Test 5 PCB 3233
University of Central Florida
Popular in Immunology
Popular in Biomedical Sciences
This 3 page Study Guide was uploaded by Aleece Betts on Thursday November 19, 2015. The Study Guide belongs to PCB 3233 at University of Central Florida taught by Dr. Gregory Weigel in Summer 2015. Since its upload, it has received 58 views. For similar materials see Immunology in Biomedical Sciences at University of Central Florida.
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Date Created: 11/19/15
Exam 5 Study Guide 1. Cells that can become plasma cells: a. Centrocytes that have gone through both somatic hypermutation and isotype switching b. Active B cells c. Memory B cells 2. B cell coreceptor: a. Complement receptor 2 b. CD 81, aka TAPA1 c. CD 19 3. CR 1 produces C3d, which then binds to CR 2 4. TI means “thymusindependent”, whereas TD means “thymus dependent”. TI antigens are capable of being controlled by the Bcells of a person lacking a thymus. 5. A Bcell’s CD40 marker pairs with a Tcell’s CD40 ligand, which alerts TF NFκB to produce ICAM1. The Tcell then reorganizes its structure to send out IL4 cytokines onto the B cell. 6. a. FDCs cause B cells colonies to differentiate and increase in the dark zone; the final product is a centrocyte, which moves to the light zone to find an antigen on the FDCs. b. Dark zone: B cells, T FHells, FDCs, centroblasts. Light zone: centrocytes, FH Cells, FDCs c. Centroblasts become mature centrocytes in the dark zone, and centrocytes then either pair with an antigen or suffer apoptosis in the light zone 7. Antibodies do not destroy the antigen directly. 8. a. The B cell and antigen form a pair along the membrane surface. b. Cognate interactions occur between B and T cells that match with the same antigen. c. The primary focus is in the medullary cords; IgM is the main isotype. d. Medullary cords are the region right outside the T cell zone. e. IL4 induces isotype switching f. These cause B lymphoblasts to become plasma cells g. A germinal center is basically an enlarged primary follicle where B and T cells mature. Exam 5 Study Guide 9. IL10 creates plasma cells, IL4 creates memory cells 10. Hyper IgM syndrome occurs when patients do not have a CD 40 ligand. This usually occurs in men, and is a result of being incapable of switching isotypes. 11. Fc regions alert phagocytic cells of antigens. There are no receptors on phagocytes for IgM Fc regions, but this region is able to initiate the complement system. 12. Brambell receptors transport antibodies across tissues. It looks like MHC class 1, and two receptors are used in transportation. 13. PolyIg receptors create an enhanced binding interaction with antigen. They look like a pentamer and are used by IgM. 14. Transcytosis is when vesicles carry molecules across tissue walls. 15. IgG is transported across the placenta by Brambell receptors. 16. Dimeric IgA is in the breast milk and protects the baby’s intestines. 17. Antivenom is a passive transfer of immunity. 18. Passive immunity occurs when a patient is given antibodies to a pathogen, instead of a neutralized antigen. Examples include: cases of snake bites and tetanus. 19. Immune complexes consist of antigen and antibody. Phagocytic cells, such as macrophages, destroy the complex. 20. Dimeric IgA is produced in the lamina propia and protects mucosal surfaces. 21. Fc receptors carry antibodies where blood and lymph can’t go. They also act as an in between for the immune complexes and phagocytic cells. 22. ADCC stands for “antibodydependent cell mediated cytotoxicity. 23. C3 starts the alternative pathway and C1 starts the classical pathway. 24. C1 is activated after binding to receptors on IgG and IgM. C1 is used in both the alternative pathway and the classical pathway. 25. The alternative pathway helps the classical pathway by producing huge amounts of C3a/b. 26. CR1 binds to C3b, and CR2 binds to C3d. 27. Antibody levels would be higher with stronger affinity. 28. Primary immune response is the first interaction with a new pathogen, while secondary immune response is a repeated encounter. Primary immune response consists of B cells and effector T cells, while the secondary immune response also includes memory cells. 29. Mucosal tissue has the highest concentration of lymphocytes. IgA has the highest concentration and is found in mucosal surfaces. Exam 5 Study Guide 30. M cells use transcytosis to bring pathogens into the peyer’s patch. They do not secrete anything. They take pathogen from the lumen area to the basolateral surface. 31. Peyer’s patches are somewhat circular and lie just under the intestinal epithelium. 32. Phagocytic leukocytes in the gut cannot secrete cytokines 33. Lymphocytes activated in the gut can recirculate where MAdCAM1 is present. 34. Basophils, neutrophils, and eusinophils are granular leukocytes, whereas lymphocytes and monocytes are agranular leukocytes. 35. The site of infection is where memory T cells are activated. 36. Peyer’s patches include B&T cells, dendritic cells, and M cells. 37. Mesenteric lymph nodes, peyer’s patches, adenoids/lingual tonsils and palantine tonsils make up the secondary lymphoid tissues of the gastrointestinal tract.
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