New User Special Price Expires in

Let's log you in.

Sign in with Facebook


Don't have a StudySoup account? Create one here!


Create a StudySoup account

Be part of our community, it's free to join!

Sign up with Facebook


Create your account
By creating an account you agree to StudySoup's terms and conditions and privacy policy

Already have a StudySoup account? Login here

Fundamentals of Human Genetics

by: Mrs. Willis Mante

Fundamentals of Human Genetics MCDB 1041

Mrs. Willis Mante

GPA 3.6

Jennifer Knight

Almost Ready


These notes were just uploaded, and will be ready to view shortly.

Purchase these notes here, or revisit this page.

Either way, we'll remind you when they're ready :)

Preview These Notes for FREE

Get a free preview of these Notes, just enter your email below.

Unlock Preview
Unlock Preview

Preview these materials now for free

Why put in your email? Get access to more of this material and other relevant free materials for your school

View Preview

About this Document

Jennifer Knight
Study Guide
50 ?




Popular in Course

Popular in Molecular, Cellular And Developmental Biology

This 3 page Study Guide was uploaded by Mrs. Willis Mante on Thursday October 29, 2015. The Study Guide belongs to MCDB 1041 at University of Colorado at Boulder taught by Jennifer Knight in Fall. Since its upload, it has received 54 views. For similar materials see /class/231840/mcdb-1041-university-of-colorado-at-boulder in Molecular, Cellular And Developmental Biology at University of Colorado at Boulder.

Popular in Molecular, Cellular And Developmental Biology


Reviews for Fundamentals of Human Genetics


Report this Material


What is Karma?


Karma is the currency of StudySoup.

You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!

Date Created: 10/29/15
MCDB 1041 Exam 3 Gene expression 1 2 Explain gene expression How do cells end up different even though they have the same DNA Know what a promoter is and what a transcription factor is Be able to describe how for some genes multiple proteins can be made by alternative splicing DNA technology recombinant DNA using DNA markers 1 P39er 0 PCR as a replication technique understand the basic idea of how it works what a primer is and how they are used Describe how restriction enzymes work and be able to describe how you would use restriction enzymes to cut DNA and visualize it Also be able to use this technique to be able to distinguish whether someone has a mutation in a particular gene Be able to describe how a gene is cloned into a plasmid and why you would do it Describe what gel electrophoresis is and how it is used to work with DNA Explain DNA ngerprinting techniques know what an STR is and how it can be used to determine identity Be able to analyze an STR readout gel Explain the relationship between variation in DNA and the use of STRs Be able to determine the mode of inheritance from a pedigree combined with a gel of STR data 7 De ne the term transgenic and be able to describe how transgenic plants and animals are made 8 Why might you make a transgenic animal or plant 9 In a transgenic animal how do you target the production of the recombinant protein and why Cloning 1 What are the techniques for cloning an entire organism Why might it be useful 2 3 How would you make a transgenic clone and why would you What are the features that are different between a clone and the organism it was cloned from Stem Cells and Gene Therapy 1 Elk59 0 What is therapeutic cloning vs reproductive cloning Howe are embryonic stem cells generated and what can they be used for What are some other kinds of stem cells and how are they different from embryonic stem cells What is gene therapy and how can it be used How do you get good copies of DNA into humans who need it gene therapy Why are viruses good for this feature Be able to describe at least one way that gene therapy can be done MCDB 1041 Exam 1 Fall 2008 Format Review Questions and Terms An excellent way to review is to go back over clicker questions homework and activitiesthose are the kinds of questions I ll be asking In general I am less interested in memorization and more interested in application That said in order to understand genetics there are certain things you just have to knowi de nitions of terms chromosomal numbers rules of inheritance how to calculate probabilities etc I won t ask for de nitions and I won t ask you to regurgitate other facts I will require that you understand the concepts and definitions so that you can apply them to answering questions See the end of the sheet for a list of terms you should know The format of the exam will be as follows Multiple choice about 12 the test Some short answer questions like descriptions of how a process works Longer questions including such things as interpreting pedigrees and working genetic problems crosses linkage pedigrees etc Review Sheet 1 Be able to analyze phenotypic data and deduce patterns of from family histories a Draw a pedigree based on information in a story problem b Distinguish between dominant recessive autosomal Xlinked and mitochondrial modes of inheritance c Calculate the probability that an individual in a pedigree has a particular genotype d Be able to figure out which people should be carriers if they are not marked 2 Describe the mechanisms by which an organism s genome is passed on to the next generation a Define somatic and germline cells and list similarities and differences between them b Explain why germline mutations can be passed onto the next generation whereas somatic mutations cannot c Describe using diagrams the sequence of events involving DNA in meiosis from chromosome duplication through chromosome segregationiin particular be able to describe or draw how meiosis I and II are different d Explain how independent assortment of alleles during meiosis can lead to new combinations of alleles of unlinked genes e Be able to describe the cell cycle interphaseGlS G2 and mitosis and what happens in each phase eg when does replication of chromosomes happen f Know human chromosome structure and number in humans 22 nonidentical pairs of autosomes either XX or XY 46 g Be able to describe Mitosisihow it works what the result is why cells do it h Be able to distinguish between a sister chromosome and a homologous pair of chromosomes and know how chromosomes line up at the metaphase plate before the cell divides into two i Know the function of membranes the nucleus the mitochondria and why they are important 3 Use genetic crosses to calculate the probability of inheritance of particular alleles and to predict phenotypes of offspring Mendelian Genetics a Predict progeny g u 1 pi f 1 39 given the g u t p of the parental gametes b Identify an allele s mode of inheritance from progeny phenotypes c Know the difference between the chromosomal content of a gamete and a regular body cell be able to draw a Punnet Square and use it for visualizing possible offspring from a cross between two individuals d Know what you do when there are multiple possible outcomes in a Punnett square that match the outcome you re looking for e Be able to calculate the chance frequency of producing a gamete or an offspring with a certain genotype Know how to do this for genes on different chromosomes as well as genes that are linked f Understand Mendel39s Laws the law of segregation and the law of independent assortment and how they relate to meiosis g Know how Mendel s laws apply to working genetic problems IV Exceptions to Mendel39s laws a Describe the phenomenon of linkage and its consequences on assortment of alleles during meiosis 1 Understand why linkage has an effect on segregation of chromosomes into gametes 2 Diagram the process of recombination crossing over during meiosis and explain how it can lead to new combinations of linked alleles 3 Understand how to figure out parental and recombinant gametes 4 Explain how a specific combination of linked alleles can appear more frequently 5 Determine probability of inheriting particular allele combinations of linked genes given map distances between the genes b Know the terms A 39 and 39 r and how they are different cUnderstand how multiple alleles for a single can change the number of possible phenotypes in a population d Compare the outcome of a cross with simple dominantrecessive alleles to the outcomes of a cross with lethal alleles or codominant alleles e Know the different blood type alleles and how they make the different blood types A AB 0 B 1 1 MUST KNOW TERMS Allele Genotype Phenotype Gene Plasma membrane Protein Homozygous Heterozygous Dominant Recessive Sister chromosomes Replicated chromosome Homologous chromosomes Gamete Carriers


Buy Material

Are you sure you want to buy this material for

50 Karma

Buy Material

BOOM! Enjoy Your Free Notes!

We've added these Notes to your profile, click here to view them now.


You're already Subscribed!

Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'

Why people love StudySoup

Jim McGreen Ohio University

"Knowing I can count on the Elite Notetaker in my class allows me to focus on what the professor is saying instead of just scribbling notes the whole time and falling behind."

Allison Fischer University of Alabama

"I signed up to be an Elite Notetaker with 2 of my sorority sisters this semester. We just posted our notes weekly and were each making over $600 per month. I LOVE StudySoup!"

Bentley McCaw University of Florida

"I was shooting for a perfect 4.0 GPA this semester. Having StudySoup as a study aid was critical to helping me achieve my goal...and I nailed it!"

Parker Thompson 500 Startups

"It's a great way for students to improve their educational experience and it seemed like a product that everybody wants, so all the people participating are winning."

Become an Elite Notetaker and start selling your notes online!

Refund Policy


All subscriptions to StudySoup are paid in full at the time of subscribing. To change your credit card information or to cancel your subscription, go to "Edit Settings". All credit card information will be available there. If you should decide to cancel your subscription, it will continue to be valid until the next payment period, as all payments for the current period were made in advance. For special circumstances, please email


StudySoup has more than 1 million course-specific study resources to help students study smarter. If you’re having trouble finding what you’re looking for, our customer support team can help you find what you need! Feel free to contact them here:

Recurring Subscriptions: If you have canceled your recurring subscription on the day of renewal and have not downloaded any documents, you may request a refund by submitting an email to

Satisfaction Guarantee: If you’re not satisfied with your subscription, you can contact us for further help. Contact must be made within 3 business days of your subscription purchase and your refund request will be subject for review.

Please Note: Refunds can never be provided more than 30 days after the initial purchase date regardless of your activity on the site.