Class Note for MIC 205A at UA
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This 3 page Class Notes was uploaded by an elite notetaker on Friday February 6, 2015. The Class Notes belongs to a course at University of Arizona taught by a professor in Fall. Since its upload, it has received 14 views.
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Date Created: 02/06/15
Drugs Microbes Host The Elements of Chemotherapy Antibiotics Still Miracle Drugs Paul Ehrlich s Magic Bullets Fleming and Penicillin Antibiotics Topics Antimicrobial Therapy Selective Toxicity Survey of Antimicrobial Drugs Microbial Drug Resistance Drug and Host Interaction Characteristics of the Ideal Antimicrobial Drug Sulemwly lam lo the micruhe bu nuntndk m hml re 39 Miami dal mlhur llhm minubishnic Relatively soluble luncliuns mu when highly dlhllul in body hum Remains potent Ion enough to Ad and is mu bmkm sluwn m uxm lml prematurer o Ducm39t lead to the dcvclupmunl ul dnlimiCrubidl rcigtlanm I Complement or a a the activities 0 he has Rcmmm achvu in mum and hd uid I Readily delivered to the site of infection Ramona ly prim Due nn dimlpl the how health by musing Allergies ur predisposing the hum lomlwr infections duhquotsea Turnlnnlogy nl chrmoumupy lwmwlhrranmlirdmg h mwm nllmml Kenamenquot Myqul Amth hmnynllruk drum whth amu wa mum mm mm mm mm l hum Mmlm aml W Mm Mlun Antibiotics Naturally occurring antimicrobials Metabolic products of bacteria and fungi Reduce competition for nutrients and space Bacteria that produce them Streptomyces Bacillus Molds Penicillium Cephalosporium Selective Toxicity Drugs that speci cally target microbial processes and not the human host cellular processes Selective Toxicity Mechanisms and sites Mechanism of action Bacterial cell wall Nucleic acid synthesis Protein synthesis Cell membrane Folic acid synthesis Oeiiwil Emkivnihwm m mm alumna Vanwmwin amm wmmm an Gammons quot i Wham summ mmmmmmmpw yanst i mm gym Wm nnxnmsl minim lunmlloxmnl mi HNAwamus mm nmmyersm Yulmnvzlins mu mmquot antmm WWW Cell wall synthesis Badenddd Penicillin and cephalosporins binds and blocks peptidases involved in crosslinking the glycan molecules Vancomycin hinders peptidoglycan Honga on Cyclosen39ne inhibits the formation of the basic peptidoglycan subunits Antibiutics Weaken the cell Wall and cause the cell to lyse The mechanism at aetieh er penicillin and eephaiespehhs Penicillin Penicillin chrysogenum A diverse group 15 2quot 339 generations Natural penicillin G and V Semisynthetic Ampicillin Carbenicillin Structure Thiazolidine ring Betalactam ring Variable side chain R group Chemical structure of penicillins The R group is responsible rm the activity at the Penicillinase 3 Lactamase New drug and cleavage at the i A M REwmcScw Warmer mg Recehhe hikkm Wilm at Af w Will rendertne 039 A N drug inactive Pmimn Pruimwwwm Cephalosporin m Wmi mm The gimme cephalosponum acremonlum mold fcephduspmns Widely administered today Diverse group natural and semisynthetic Th M l WW 15 2quot and 339 generations R gimp N law 3 k WNW alluwlur I7 39 m Structure WNW mks s w cry Lurk similar to penicillin except 33mg o Main ring is different KOCH h hwmh Two sites for R groups mm 739quot