Last exam of the semester
Last exam of the semester BIOL 3303 - 001
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BIOL 3303 - 001
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This 0 page Study Guide was uploaded by Danielle Banks on Thursday November 19, 2015. The Study Guide belongs to BIOL 3303 - 001 at University of Texas at Arlington taught by Perry Fuchs in Fall 2015. Since its upload, it has received 159 views. For similar materials see DRUGS AND BEHAVIOR in Biology at University of Texas at Arlington.
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Date Created: 11/19/15
111015 Lecture Notes over Marijuana Chapter 7 Marijuana is a plant 60 things can be isolated from the marijuana plant The Acute Effects of marijuana Absorption is rapid sec peak effects around 10 mins behavioral effects ast around 2 hours THC marijuana is marijuana THC absorbed into fatty tissue therefore excretion is very slow Metabolite halflife around 50 hours Physiological effects increased heart rate increase decrease or no change in blood pressure dilation of vessels in eyes Extremely safe drug lethal dose around 20000 40000 X s the effective dose 100Ibs of weed for 15mins Many people who go to the emergency room will have THC in the system Reaction times are not changed however tracking behavior is impaired THC acts at a receptor which is normally activated by anandomide CHRONIC EFFECTS 1 Tolerance effects increase as dose increases 2 Dependence Some signs of physical dependence but only at extremely high doses Psychological dependence can occur Low toxicity thc like receptors are not found in brain stem 0 Acute effects of marijuana on the heart rate ike Heart disease high blood pressure or arteriosclerosis can worsen the condition 111215 Withdrawals and Dependence Feeling irritability stomach pain anxiety and loss of appetite Now chronic users have higher ingested levels of THC show negative physical symptoms 0 Cardiovascular effects THC increase heart rate but no conclusive evidence of adverse effects in the cardiovascular functioning in young healthy people Toxicity No human deaths have been reported from THC overdose Panic reaction Chronic ung exposure reproductive effect Suppressed immune function Medical Use Brand name for capsule containing THC is Marinol 1 Glaucoma THC decrease intraocuar pressure 2 Asthma Oral administration causes bronchodiator 3 Nausea during chemotherapy 4 Marijuana joint is equivalent to that of up to ve tobacco cigarettes in this regard 5 Marijuana smoking does not increase the risk of developing emphysema a chronic lung disease associated with tobacco 6 No de nitive evidence of increase in lung cancer rates among marijuana smokers 7 Marijuana is a gate way drug 8 Gateway hypothesis the idea that the abuse of a speci c drug will inherently lead to the abuse of other more harmful drugs 9 Amotivational syndrome a state of listlessness and personality involving a generalized apathy and indifference to long range plans 101968 William McGlothlin a psychologist and Louis West a psychiatrist proposed that chronic marijuana smoking amount young people was responsible for a generalized sense of apathy in their lives Alcohol Social Beverage Socia Drug Chapter 8 1 Fermentation glucose transferred to ethyl alcohol and carbon dioxide 2 Brewing process of fermenting grains 3 4 Mash fermented barely malt Distillation process to increase alcohol content following liquefaction and combination with yeasts History Of Alcohol Mead was the original alcoholic beverage back about 8000BC Egyptians established the rst of cial brewery 3700BC Aqua vitae means the water of life Dutch new alcoholic Gin 111715 Lecture Notes 1 Absorption Most absorbed in small intestine Carbonation increases rate by which the stomach empties its content 2 Metabolism Requires no digestion and its absorbed unchanged into bloodstream Alcohogtalcoho dehydrogenase gt acetaldehyde gt acetaldehyde dehydrogenase gt Acetic Acid 3 Measuring alcohol in the blood Blood alcohol concentration Dull and digni ed at alcohol level 003 005 dashing and debonair 01 become dangerous and devilish 02 to be dizzy and disturbing 035 he is dead drunk 06 chances are he is dead Effects of Alcohol on the CNS Alcohol is a CNS depressants possibly acting at the GABA receptor ED for surgical anesthesia is very close to LD Behavioral effects related to depression of higher cortical function followed by depression of brainstem areas Acute Physiological effects Toxic reactions LD50ED50 ratio is relatively small about 6 therefore not very safe drug Heat Loss Diuretic effects Cardiovascular effects Hangover One drink for females two drinks for males a day P P PWF Acute Behavioral Effects 1 Blackouts 2 Impairment of driving skills 3 Aggression and violence 95 of campus sexual assault is use by alcohol either the man women or both 4 Sex and sexual desire one in seven young people admits to having unsafe sex after drinking alcohol Chronic Alcohol Abuse and Alcoholism 5 related basic issues 1 Problems associated with a preoccupation with drinking binge drinking females 4 or more drinks for males it is 5 or more drinks Symptomatic drinking 2 Emotional problems 3 Vocational social family problems 4 Physical problems 5 Hiding the problem Biological Effects Of Chronic Alcohol Use 1 Tolerance and withdrawal Evidence of tolerance Physical Dependence seen as alcohol withdrawal syndrome or a series of signs caed delirium tremens DT s impatient 2 Liver Disease Fatty liver Alcoholic hepatitis liver in ammation Alcoholic cirrhosis scarring 3 Cardiovascular Problems 4 Wenickle Korsakoff Syndrome 1st stage associated with confusion disorientation eye movements hard in body coordination Sever stage associated with sever memory impairment Involves thiamine de ciency 5 Fetal Alcohol Syndrome Alcohol easily passes the placental barrier No determination of a quot safequot Genetics of Alcoholism Questions To what extent is alcoholism related to genetic Answer 1 Adoption studies slightly higher incidence in adopted children of alcoholic biological parents 3 Twin Studies Concordance rate is lt 1 4 Therefore both nature and nurture contribute alcoholism Treatment Biologically based Used of disu ram Associated drinking with negative consequence Naltrexone Treatment Block properties of the drug Alcoholics Anonymous Developed in the 195039s 3 Rational Recovery 4 Treatment effective Signi cant relapse rate factors such as a job stability of family relationships minimal psychopathology minimal abuse of others drugs contribute effective treatment 75 relapse Lecture 111915 The Biomedical Model Primary mode of therapy for most mentally ill patients revolve around drug therapy Symptoms gt Diagnosis gt Cause gt Cure Abnormal thoughts and feeling a result of abnormal biochemical process Therefore return biochemical processes towards a more normal state Classi cation of Mental Disorders Different ways of de ning mental disorders based on Deviation from normal Cultural criterion Personal distress Lega de nition Treatment of Mental Disorders before 1950 1917 introduction of malaria therapy for general paresis 192039s use of barbiturates and other depressants 1933 Insulin treatment for schizophrenia 193039s use of eectroconvusive shock therapy PWN Use of frontal lobotomy Drilling a hole in your head walter freeman developed more of a disconnection Antipsychotics 195039s development of group of drugs called phenothiazine What is Schizophrenia Negative symptoms lack of emotion don39t speak as much Two types of schizophrenia type 1 and type 2 Etiology of schizophrenia is unknown but there is a clear genetic in uence and environmental in uence Antipsychotics act via D2 receptor new generation also blocks serotonin receptor drugs are not addicting and relatively safe Main side effects is tardive dyskinesia lip smacking trouble feeding themselves New drug have less of this effect Drugs used to treat mood disorders Depression Depressed mood most of the day diminished interest signi cant changes in body weight Insomnia psychomotor agitation fatigue felling of worthless suicide attempt or committing B The symptoms cause clinically signi cant distress or impairment C Not due to a drug or medical condition What Causes Depression Imbalance of chemical NTs heredity personality How these factors interact in not known Drugs used to treat major depression 1 MAO Inhibitors Phenelzine Nardil Tranycypromine Parnate
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