Survey of Biochemistry
Survey of Biochemistry CHEM 3511
Popular in Course
Popular in Chemistry
This 0 page Study Guide was uploaded by Tierra Ernser on Monday November 2, 2015. The Study Guide belongs to CHEM 3511 at Georgia Institute of Technology - Main Campus taught by Loren Williams in Fall. Since its upload, it has received 150 views. For similar materials see /class/234317/chem-3511-georgia-institute-of-technology-main-campus in Chemistry at Georgia Institute of Technology - Main Campus.
Reviews for Survey of Biochemistry
Report this Material
What is Karma?
Karma is the currency of StudySoup.
You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!
Date Created: 11/02/15
Final Exam Study Guide Chapter 16 Citric Acid Cycle Matching Or Fill In Choose the correct answer from the list Not all the answers will be used l omit red questions Another name for the citric acid cycle is the A oxaloacetate 2 is one of the products of the citric acid cycle B malate Synthase that is used by plants C malate D malonate 3 is the rst compound that is oxidized in the E Krebs eyele citric acid cycle F aconltase G succmylCoA synthetase 4 is an enzyme that catalyzes a substratelevel H X39ketogllnarate phosphorylation I carbon d1ox1de J malate dehydrogenase 5 The citric acid cycle intermediate is found at K isocitrate the beginning and at the end of the citric acid cycle L 511001113 dehydrogenase 6 The only membranebound enzyme of the citric acid cycle is 7 The name of this citric acid cycle intermediate is derived from apple 8 The enzyme contains an iron sulfur cluster 9 The compound is a competitive inhibitor of succinate dehydrogenase 10 The enzyme is part of the glyoxylate cycle Fill In Questions 11 is an intermediate between citrate and isocitrate in the citric acid cycle 12 is the metabolic intermediate that condenses with oxaloacetate to form citrate 13 During the oxidation of isocitrate the intermediate that is decarboxylated to form x ketoglutarate is 4 In eukaryotes the enzymes of the citric acid cycle are located in the Chapter 16 Citric Acid Cycle 15 One FAD one GTP and in the citric acid cycle NADH are produced when one acetyl group is oxidized Multiple Choice Questions 16 The two main purposes of the citric acid cycle are 17 18 19 A synthesis of citrate and gluconeogenesis B degradation of acetylCoA to produce energy and to supply precursors for anabolism C degradation of pyruvate to produce energy and to supply precursors for anabolism D degradation of glucose to produce energy and to supply precursors for anabolism E degradation of pyruvate to produce energy and to synthesize oxaloacetate for gluconeogenesis The isomerization of citrate to isocitrate A is the only unnecessary step of the citric acid cycle B protects cells from the toxic effects of arsenite ion C converts a tertiary alcohol which cannot easily be oxidized to a secondary alcohol that can be oxidized D is a major regulatory step for the citric acid cycle E is an oxidation reaction Which of the following causes pyruvate dehydrogenase kinase to catalyze the phosphorylation and inactivation of E1 in the pyruvate dehydrogenase complex A elevated concentrations of NADH and ATP B elevated concentrations of NAD and ADP C Ca2 D insulin E elevated concentrations of acetylCoA Which of the following structures corresponds to glyoxylate A H ozcicicoz B H CHycio C H OZCCH27C7C02 D H H oicicio E Introduction to Metabolism Study Guide Matching Or Fill In Choose the correct answer from the list Not all the answers will be used l Prokaryotes that are able to synthesize all of their cellular components from simple molecules such as C02 H20 NH3 and H28 are called A anabOhc B adenylate k1nase 2 Organisms that require oxygen are called C 80v D t b l39 3 Biomolecules are synthesized from simpler 13 13121 10 components in pathways F obligate aerobes G l h h t 47 13Bisphosphoglycerate is a type of 7 H Ztelimjisgs a e I NADPH 5 The enzyme catalyzes the react1on PPi a 2 J pyrophosphatase PI K autotrophs L oxidation 6 The enzyme catalyzes the transfer of a M AGOV phosphoryl group from ATP to AMP 7 A loss of electrons from a substance is known as 8 The oxidized form of NADH is 9 The standard reduction potential at the biochemical standard state is symbolized as 10 The study of the complete set of proteins synthesized in the cell is called Fill In Questions 11 The rate of ow of metabolites through a metabolic pathway is referred to as 12 is the process by which nutrients are degraded in order to salvage their components andor to generate energy 13 The reactants intermediates and products of metabolism are all referred to as Chapter 13 Introduction to Metabolism 14 A bond whose hydrolysis proceeds with large negative value of AG 39 is often referred to as a bond 15 ATP contains one phosphoester bond and two bonds 16 The process by which ATP is formed by the direct transfer of a phosphoryl group to ADP from a highenergy compound is referred to as phosphorylation 19 The reduction of NAD involves ion transfer 20 Two widely used electron carriers in metabolism are NAD and Multiple Choice Questions 21 Organisms that are poisoned by oxygen are A obligate aerobes B facultative anaerobes C autotrophs D chemolithotrophs E obligate anaerobes 22 Which of the following is at a higher level of oxidation than CH3CHO A CH3CH20H B CH3CH3 C CH2CH2 D CH3COzH E none of the above 23 Consider the following metabolic reaction SuccinylCoA A a A 39 r oA 39 AGO3971251dmol What is the Keq for this reaction at 25 C A 166 B 0602 C 100 D 422 x102 E 0321 24 Consider the following metabolic reaction SuccinylCoA Acetoacetate a AcetoacetylCoA Succinate AG 7125 kJmol The AG for the hydrolysis of SuccinylCoA is 7339 kJmol What is the AG for the hydrolysis of AcetoacetylCoA AcetoacetylCoA a Acetoacetate CoA A 7352 ldmol B 7327 kJmol C 327 kJmol D 352 kJmole E none of the above Chapter 13 Introduction to Metabolism 25 26 27 28 29 Consider the following metabolic reaction SuccinylCoA Acetoacetate a AcetoacetylCoA Succinate AG 125 kJmol This reaction is A favorable under standard conditions B not favorable under standard conditions C always exergonic and can never proceed in the opposite direction D spontaneous as written when succinate and acetoacetylCoA are high E None of the above The Keq is 0503 at 25 C for the following reaction What is the AG 39 for this reaction DGlucose6phosphate a DFructose6phosphate A 71700 Jmol B 72870 Jmol C 143 Jmol D 170 kJmol E none of the above Consider the following metabolic reaction 2Phosphoglycerate a 3Phosphoglycerate AG 440 kJmol What can be said about this reaction when the concentration of 2phosphoglycerate is 0490 mM and the concentration of 3phosphoglycerate is 290 mM at 25 C A This reaction is endergonic under these conditions B This reaction is exergonic under these conditions C This reaction is at equilibrium under these conditions D This reaction is not favorable under standard conditions E 40 1d of work can be done by this reaction under these conditions Consider the following metabolic reaction 3Phosphoglycerate a 2Phosphoglycerate AG 440 ldmol What is the AG for this reaction when the concentration of 2phosphoglycerate is 0290 mM and the concentration of 3phosphoglycerate is 290 mM at 37 C A 103 kJmol B 154 kJmol C 130 kJmol D 593 kJmol E 440 kJmol Which of the numbered arrows in the 1 NH figure to the right points toward a high 5 4 2 energy phosphoanhydride bond 039 H10 039 H1 ltN N A 1 39oirLoirLoirLoiCH2 N J B 2 a as as o N C 3 3 2 Chapter 13 Introduction to Metabolism 30 D4 E5 Given that the standard reduction potential of oxaloacetate is 70166 V and the standard reduction potential of NAD is 70315 V What is the A 39 for the oxidation of malate by NADl Malate NAD a Oxaloacetate NADH H A 7481 V B 481 V C 70149 V D 0149 V E 00523 V Short Answer Questions Write your answer in the space provided or on a separate sheet ofpaper 31 32 33 34 35 36 37 38 39 40 41 42 What reaction rates describe the ux of an intermediate in a metabolic pathway List four ways by which cells control or regulate the ux through metabolic pathways What are two factors that contribute to the large negative standard free energy change for the reaction ATP a ADP P What is meant by the term substratelevel phosphorylation What are isozymes Brie y explain how a reaction that has a positive value of AG can be exergonic and hence proceed as written from left to right What is the importance of ATP s intermediate phosphoryl grouptransfer potential to energy metabolism in a cell Why are the vitamins niacin and ribo avin necessary for metabolism What is the relationship between the electromotive force and the AG of a reaction Brie y describe how isotopic labeling techniques have revolutionized the study of metabolism What is the advantage of pyrophosphate cleavage of ATP What is the role of AcetylCoA in catabolism Answer AcetylCoA is the common product of the degradation of proteins carbohydrates and fats AcetylCoA then enters the citric acid cycle for further catabolism Section 1 Level of Dif culty moderate
Are you sure you want to buy this material for
You're already Subscribed!
Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'