Review Sheet for BIOC 462A at UA
Review Sheet for BIOC 462A at UA
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Date Created: 02/06/15
Dossier Steroid receptors Biomed Pharmacother 2002 56 847 2002 Editions scienti ques et me dicales Elsevier SAS All rights reserved SO753332201001585FLA Resveratrol and cancer a review JF Savouret M Quesne INSERM unite 135 Hopital de Bic tre CHU level 3 7 8 rue du Ge39ne39ral Leclerc 94270 Le KremlinBic tre France Received 15 October 2001 accepted 5 November 2001 Summary The various properties of the stilbene phytoalexin Resveratrol provide interesting new avenues of research in the field of chemoprevention and chemotherapy A particular emphasis is given on xenobioticrelated carcinogenesis 2002 Editions scientifiques et medicales Elsevier SAS aryl hydrocarbon receptor chemoprevention resveratrol The wealth of literature on polyphenols or avonoids and cancer is in strong contrast with the absence at this time of an established use of any such molecule either as chemoprevention or chemotherapy Such a paradox may however not last much longer if res veratrol the latest discovery in the eld receives clinical con rmation of its promising experimental properties Resveratrol has been known for centuries in Asian medicine as Kojokon in the form of the powdered root of Polygonum cuspidazum as an anti in ammatory drug 1 However its interest in the eld of cancer therapy is much more recent 2 Other recent reviews may help the reader in his estimation of the interest of resveratrol 3 4 In accordance with the multiple properties of resveratrol against tumorigenesis we have separated in our description the antixenobiotic properties antiinitiation from the more general cellular effects of this drug anti promotion and antiprogression Finally we will stress the advantages of resveratrol over previously described avonoids RE SVERATROL Resveratrol and avonoids evolve from a common synthesis pathway in plants Only plants can trans Correspondence and reprints Email addrer savouretkbinsermfr J F Savouret form phenylalanin into hydroxycinnamoic acid Then depending on the number of cinnamoyl radi cals combined chalcone synthase can use three to produce avonoids while pinosylvin synthase stil bene synthase uses two to make resveratrol also known as 354 trihydroxystilbene Resveratrol is a phytoalexin used by plants to defend themselves from fungal and other forms of aggression As it is expressed in grapes skin upon attack by Bothrytis cinema it is found in red wine in substantial amounts 4720 mgL 5 6 RESVERATROL AND XENOBIOTIC CARCINOGEN S Phase I cytochromes Resveratrol displays numerous properties related to very different mechanisms of action However the antiinitiation effects appear to us as essentially related to its antixenobiotic abilities As a polyphenol resveratrol is an antioxidant and a free radical scavenger It has therefore been sus pected to be responsible for the cardioprotective effects of red wine dubbed the French paradox 79 On the other hand tobacco smoke contains high amounts of aryl hydrocarbon and dioxin receptor AhR ligands such as Benzoapyrene BaP and anthracenes and smoking is a core problem in car diovascular diseases but also in at least eight differ
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