Test 5 study guide
Test 5 study guide PCB 3233
University of Central Florida
Popular in Immunology
Popular in Biomedical Sciences
This 4 page Study Guide was uploaded by Aleece Betts on Thursday November 19, 2015. The Study Guide belongs to PCB 3233 at University of Central Florida taught by Dr. Gregory Weigel in Summer 2015. Since its upload, it has received 88 views. For similar materials see Immunology in Biomedical Sciences at University of Central Florida.
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Date Created: 11/19/15
Exam 5 Study Guide 1 Cells that can become plasma cells a Centrocytes that have gone through both somatic hypermutation and isotype switching b Active B cells c Memory B cells 2 B cell coreceptor a Complement receptor 2 b CD 81 aka TAPAl c CD 19 3 CR 1 produces C3d which then binds to CR 2 4 TI means thymusindependent whereas TD means thymus dependent TI antigens are capable of being controlled by the Bcells of a person lacking a thymus 5 A Bcell s CD40 marker pairs with a Tcell s CD40 ligand which alerts TF NFKB to produce ICAMl The Tcell then reorganizes its structure to send out IL 4 cytokines onto the B cell a FDCs cause B cells colonies to differentiate and increase in the dark zone the final product is a centrocyte which moves to the light zone to find an antigen on the FDCs b Dark zone B cells TFH Cells FDCs centroblasts Light zone centrocytes TFH Cells FDCs c Centroblasts become mature centrocytes in the dark zone and centrocytes then either pair with an antigen or suffer apoptosis in the light zone 7 8 10 11 12 13 14 15 16 Exam 5 Study Guide Antibodies do not destroy the antigen directly a The B cell and antigen form a pair along the membrane surface b Cognate interactions occur between B and T cells that match with the same antigen c The primary focus is in the medullary cords IgM is the main isotype d Medullary cords are the region right outside the T cell zone e IL 4 induces isotype switching f These cause B lymphoblasts to become plasma cells g A germinal center is basically an enlarged primary follicle where B and T cells mature IL lO creates plasma cells IL 4 creates memory cells Hyper IgM syndrome occurs when patients do not have a CD 40 ligand This usually occurs in men and is a result of being incapable of switching isotypes Fc regions alert phagocytic cells of antigens There are no receptors on phagocytes for IgM Fc regions but this region is able to initiate the complement system Brambell receptors transport antibodies across tissues It looks like MHC class 1 and two receptors are used in transportation PolyIg receptors create an enhanced binding interaction with antigen They look like a pentamer and are used by IgM Transcytosis is when vesicles carry molecules across tissue walls IgG is transported across the placenta by Brambell receptors Dimeric IgA is in the breast milk and protects the baby s intestines 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Exam 5 Study Guide Antivenom is a passive transfer of immunity Passive immunity occurs when a patient is given antibodies to a pathogen instead of a neutralized antigen Examples include cases of snake bites and tetanus Immune complexes consist of antigen and antibody Phagocytic cells such as macrophages destroy the complex Dimeric IgA is produced in the lamina propia and protects mucosal surfaces Fc receptors carry antibodies where blood and lymph can t go They also act as an in between for the immune complexes and phagocytic cells ADCC stands for antibodydependent cell mediated cytotoxicity C3 starts the alternative pathway and C1 starts the classical pathway C1 is activated after binding to receptors on IgG and IgM C1 is used in both the alternative pathway and the classical pathway The alternative pathway helps the classical pathway by producing huge amounts of C3ab CR1 binds to C3b and CR2 binds to C3d Antibody levels would be higher with stronger affinity Primary immune response is the first interaction with a new pathogen while secondary immune response is a repeated encounter Primary immune response consists of B cells and effector T cells while the secondary immune response also includes memory cells Mucosal tissue has the highest concentration of lymphocytes IgA has the highest concentration and is found in mucosal surfaces M cells use transcytosis to bring pathogens into the peyer s patch They do not secrete anything They take pathogen from the lumen area to the basolateral surface Peyer s patches are somewhat circular and lie just under the intestinal epithelium 32 33 34 35 36 37 Exam 5 Study Guide Phagocytic leukocytes in the gut cannot secrete cytokines Lymphocytes activated in the gut can recirculate Where MAdCAMl is present Basophils neutrophils and eusinophils are granular leukocytes Whereas lymphocytes and monocytes are agranular leukocytes The site of infection is Where memory T cells are activated Peyer s patches include BampT cells dendritic cells and M cells Mesenteric lymph nodes peyer s patches adenoidslingual tonsils and palantine tonsils make up the secondary lymphoid tissues of the gastrointestinal tract
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