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Ommega 7® Sea Buckthorn OlCaapsuee for Woomeen’sHeealth FIN-95410E-mail: email@example.com Finland www.aromtech.com Introduction to Women’s Health Care Toward Modern, Natural Health Care Beautiful skin and healthy mucous membranes are in important role in women’s life – they are the signs of health and well-being. However, skin and mucous membranes are constantly under the challenges of different factors such as stress,, ,ging, side effects of medical treatments and environmental contamination. The perception of women’s health and personal care has in recent years developed in more holistic direction, as opposed to conventional cosmetic or syndrome-related medicinal approach. A healthy diet and dietary supplementation by essential nutrients and bioactive compponents are becoming g indispensable constituents of modern healthcare strategies. Lipids are essential structural components of the skin and mucous membranes. Polyunsaturated fatty acids play an important role in multiple aspects of the whole body physiology. Antioxidants are of extreme importance in order to protect polyunsaturated fatty acids and other cellular components of the skin from oxidative stress of the environment, ageing and stress. Targeted oral supplementation of these bioactive components, designed to correct an imbalance in modern diet enhances the health and beauty of the skin and mucous membranes. UniqueeSeea Brckthorn Sea Buckthorn (Hippophaë Rhamnoides) syrb bearing hardy plant naturally distributed in Europe and Asia and cultivated in these regions as well as in North America. Through a long history of adaptation to the harsh climate, Sea Buckthorn has developed a unique composition that meets perfectly the needs of human hthl alth. The pearl-shaped berry is known as ”nutrient bomb” and is claimed to contain more than two hundred bioactive compounds, among which natural vitamins, antioxidants, essential fatty acids, and plant sterols have been well investigated(Yang, 2001; Yang and Kallio, 2002). Aromtech Ltd Tel: +358 207 789 020 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com Introduction to Women’s Health Care One special feature of Sea Buckthorn is that the berry contains oil both in seed and in the soft parts. The seed oil is rich in essential fatty acids (often called Omega fatty acids), linoleic and alfa-linolenic acids, and the pulp oil is the richest source of palmitoleic acid, rarely found in the plant kingdom. Both seed oil and pulp oil contain high levels of natural vitamin E (tocopherols and tocot)ilnols) ad pllant sterolls. From Ancient Traditions to Modern Health Care Since ancient times Sea Buckthorn berry has been used as a valuable source of nutrient by local people, and its appllcaton in Asian traditonaalmeedicines dates bback to more than one thousand years ago. In more than 300 ancient prescriptions Sea Buckthorn is used to improve blood circulation, reduce inflammation, regenerate skin and mucous membranes and treat gynaecology disorders. During the past few decades scientists have carried out extensive research in Seea Bucckthorn. Ths haas resulted improved understanding of the health effects and chemical composition of the berry. Due to the rich content of essential fatty acids, antioxidants and vitamins, Sea Buckthorn Oils offer support to women’s health – not only to improve perimenopausal symptoms but also to maintain the health and wellbeenggof wommennthrougghout lfetime. Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 Finland10 Kiviranta www.aromtech.commtech.com ® Omega 7 Sea Buckthorn Oil Capsule for Women’s Health CONTENT 1. Introduction to Women’s Health Care 2. Omeega 7 SSea Buckthorn Capsule orr Women’s Health ® 3. Unique Composition of Omega 7 Sea Buckthorn Capsule 4. Omega 7 and skin ® • Efficacy of Omega 7 on atopic skin • Omega 7 and skin ageing ® 4. Omega 7 and mucous membranes ® • Efficacy of Omega 7 on Sjögren’s syndrome 5. Omega 7 and hearth health 6. Omeega 7 hhas antinflammmatoryandd anti-analgesic properties 7. Omega 7 ® enhances microcirculation 8. Omega 7 ® improves gastric ulcer 9. References 10. Technical data 111. Customer testimonials Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com Omega 7 Sea Buckthorn Oil Capsule for Women’s Health Omega 7 Sea Buckthorn Oil Capsule The health of skin and mucous membranes plays an important role in the well-being and quality of life of women. Omega 7 ® supports Women’s Health by nourishing, regenerating and strengthening the skin and the mucous membranes. Ancient knowledge about Sea Buckthorn For more than a thousand years sea buckthorn has been used in Asian traditional medicines for healing wounds in skin and treating infections and inflammation in mucous membranes. It is often used to improve the blood cicuuatton and cellreneewallofgyneecologicaltssuees. Standardised product based on modern technology Sea buckthorn berry is known to contain hundreds of natural bioactive compounds. Omega 7 is a vegetable- based capsule product of SBA24 Sea Buckthorn Oil, manufactured by y supercritical CO2 extraction technolgy. Omega 7 ® is a standardised concentrate of the most important beneficial components of sea buckthorn. Clinically substantiated health effects The beneficial effects of Omega 7 ® on the skin and mucous membranes have been substantiated by producctspeecficcllncalland expeermeentallstudies. Omega 7 ® and skin •improvesatopiceczema • has anti-inflammatory and analgesic effects • slows down the ageing processes of skin Omega 7 and mucous membranes • regenerates uro-genital mucous membranes • improves dry mouth conditions • protects gastric mucosa, cures gastric ulcer In addition, Omega 7 ® increases blood HDL-cholesterol level. Aromtech Ltd Tel: +358 207 789 020 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com Unique composition of Omega 7 ® Omega 7 Sea Buckthorn Oil Capsule Sea buckthorn oil concentrates the most important bioactive compounds of the berries. Both the composition and the quality of sea buckthorn oils of different sources vary greatly because of the huge differences in berries anprocessing technologgies. Omega 7 is a standardised sea buckthorn oil based on a long research experience, a well established raw material supplying network as well as strong expertise in processing technology. Omega7 contains fatty acids of all biologically important famiiles,omeega-3, 6,7 annd 9.Esppecialy, ts the rcheest source of natural vitamins and antioxidants such as carotenoids, tocopherols and tocotrienols as well as plant sterols. The uniqueness of Omega 7 is the natural combination of a wide range of physiologically important compounds in one product, which ensures synergistic health effects. Thee ssuperorr andd cconstant qqually oof OOmeega77® sis achieved by a close monitoring of raw material supplying chain and a strict control of oil extraction process according to the ISO9001 quality system. Manufactured by supercritical CO2 extraction technology, Omega 7 is a solvent-free, 100% natural product. (Yang and Kallio, 2002) Aromtech Ltd Tel: +358 207 789 020 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com Omega 7 and SKIN Omega 7® promotes wound healing and tissue regeneration Sea buckthorn oil has some tissue regenerative effects and it has long been used for promoting wound healing and fortreating skin scalds and burns. Sea buckthorn oil also speeds up the regeneration and renewal of normal skin. ® Omega 7 improves dermatitis and eczema In both oral and topical applications, sea buckthorn oil is especially effective in treating different types of dermaattis suchh ass atopic eeczemaa aand iraddatton- induced dermatitis. Omega 7 reduces skin inflammation Inflammation is commonly found in different skin disorders and sensitive skin types. Omega 7 ® is a wonderful solution for inflammatoy skins. Omega 7 protects skin cells from oxidative attacks Skin is exposed to a wide range of oxidative stresses such as UV, air pollutes and ageing. Omega7 ® contains multiple antioxidants, which synergistically protect skin cells from the oxidative attack. (Yang, 2001; Yang and Kallio, 2003) Omega 7 slows down the ageing processes of skin ® Omega 7 significantly slows down the ageing processes of mature skin by hydrating the skin, increasing the softness and elasticity of the skin as well as decreasing the amount of deep wrinkles. (A long-term human study, 2007) Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com Efficacy of Omega 7 on ® Atopic skin Study design The characteristic signs of atopic dermatitis include dry, scaly, itchy skin with with eczematous inflammation and typical distribution of lesions. In a placebo-controlled,, parallel, randomized, double-blind study 49 atopic dermatitis patients took Sea Buckthorn Seed and Pulp Oil and paraffin (as a placebo) capsules, ten capsules (5.0 g oil) per day y, each pproduct for 4 months. Sea Buckthorn oils were manufactured by y supercritical CO e2traction processing method. The changes in plasma lipids were controlled and the condition of the dermatitis was followed based on the SCORAD system. Results During the follow-up dermatitis improved. The mean SCORAD values representing symptom severiity wereis filnificantly or remark kblbly llower affter 1-month h andd 44-month h administration by Sea Buckthorn Oils.The positive correlations were found between symptom improvement and the increase in alfa-linolenic acid in plasma phopholipids and neutral lipids. patients with atopic dermatitis 49 randomly divided seed oil group pulp oil group placebo group 12 16 21 Figure 1.Study design 5 g oil/day for 45 g oil/day for 4 months paraffin oil seed oil pulp oil capsules capsules capsules A B C before treatment after one-month after four-months Symptom Symptom Symptom Plasma FA Plasma FA Plasma FA Figure 2. Study control Skin FA Skin FA Roughness Roughness Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com ® Efficacy of Omega 7 on Atopic skin 45 40 Figure 3. Change in SCORAD values in the A beginning, after 1-month treatment and 35 seed oil 30 pulp oil after 4-month treatment. AD values B C paebo R25 SCO 15 A B C time points Atopic eczema symptom improvement positively correlates with increase in proportion of essential fatty acid in plasma 18:3n-3: PL 18:3n-3: NL Rs = 0.84 p = 0.001 Rs = 0.68 p = 0.02 30 30 y = 70.46x - 0.93 y = 12.85x - 0.15 20 20 10 10 SI - AB0 SI - AB0 Δ Δ -0.2 0 0.2 0.4 -1 0 1 2 -100 10 -20 -20 Δ 18:3n-3, B - A Δ 18:3n-3, B - A Figure44. and A..Af, beftorettBenftt; B, after one-h treattmentPLL, hosphollid; NL, neuttrall lipids. (Yang et al., J.Nutr.Biochem. 10:622-630, 1999) Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com Omega 7 and Skin ageing ® Omeegga 7 SSea Buuckthorn OiilCappsules for Natural Skin Care The ageing process considerably alters both the structure and the mechanical properties of skin. Aged skin is less extensible and less elastic than younger skin. Fine lines and wrinkles are a characteristic signs of aged and especially photo-aged skin. Wrinkle formation is due to the decrease of elasticity, photo-aging and free radical attack on skin. ® Omega 7 Sea Buckthorn Oil Capsule is an excellent source of essential nutrients foregglating moisture and sensitiy of skin. Study Design The aim of the study was to evaluate the efficacy of Omega 7 ® Sea Buckthorn Oil capsules to reduce the signs of ageing through measurements of skin hydration, elasticity and skin roughness. In a clinical study 30 healthy women (average age 61 years) took 2 capsules twice a day for three moonths. Instrumental measurements of the selected parameters were performed on the forehead at the beginning, after 1 month and after 3 months of the treatment. 60 Skin hydration – Measurements 55 Corneometer C CM 825 ( (Courage & & 50 Khazaka) was used to investigate skin hydration. The physical principle of the 45 instrument is based on its c.u. capacitance. The measured value is 40 directly proportional to the amount of 35 water contained in stratum corneum annd trepresenns the hydratonn evellof 30 cutaneous surface, expressed by corneometric units (c.u.), which are 25 the instrument arbitrary units. The T0 device can measure values ranging time T1 between 0 and 150 corneometric units. T3 T0 = mean value at the beginning of the treatment T1 = mean value after one month of the treatment T3 = mean value after three months of the treatment Skin hydration - Results A highly significant increase (p=0.0001) in the skin hydration was recorded during and after the treatment: increase in moisturisation after 1 month: 33.6% after3 moonths:4886%% Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com Omega 7 and Skin ageing Skin elasticity – Measurements The Cutometer SEM 575 (Courage & Khazaka) was used to measure the vertical deformation of the skin. The data obtained by the device were expressed in millimetres. The skin surface was sucked into the o pegning of a measuring probe, in which a constant level of 0,55 depression was created (350 mbar) for an 0,53 established time (1 second). The air depression 0,51 was then annulled and the released skin could return to its original position. 0,49 0,47 Three measurement cycles (1 cycle: R20,45 suction/release) were performed on the same 0,43 point. 0,41 0,39 An optical system measured the variations in electrical capacitance. These were proportional 0,37 to the rise of the skin surface which had been measured (expressed in mm). 0,35 T0 The skin rises were shown on Cartesian axes, ttiime T1 whhere tthe def foitation of thes kkiin(expressed iin T3 mm) is a function of time (expressed in seconds). Therefore the three suction/release cycles were represented as three successive curves, which provide the measurement of the deformation T0 = mean value at the beginning of the treatment parameters relating to the elastic features of the skin. T1 = mean value after one month of the treatment T3 = mean value after three months of the treatment The overall elasticity was announced as a ratio between the total deformation recovery at the end of the stress-off period (Ua) and the maximal deformation of the skin (Uf) : Ua / Uf =overall elasticity referred to as parameter R2 Skin elasticity - Results A highly statistically significant increase (p=0.0001) in the skin overall elasticity was recorded during and after the treatment. increase in skin overall elasticity: after 1 month: 16.3% after 3 months: 25.8% ® Omega 7 and Skin ageing 114 Skin roughness – Measurements 112 Image analysis (Monaderm) was used in measuring the wrinkles. Skin replicas were taken 110 and analysed by a designed image processing Rz108 software (Quantilines, Monaderm) which allows a global data analysis of some relief parameters, 106 according to the method described by Corcuff. 104 Each silicon replica of the cutaneous surface 102 was lightened by a light source with a defined incident angle (35°) with the purpose of 100 generating shadows: the higher the furrows, the T0 wider the shadows. time T1 The software allowed the measurement of the T3 following parameters; mean roughness value annd maaxmuum rroughnesss vauee deeep wrinkess). T0 = mean value at the beginning of the treatmenThe anti-wrinkle efficacy could be proved by a T1 = mean value after one month of the treatment T3 = mean value after three months of the treatmentrease of R a or Rz values (Rz value=max roughness value) Skin rouughnnesss -Reesuulss A moderate decrease in the skin maximum roughness was recorded during and after the treatment. decrease in deep wrinkles: after 1 month: 3.6 % after 3 months: 9.2 % Summary Omega 7 Sea Buckthorn Oil Capsules significantly slow down the ageing processes of mature skin by hydrating the skin, increasing the softness and elasticity of the skin as well as decreasing the amountt ofdeep wril kles.Bi ing a hh source of vabablean tiiodanttsOmega 7 7 SSeahBtkckthornOiill Capsules also protect skin from the photo-ageing and from other free radical attacks caused by stress, smoking and environmental pollution. Omega 7 ® and MUCOUS MEMBRANES Health of mucous membranes Mucous membranes cover the digestive, respiratory, and urogenital tracts and the inner surface of eyes. They are important channels for interactions between the body and the environment and are the major routes for pathogens, toxins and allergens to enter the body. Thus mucous membranes play an important role in the health andd generall wellbei ing f thew h hl lebddy. MMucous membranes are often attacked by diseases, stress, ageing and side effects of medication. ® Omega 7 nourishes and regenerates mucous membranes Omega 7 ® not only promotes mucous membrane regeneration but alsoprovides the nutrients essential for the proper functioning and renewal of mucous membranes. ® Omega 7 maintains health of stomach and intestine Omega 7 ® prevents and heals chemically- and stress- induced damage in the mucosa of the inner side of the stomach and intestine. ® Omega 7 restores health of genital tract Both topical and oral use of Omega 7 ® improve the symptoms of chronic virginal inflammation and dryness. ® Omega 7 relieves dry mouth symptoms Uncomfortable and dry mouth often troubles people suffernggfrom ddiseases, meedicaton, sress and aggengg. In clinical studies, Omega 7 ® improves dry mouth symptoms. Omega 7 ® also reduces inflammation and improves the general condition of mouth mucosa. 2002; Yang, B. Effect of oral supplementation with capsules ofet al, supercritical CO2 extracted sea buckthorn (Hippophaë rhamnoides) oil on mucous membranes of patients of Sjögren's syndrome. 97th AOCCS AnlnualMiteting&Expo2006, li ri30-May 3, SttLiuis, Missouri, USA) Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com Efficacy of Omega 7 ® on Sjögren’s syndrome Stdy gisign Omega 7® is a vegetable-based capsule product of SBA 24 Sea Buckthorn Oil manufactured by supercritical CO extraction technology (Figure 2). 2 In a placebo-controlled, double-blind, cross-ove® study, twenty four female Sjögren`s syndrome patients took Omega 7 SBA 24))and ractonated oconut oiiFCO, asa placebo)) capsules, six capsules (3.0 g oil) per day, each product for three months. The conditions of the mucosa of the eyes, mouth and genital tract and the skin were evaluated using a visual analogue scale (VAS) before and after each of the supplementation periods. 25 20 SBA 24 Figure 1. Scores describing improvement after the treatments measured by 15 Placebo VAS. Scores 1= an improved case, 0 = an unchanged case, -1 = a worsened case 10 Results scores 5 More patients had the cond®tion of the genital mucosa 0 improved by the use of Omega 7 SBA 24 than FCO (placebo) (P <0.01, Figure 3). In addition, the use of SBA 24 led toabetter itching burnipain secretion dryness overall improvement in the symptoms of Sjögren’s syndrome -5 (Figure 4), suggesting beneficial effects of Omega 7 (SBA 24) Sea Buckthorn Oil Capsule on the overall condition of the mucous membranes. *The study has been published at the 97th Annual Meeting & Expo of the American Oil Chemists’ Society (April-May, 2006, St. Louis, USA). % improved after using SBA 24 from baseline %Improved after using placebo from baseline 120 %worsened after using SBA 24 from baseline 100 %worsened after using placebo from baseline rov80 cases p 60 40 20 0 ng g ss ss ss n a percentage ofrnm pain yne yness yn e tpi itch bu secretionr dr dr dyn fatiguji le fingnrczem eye uth ose pa ski mo n Figure 4. Improvement in symptoms of Sjögren`s syndrome after the first three months of treatments measured by VAS Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com ® Omega 7 and HEART HEALTH Omega 7 Sea Buckthorn Oil Capsule The effect of sea buckthorn oil on cardiovascular health has been widely studied by scientific investigations. The results strongly support that the sea buckthorn oil improves the blood lipid profile and reduces the risk factors of the cardiovascular disease. Omega 7 increases the level of good cholesterol Good cholesterol HDL speeds up of the clearance of cholesterol and maintains the lipid balance. Eating ® Omega 7 increases blood HDL levels. Omega 7 reduces the harmful effects of bad cholesterol Oxidation of LDL is the key point for the detrimental effects of the bad cholesterol. Through the synergy of multiple natural antioxidants, Omega 7 ® inhibits LDL oxidation. Omega 7 inhibits blood clotting In clinical studies Omega 7 significantly reduces platelet aggregation. This prevents the blood from clotting and keeps the blood vessel open for normal circulation. Anti-inflammatory property of Omega 7® is important Inflammation is actively involved in the process of cardiovascular diseases. Inhibiting inflammation in blood vessels, Omega 7 ® reduces the risk of cardiovascular diseases. (Johansson et al, 2000;Yang, 2001; Yang and Kallio, 2002; Eccleston et al, 2002) Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com Omega 7 has ® anti-inflammatory and anti-analgesic properties Omega 7 is anti-inflammatory Oils from seed and pulp/peel of Sea Buckthorn (Hippophaë Rhamnoides) berries have been traditionally used in the treatment of skin disorders. Topical application of the oils promotes the healing process of burns,, scalds,, wounds of skin and radio dermatitis. In previous study the oils (Omega 7 ® irit dermatitis. Sea Buckthorn Oils are rich in phytosterols, tocopherols, tocotrienols and carotenoids. These components are probably responsible for the anti-inflammatory effects of the oils. The anti-inflammatory and anti-analgesic effect of the ® Omega 7 was studied by different animal ex®erimental models. Topically applied Omega 7 significantly alleviated®inflammation. The results of the test, where Omega 7 was orally administrated, suggested also significant analgesic effect of the oils. Kalloand Yang etall2001)) Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com Omega 7 enhances microcirculation Microcirculation refers to the blood circulation of the smallest blood vessels (diameter <100µm) of the body. Due to its crucial function in the exchange of substances, ,doosaussiewtsdbiuqilsag microcirculation plays a vital role in the physiology of the whole body. The effects of supercritical CO2-extracted sea buckthorn seed oil (SBSO) and pulp oil (SBPO) on microcirculation were investigated using two independent experimental models. In the animal auricular microcirculation model, topical application of SBSO and SBPO on the ear, once or twice per day, for three days increased the count of capillary net intersections by 17-41% and venular calibers by 11-25% on auricular area. Application of SBPPO ttwice pper daay for threee daays increaseed thee arteriolar calibers by 55%. In the mesenteric microcirculation model, a ten-minute immersion of mesenteries in 1-2% SBPO or SBSO in the Locke solution increased the count of mesenteric capillary net intersections by 22-41% and venular calibers by 11-25%. Immersion in 2% SBPO resulted in an increase of 25% in the mesenteric arteriolar calibers. These effects of sea buckthorn oils were found to be statisticy sgnificant yy comparisons carried out between the corresponding values before and after treatment as well as between sea buckthorn oil-treated groups and the negative control groups, i.e. the group treated with distilled water in auricular microcirculation model and the group treated with 100% Locke solution in mesenteric microcirculation model. The effects of sea buckthorn oils were dose responsive in both models. The results suggest that irpercriticaCOO2-ettracted sea brckthorn seed andd pl lp oils have great potential in improving microcirculation. Good microcirculation is important also to the skin Disorder in microcirculation has been shown to be a key sinflammation, cardiovascular disease and diabetes. Impeded microcirculation is also an important factor in skin problems such as couperosa and cellulite. Oxidation stress is often the major cause of damage to the microcirculation system. Antioxidants such as vitamin C and vitamin E have been shown to improve microcirculation. Sea Buckthorn seed oil and pulp oil are rich in natural tocopherols, tocotrienols, and carotenoids, which synergistically protect the cellular components from oxidation damage . (Yang et al., 2007) Aromtech Ltd Tel: +358 207 789 020 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com ® Omega 7 improves gastric ulcer Sea Buckthorn (Hippophaë rhamnoides)sia eie berry with exceptionally high contents of nutrients and phytochemicals such as lipids, water and fat soluble vitamins and flavonoids. The total antioxidative capacity of the berry is due to the presence of vitamins C and E, oyovtosuperoxide dismutase isoenzymes. The berries have a long hhisory oof appllcaton ((moore than 110000 yeaars) nin Tibetan and Mongolian medicines in the treatment of various diseases. Oils extracted from sea buckthorn berries have been used for treating scalds, burns and other skin injuries. In the following study, the effects of supercritical CO 2 extracted Sea Buckthorn Seed and Pulp oils on gastric ulcerrwere investigated forthe frst tmee. The effect of CO -2xtracted Sea Buckthorn Seed and Pulp Oils on the gastric ulcers in four experimental models was studied. The results showed both protective and curative effects of the oils. Even though the fatty acid compositions of the two oils are very divergent, no significant differences were observed in the gastric protecctve effects ofthe twoo ois.Thee essultsugggest haat the antiulcer effects of the tested Sea Buckthorn Oils may not have been due to their fatty acids only. The oils contain high levels of beta-carotene, alfa-tocopherol and beta-sitosterone, of which the latter one has shown to have curative effects on ulcer in previous studies. Sitosterol is also reported to increase the gastric protective activity of unsaturated phospholipids. In addditon,,evidencce exiss shoowing thattaddministraton oof Sea Buckthorn Oil inhibits lipid peroxidation in gastric mucosa in experimental models of gastric ulcer. The antiulcer activity of Sea Buckthorn Oils may be related to an increas in the hydrophobicity of the mucosal surface, retarding the gastric emptying process, inhibiting proteolytic activity in gastric liquid and promoting the wound reparation processes of mucosa. (Yang et al., 2002) Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 Finland10 Kiviranta www.aromtech.commtech.com REFERENCES Eccleston C, Yang B, Tahvonen R, Kallio H, Rimbach G, and Minihane A (2002). Effects of an antioxidant-rich juice (sea buckthorn) on risk factors for coronary heart disease in humans. J. Nutr. Biochem. 13, 346-354. Erkkola R and Yang B (2003) Sea Buckthorn oils: towards healthy mucous membranes. AgroFood industry hi-tech. 3, 53-57. Le Bell A-M, Söderling E, Rantanen I, Yang B, Kallio H.(2001) Effects of sea buckthorn oil on the oral mucosa of Sggren'sysyndrompe patientp: a pilot study Johansson A.K, Korte H, Yang B,Stanley J.C, Kallio H.P (2000) Sea 495kthorn berry oil inhibits platelet aggregation. J.Nutr.Biochem.11, 491- Yang B (2001) Lipophilic components of seeds and berries of sea buckthorn (Hippophaë rhamnoides) and physiological effects of sea buckthorn oils YanggB annd Kallo H (20033)Effects ofseabbucckthornooiionsskin.AsiaPPaciicfiic PERSONAL CARE 4 (5), 46-49 Yang B, Gunstone F, and Kallio H (2003) Oils containing oleic acid, palmitoleic acid, -linolenic acid and stearidonic acid. In: LIPIDS FOR FUNCTIONAL FOODS AND NUTRACEUTICALS. ISBN 0-9531949-3-0 Gunstone FD, ed. pp. 263-290, the Oily Press, Bridgwater, Uk. Yang B and Kallio H (2002) Composition and physiological effects of sea buckthorn (Hippophaë) lipids. Trends Food Sci. Technol. 13, 160-167. Yang B, Kalimo K, Mattila L, Kallio S, Katajisto J, Peltola O, and Kallio H (1999) Effects of dietary supplementation with sea buckthorn (Hippophaë rhamnoides) seed and pulp oils on atopic dermatitis. J. Nutr. Biochem. 10, 622-630. Xing J, Yang B, Dong Y,Wang B, Wang J, and Kallio H (2002). Effects of sea buckthorn (Hippophaë rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats. Fitoterapia 73, 644-650 Yangg,B.Effecttoforalsuupplemeentatton wiih capsules ofsuppercrricalCO22 extracted sea buckthorn (Hippophaë rhamnoides) oil on mucous membranes of patients of Sjögren's syndrome. 97th AOCS Annual Meeting&Expo 2006, April 30-May 3, St.Louis, Missouri, USA Yang B, Wu Y, Liu Q, Wang B, Kang J, Wang J, Kallio H. Supercritical CO2 extracted sea buckthorn pulp oil andseed oil improve microcirculation. In: Singh, V.; Yang, B.; Kallio, H.; Bala, M.; Sawhney, R.C.; Gupta, Mörsel, J.-T.; R.K.; Lu, R.; Tolkachev, O.N. (Eds.)2007. Seabuckthorn (Hippophae L.). A Multipurpose Wonder Plant. Vol. III: Advances in Research and Development, Dya Publishing House, New Delhi, India. Translation of OMEGA-7 case reports Omega-7 presentations Instrumental evaluation of skin hydration, elasticity, luminosity, roughness and thickness and subjective evaluation of a treatment by Omega 7 Sea Buckthorn Oil capsules Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com TECHNICAL DATA ® Omega 7 Sea Buckthorn Oil Capsule Technical data Ingredients SBA24 Sea Buckthorn Oil (72.2%) (Supercritical CO2Extract); Capsule shell material (modified maize starch, glycerol, gelling agent carrageenan, acidityregulator disodium phosphate); Antioxidant (alpha- tocopherol) Free of yeast, sugar and gluten. Suitable for vegetarians. Nutritional information 100 g 2-4 caps. Energy 735 kcal/3029kj 10.1-20.2 kcal/42-84 kj Protein 0 g 0 g Carbohydrate 23.0 g 0.32-0.64 g Fat 72.2 g 1.00-2.00 g Of which: Saturated fatty acids 18.8 g 0.26-0.52 g Monounsaturated fatty acids 30.3 g 0.42-0.84 g Of which: Palmitoleic acid (16:1n-7) 17.3 g 0.24-0.48 cis-Vaccenic acid (18:1n-7) 4.3 g 0.06-0.12 Oleic acid (18:1n-9) 8.7 g 0.12-0.24 g Polyunsaturated fatty acids 23.1 g 0.32-0.64 g Of which: Omega-3 fatty acids 10.1 g 0.14-0.28 g Of which: Alpha linolenic acid (18:3n-3) 10.1 g 0.14-0.28 g Omeega-6 faty acids 13.0 g 0.88-0.36 g Of which: Linoleic acid (18:2n-6) 13.0 g 0.18-0.36 g Vitamin E (alpha tocopherol) 0.29 g 4.0-8.0 mg* *40 - 80% of Recommended Daily Intake Manufactured by Aromtech Ltd,95410 Kiviranta / Tornio, Finland Aromtech Ltd Tel: +358 207 789 020 Veturitallintie 1 Fax: +358 207 789 028 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com ® Efficacy of Omega 7 on SKIN – customer testimonials I will always love sea buckthorn Irene Tarkka, a real estate agent from Kirkkonummi , Finland, had an itchy rash above her ankle a few years back. The rash proved very hard to get rid of. Cortisone and other ointments only made it worse. With Omega-7 sea buckthorn oil capsuples from the health shop the terrible itch and the entire rash vanished in a couple of days. Terveyshymy (Finland), 2003. Atopy settled and muscular pain vanished Top orienteerer found the answer to her problems in Lappish herbs and Omega-7 Sea Buckthorn Capsules. For years,TeerhiHoosterrhassbeeen oneeoffthe worrd's op sports women in orienteering on and off skis. She will be qualifying as a natural therapist and she feels that nature has offered her solutions to her problems. Atopic eczema was one of the problems and it almost destroyed her joy of life. ”Now, the atopic eczema has completely vanished and my muscles are also well taken care of”. Terveyshymy (Finland), 2003. Aromtech Ltd Tel: +358 207 789 020 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com Efficacy of Omega 7 ® on MUCOUS MEMBRANES – customer testimonials I have stopped taking saliva stimulating pills Kajsa Andersson, 38, got symptoms of dryness of the mouth in connection with her menopause. A friend told her about Membrasin (Omega-7). “I tried it and started to feel the effects after 2-3 weeks of use. I was no longer depenpdent on all the previous treatments I had undergone to relieve the symptoms, because my mucous membranes felt moist without the treatments. I soon stopped taking pills for stimulating saliva secretion, of which I had been completely dependent before. I no longer feel totally dried out: I feel normal. What is the best is that my entire quality of life improved. I feel more energetic, more harmonious and feel altogether much better.” AFTONBLADET Hälsa (Sweden), 2002. Stine no longer suffers of tired eyes Stine has always suffered of dry and tired eyes. Stine tried Membrasin (Omega-7) hoping that it would solve her problem. It became clear that the problem was not poor eyesight but dry mucous membranes. Stine experienced a great improvement after she began taking the product. She has taken the capsules for three months today. She no longer has any problems in reading, and the urinal infections she suffered of before have also vanished. “After one month's use, I began to feel a change in the muccous meembbraness nmy nnose and eyes. They no longer felt dry and irritated and I could much better concentrate my eyes when reading. The improvement continued and the symptoms had totally disappeared after two months. I still take two capsules a day to keep the symptoms from reappearing. I have now read more about sea buckthorn and the fatty acids the plant contains” (Stine). AFTONBLADET Hälsa (Sweden), 2002. Aromtech Ltd Tel: +358 207 789 020 FIN-95410 Kiviranta E-mail: firstname.lastname@example.org Finland www.aromtech.com ® Efficacy ofOmega 7 on MUCOUS MEMBRANES – customer testimonials Sex doesn`t hurt any more Jennifer, 47, has suffered from an embarrassing but common problem for two years, which has had a disastrous effect on her sex life. But an ancient remedy traditionally used in Tibetan and Mongolian medicine has come to her rescue. “I am going through the menopause... I begun taking Omega-7 in January and a month later I began to see a difference. I did not feel as dry as I used to and my skin looked a lot better. I`ve taken it ever since. Sex doesn`t hurt any more, so my husband and I can enjoy a healthy sex life again” (Jennifer). Woman (UK), 2003. Now I will never leave out sea buckthorn capsules Carin Bergström, 57, from Stockholm was looking for something which could help her dry and sensitive eye problem. When she started taking capsules based on sea buckthorn she observed that they were useful for other mucous membranes of the body. “During the daytime when I was outside, my eyes were running. At night they became so dry and sensitive that it hurt to open them. For eyelids I found synthetic eyedrops and cream which helped a little but did not cure the whole problem. So when my daughter mentioned that a new natural product designed for dry mucosa had become available, I wanted to test it. And it turned out to be a lucky choice,” says Carin Bergström. Now she has taken Membrasin (Omega-7), a food supplement based on sea buckthorn, for more than a year. She cannot imagine dropping off the capsules. -Now, when I found something which helps so well, I don't ever wanttto quit,she says.. Hjemmet, 2004. Aromtech Ltd Tel: +358 207 789 020 FIN-95410 Kiviranta E-mail: email@example.com Finland www.aromtech.com
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