Chapter 7 Study Guide
Chapter 7 Study Guide PCB 3233
University of Central Florida
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This 2 page Study Guide was uploaded by Aleece Betts on Thursday October 29, 2015. The Study Guide belongs to PCB 3233 at University of Central Florida taught by Dr. Gregory Weigel in Summer 2015. Since its upload, it has received 148 views. For similar materials see Immunology in Biomedical Sciences at University of Central Florida.
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Date Created: 10/29/15
Chapter 7 Study Guide Initial thymus is called thymic anlage T cells mature in the thymus B chains have VD J segments rearranged x chains have VJ segments RAG genes are used in the rearrangement Pre TCR consists of a B chain with pTa b CD3 complex c C chain a IL7 binds to 1L7 receptor during one step in maturation telling the cell what to do next b Notch 1 present at all maturation steps helps differentiate cells Cause of DiGeorge s syndrome chromosome 22 deleted thymus never develops Double negative thymocytes have no CD4 8 receptors found in the thymus RAG l and 2 are used to rearrange T cells as well as B cells Positive selection takes place first in the thymus cortex negative selection comes next and occurs in the cortico medullary junction T cells have long life spans compared to B cells Twelve presenting MHC molecules 120000 possible peptides By5 chains are rearranged at approximately the same time The 5 chain is deleted when the x chain genes are rearranged this happens during the last stage of the maturation of double negative thymocytes XB receptors are more common four attempts at rearrangement CD48 are expressed after B chain rearrangement it is considered a single positive cell after positive selection Positive selection gets rid of cells that don t bind to MHC peptides occurs in thymic cortex mediated by cortical epithelial cells T cells that fail positive selection die by apoptosis Approximately 2 of cells survive positive and negative selection The MHC molecule that a TCR initially encounters is the type of MHC molecule it will forever recognize The type of MHC molecule encountered also determines which CD4 8 receptor Will be present Dendritic cells and macrophages preside over negative selection Cells that don t meet an antigen in the thymus are able to leave but Will become anergic Ligand receptor interactions are probably the method of positive and negative selection Regulatory cells are CD4 cells With CD25 and FoxP3 T cells pair With antigenMHC molecules in secondary lymphoid organs AIDS patients have more CD8 cells than CD4 cells
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