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Marc Hens, PhD Durham, NC 27705 919-323-6402, email@example.com Summary of Skills Analyzed organic and bioactive compounds utilizing chromatography, spectroscopy, and spectrophotometry techniques including HPLC, LC/MS, MALDI-TOF, DART-MS Method Development and validation Small molecule, incl. heterocyclic compounds, synthesis Peptide synthesis, peptide and protein isolation, modification, and immunoassays Radiochemistry and radiolabeling of compounds, peptides, and proteins with I-125/131, Lu-177, In-111, F-18, At-211 Education Dept. of Organic Chemistry, University Duisburg-Essen, Germany, PhD 2001 Thesis title “Cycloaddition reactions of two moderately electron deficient -heteroatom substituted propenoic acid derivatives” Dept. of Organic Chemistry, University Duisburg-Essen, Germany, MSc 1995 Thesis title “About 3-methyl-5-methylene-2-thioxothiazolidin-4-one in cycloaddition reactions” American Management Association Certificate in Finance and Accounting, Durham Technical Community College, Durham, NC Currently enrolled in ‘GMP and SOP’ course at Durham Technical Community College, Durham, NC Professional Experience Global Laboratory Services, Inc., Wilson, NC Contract Analytical Chemist 06/2012– 08/2012 Successfully developed HPLC methods for the detection and quantification of tobacco contaminants under ISO 17025 Increased sample throughput more than two-fold International Technology Center, Inc., Raleigh, NC Organic Chemistry Consultant, Nanoparticles 11/2011 – 05/2012 Modified nanodiamonds for chemical and biochemical applications Devised synthetic strategies to modify nanodiamonds for use in biochemical and other applications Duke University Medical Center, Department of Radiology, Durham, NC Postdoctoral/Sr. Research Associate 04/2004 – 10/2011 Mass spectrometric analysis, and other spectroscopic/spectrophotometric analysis of compounds, peptides, proteins and conjugates Peptide synthesis, labeled monoclonal antibodies, peptides and small molecules with radioisotopes Synthesis of small molecules suitable for radiochemical labeling Administering and managing chemical inventory including ordering of chemicals Surfacine Development Company, LLC, Tyngsboro, MA Formulations Chemistry Consultant 05/2003 – 03/2004 ® Formulated new products at customers laboratories incorporating Surfacine technology Solved technical problems for industrial clients on formulating Surfacine technology Patent and literature research Massachusetts College of Pharmacy, Boston, MA Research Assistant Professor 05/2002 – 04/2003 Synthesized and characterized novel SSRI inhibitors for potential cocaine abuse treatment Surfacine Development Company, LLC, Tyngsboro, MA (operations closed in 02/2002) Formulations Chemist 01/2001 – 02/2002 Synthesized cross-linked PHMB polymers for use in antimicrobial formulations Formulated Surfacine products according to customer specifications Developed and improved formulation chemistry resulting in lowered cost, reduced VOC and extended shelf-life Provided assistance for EPA regulatory approval of Surfacine antimicrobial applications ® Supplied technical support to Surfacine customers Wrote reports, SOP’s, and MSDS for Surfacine products University Duisburg-Essen, Duisburg, Germany Graduate Student 10/1995 – 04/2000 Designed, synthesized and evaluated small molecules as probes for mechanistic studies Supervised advanced undergraduate organic synthetic laboratory courses Gained knowledge and expertise in heterocyclic, fluorine and wet chemistry Acquired knowledge of analytical instrumentation (NMR, FTIR, UV/VIS, GC, GC/MS) and chemical database research (CAS, Gmelin, Beilstein) and patent database research Kyoto University, Kyoto, Japan Graduate Student 04/1997 – 03/1999 Performed synthesis of small molecules via multi-step synthesis Continued investigation of small molecules as probes for mechanistic studies Awards Awarded Monbusho Japanese Government Scholarship 04/1997 – 03/1999 Awarded German Academic Exchange Service (DAAD) Scholarship 04/1997 – 03/1999 Publications 177 Anti-EGFRvIII monoclonal antibody armed with Lu: in vivo comparison of macrocyclic and acyclic ligands Hens, M., Vaidyanathan, G., Zhao, X.-G., Bigner, D.A., Zalutsky, M. Nuclear Medicine and Biology, Volume 37(7), 2010, 741-750 177 Labeling Internalizing Anti-Epidermal Growth Factor Receptor Variant III Monoclonal Antibody with Lu: In Vitro Comparison of Acyclic and Macrocyclic Ligands Hens, M., Vaidyanathan, G., Welsh, P., Zalutsky, M.R. Nuclear Medicine and Biology, Volume 36(2), 2009, 117-128 177 Antitenascin antibody 81C6 armed with Lu: in vivo comparison of macrocyclic and acyclic ligands Yordanov, A.T., Hens, M., Pegram, C., Bigner, D.D., Zalutsky, M.R. Nuclear Medicine and Biology, Volume 34(2), 2007, 173-183 A Kit Method for the High Level Synthesis of [211At]MABG Vaidyanathan, G., Affleck, D.J., Alston, K.L., Zhao, X.G., Hens, M., Hunter, D.H., Babich, J., Zalutsky, M.R. Bioorganic & Medicinal Chemistry, Volume 15(10), 2007, 3430-3436 Effect of linker sequence on internalization properties of Lu-177 labeled somatostatin analogues Balter, H.S., Hens, M., Welsh, P., Affleck, D., Zalutsky, M.R. Alasbimn Journal 8(31), 2006 Presentations th 17 International Symposium on Radiopharmaceutical Sciences, Aachen, Germany 4/30 – 5/4 2007 “An Internalizing Anti-EGFRvIII Monoclonal Antibody Labeled With 17Lu: Effect Of Chelating Agent On Intracellular Retention” Marc Hens p. 2