drug study guide
drug study guide NROSCI 0081
Popular in DRUGS AND BEHAVIOR
Popular in Neuroscience
This 2 page Study Guide was uploaded by Anna Perry on Wednesday October 21, 2015. The Study Guide belongs to NROSCI 0081 at University of Pittsburgh taught by Fanselow,Erika in Fall 2015. Since its upload, it has received 59 views. For similar materials see DRUGS AND BEHAVIOR in Neuroscience at University of Pittsburgh.
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Date Created: 10/21/15
Drug Class Drug Pharmacokinetics Pharmacodynamics Effects Stimulants Cocaine Snorted powder or inhaled Binds to dopamine End up with more mimics crack faster reuptake transporter dopamine in sympathetic Rapidly broken down by synapse autonomic PNS liver and blood enzymes Can also block Action potentials Somewhat fat soluble voltage gated Na can t be channels transmitted Can be anesthetic MethAmphetami Broken down slowly by Indirect agonist of Enhances release ne liver monoamines Blocks or action of mimics Longer half life than coke reuptake of them neurotransmitter sympathetic Taken as pills usually and increases their without agonist autonomic PNS release activity at receptor Nicotine Tar inhaled by vaporizing Agonist for nicotinic Mimics increased heat at end of cigarette acetylcholine acetylcholine activity of Crosses bloodbrain barrier receptors sympathetic and Metabolized by liver Let s Na into Excites dopamine parasympathetic Excreted by kidneys neuron neurons autonomic PNS Affects mesolimbic Increases activity pathway of dopamine neurons Caffeine Beveragespills Blocks GABAA Blocks inhibition Absorbed from digestive receptors system and converted to Blocks receptors for Prevents metabolites xanthines by adenosine adenosine from liver sedation of body Excreted in urine Legal Alcohol Oral administration Antagonist at NMDA Reduces glutamate Uptake occurs rapidly receptors release lowering through GI tract passes excitation in the through liver into brain brain Crosses many membranes Stimulates GABA Increases inhibition Enzymel makes release and in post synaptic something toxic enzyme2 increases function of cell removes it receptors Excreted through urine Increases dopamine Related to its lungs and sweat activity addictivity Increases release of Feels good natural opioids Illegal for Cannabis Smoked Endocannabinoids Receptors on pre no reason Lipid soluble can go are released from synaptic neurons through membranes post synaptic Stored in fat cells neuron Can be eaten also Cannabinoid Decrease activity receptors activate of inhibitory neurons which release GABA and glutamate Serotonin LSD Dissolved in liquid or put Enhance effects of One type of like on tabs serotonin serotonin receptor hallucinoge Lipid soluble can cause ns hallucinations Psilocybin Psilocybin is converted to psilocin which can enter brain Peyote Similar to amphetamine mescaline BeHadonna Jimsonweed Atropine has effects Block muscarinic Increases heart alkaloids mimics shutdown outside the brain and can acetylcholine rate and affects of be lethal receptor memory parasympathetic Scopolamine enters brain PNS easily and causes psychoactive effects Dissociative PCP Pills powder or rocks Antagonis lndirectl Contributes to the anesthetic Ketamine t for y cause fact that users can hallucinoge NMDA release become dependent ns glutamate of on them receptors dopami ne DXM Drank from bottle Antagonist for NMDA Prevents excitatory glutamate receptors transmission MDMA Ecstasy Usually taken as pills Binds to serotonin Blocks reuptake mimics Well absorbed from GI transporter promotes release sympathetic autonomic PNS tract
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