3/17/16 10:47 PM
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