Exam 1 notes
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This 3 page Study Guide was uploaded by Sreya Notetaker on Tuesday October 6, 2015. The Study Guide belongs to BIOL 3010 at University of Toledo taught by John Gray in Summer 2015. Since its upload, it has received 78 views. For similar materials see Molecular Genetics in Biology at University of Toledo.
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Date Created: 10/06/15
Molecular Genetics Notes Lecture 1 0 Central dogma of genetic study DNA gt RNA gt Protein E 3 W t i g 1quot i 3 DNA J Transc p flon ERMA 1 Translation complex 0 What is a gene 0 Functional unit of DNA coding for RNA and protein 0 Mutation and Natural Selection 0 Different living species share the same molecular mechanisms ex Kit gene in developmental and maintenance of pigment 0 Differentiation in same organism even though every cell has the same set of genes 0 Blood cells vs nerve cells 0 Manipulation and application of genetic info 0 Animal and plant breeding 0 Genetic engineering 0 Genomics and proteomics 0 Bioinformatics 0 Genetic basis of diversity Lecture 2 Mendel s law of genetic inheritance O Gregor Mendel deduced that genetic characters are controlled by factors that exist in pairs 0 When two unlike factors for a single trait coeXist one factor is dominant to the other Principle of Segregation during the formation of gametes the paired factors segregate randomly so that each gamete receives one or the other factor With equal likelihood Principle of Independent Assortment during the formation of gametes segregating pairs of unit factors assort independently of each other Gentic Terms and Techniques O O Monohybrid cross mating between two different alleles at one genetic locus of interest Homozygous cross an individual has two same alleles whether dominant or recessive Heterozygous cross having one of two different alleles Punnett square diagram that is used to predict an outcome of a particular cross or breeding experiment Test cross introduced by Mendel breeding of a phenotypically dominant individual with a phenotypically recessive individual Alleles an alternative form of a gene Dihybrid cross cross between two pure lines that differ in two observed traits Analysis of a Dihybrid Cross yezllawimund X gleamwrinklad ll P1 EI39DEB P1 crass yellow wrinkled K green muznd F1 x F1 Product law of asitajjgr iift j il lii Probabilities 0 When two independent events occur simultaneously the combined probability of the two outcomes is equal to the product of their individual probability occurrence can use when generating a phenotypic ratio using the forkedline method example F1 yalluw mund X gallium round F2 ll ufl aprlng all nfl aprlng Gamhlnad prahabilitiaa Smnam an a yellow ramId 3m are raund 3M are yellow and W are wrinkled 4 Emma an a yellnw wrinkled Hilliard 3H E Qil EEl ruuml Elf431m rmund m are green and 1 1 are wrinkle 1LMH1LM1HJE green wrinkleEl Analysis of a Trihybrid cross Gana ratian af F tri hyhrid hgnutypas Cnmhing yprngpnpr mn 3M 6 3M 3MJC3M ABC am A m E 1 m E a amnmmm ABE isms4 EE m b 3m ch amumuam me 9m Abe m r minimum Abe am ABE a E 3M Crt1 4nmnama c Emil 356 1 a V m a magnum ass a 355 V V 34 3 wumnam am a abc m b m a 1MMM 11f4 ab 1m ab Genetic Pedegree Analysis a Autosomal Recessive Trait l Either H or H must be 1 2 3 4 heterozygous Recessive traits typically ll 1 i skip generations 1 2 3 4 S 6 7 Ij V Reces sive autosoma l traits lll I I appear equally in both sexes 1 2 3 4 5 6 2010 Pearson Education lnc
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