Class Note for MIC 205A at UA 2
Class Note for MIC 205A at UA 2
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This 13 page Class Notes was uploaded by an elite notetaker on Friday February 6, 2015. The Class Notes belongs to a course at University of Arizona taught by a professor in Fall. Since its upload, it has received 18 views.
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Date Created: 02/06/15
Infectious Diseases of the Cardiovascular and Lymphatic Systems The Cardiovascular System Heart Blood vessels Lymphatics Lymph nodes spleen MALT RBC WBC Monocyte9Macrophage T B NK lymphocytes The Blood carries 02 CO239 nutrients Cells plasma Infectious agents in the blood Bacteremia lviremia bacteria lviruses in blood Septicemia growth of bacteria in blood Septic shock 9 endotoxin LPS release 9 macrophage cytokines 9 low blood pressure leaky capillaries 9 high fever Cardiovascular System Defenses Defensins antimicrobial proteins in lysosomes of phagocytic cells Neutrophils antibodies complement Filtering function of Lymph Nodes No normal flora Transient flora Infectious agents in blood are systemic Selected Bacterial Infections of the Blood 0 Plague Yersinia pestis Lyme Disease Borrelia burgdorferi 0 Rocky Mountain Spotted Fever Rickettsia rickettsii Yersinia pestis Cause of Plague Gram negative rod Grows in digestive tract of flea vector Reservoir is rodents prairie dogs Endemic above 4000 ft elevation in Arizona The infection cycle of Yersinia pestis Animal Reservoirs United States MAMMALS KNOWN i OiMR nRi iACUP N iliFUNi my 5mm Cmmwms Eiatk hm unis Unduzimghahmlsand maunmin my Eaas dag iaxus mmquot mtmaiisskunks 9595 wnimi mesmm mm Chipmunks gaphers mums mite pimiiedags migsqmiieis wigs Lngainmphs Hams rabbits named Stank Figs mule we pranghmu mlsiape Runrind in m l mum Plague in Arizona Prairie Dog Plague Flagstaff 2001 99 colonies observed 49 colonies experienced gt99 mortality MaySeptember 2001 Y pestis confirmed as cause of die offs at 19 colonies Bubonic Plague Transmitted by ea bite Y pestis enters blood and grows in macrophages in lymph nodes Swollen lymph nodes are buboes Septicemic plague Plague proliferation in blood endotoxin shock Pneumonic plague lung infection 100 mortality spread by droplets Curable with antibiotic if diagnosed quickly F Lyme Disease Primary Lesion g 1 bullseye rash on skin 3 Secondary lesion ulike symptoms neurological symptoms Tertiary lesion in ammation of large Lyme Arthritis Immune system Type III hypersensitivity to 9 persisting antigen 9 antigenantibody complexes 9 in ammation tissue damage by neutrophils Treated with antibiotics Lyme Disease is caused by Barrela burgdorferi Spirochetes are very narrow spiralshaped bacteria Gram negative Motile A ei Willy Euvgduriev Lyme Disease Vectors Tick vector bites infected reservoir deer mouse and becomes infected transmits disease to humans through bites Cycle of infection W 4th B burgdorferi Disease emerged when humans moved into tickreservoir environment Rocky Mountain Spotted Fever Fever chills headache muscle pain Red 9 black rash Transmitted to humans by tick bites Now found mostly in Eastern Atlantic states 7 Rickettsia rickettsii Gram negative bacillus or coccobacillus Obligate intracellular parasite Rickettsia and Obligate Intracellular Parasitism Bind to cell surface and are taken into endothelial cells by phagocylosis Escape from phagosome into cytoplasm Have ETC Obtain nutrients NAD and CoA from host Cause capillaries to degrade Vectors Wood Tick and Dog Tick RMSF Rocky Mountain Spotted Fever Treatable with antibiotics Diagnosed using fluorescent antibodies on tissue samples PCR 20 of untreated cases and 510 of treated cases are fatal Some Virus Infections of the Cardiovascular System Persistent Herpesviruses Human herpes viruses 45678 Viral hemorrhagic Fevers Yeow Fever Dengue Fever Ebola Lassa Fever HIV Virus Infections of the Cardiovascular System Persistent HerpesVIruses In lymphoc es Human Herpes4 Mununucleusis Epsteln Elarrvirus Menu infectiuus Menu Human Herpes 5 Cvtumegaluvirus Cyturnegaluvirus lnclusiun Disease Human HerpesE Ruseula Human Herpes7 7 Human Herpes a Kapusi s Sarcurna in Ale patients Infectious mononucleosis infects a lvmpnucytes 7 viral latency in a lvmpnucytes A cause ulChmmcfatlguE synuiume7 C omegalovims Inclusion Disease Newburns rarely A cause er mental retardatiun viral latencvis in lvmpnucytes and kidney cells Severe irirecticiri iri irnrnuriciccirnprcirnised patient Hlv Cancer arid transplant patients immi uam Viral Hemorrhagic fevers Viral infection Reservciir Lunatiun Yellow fever Aedes agypll CemArrica 5 America Den gue fever Aedes agypll WurlerldE Trupical Ebola Fruit Elat Cent Arrica Lassa fever Rudent WestAfrica Viral Hemorrhagic fevers Capillary fragility and leakage Disruption of the blood clotting system a Bleeding Hemorrhage Liver damage Hepatitis e High Fatality rate Human immunodeficiency virus HIV BloodBorne Viral infection Infects helper T lymphocytes CD4 receptor Acquired immunodeficiency syndrome Long Latent incubation period Hiv has speci c glycoproteiri receptors that bind to CD4 receptors ofT ceiis 10 Four main stages of an HIV infection Level of virus aniigen Level of anlibeuies in one or more antigens Level of CD4 T cells 1 gt500 cellsul E n e a e E o o 1 S lt2oo E quot cellspl e e 2 E E 0 g z 0 Q Venable number 2 weeks Variabie number of years 7 AIDS Infecllan 2 monlhs l Ill Stages of an HIV infection Level er virus anligen Level of antibodies lo one or more antigens Level or CD4 T cells 1 gt500 cellsul N E n e a e E o o 1 S lt2oo 53 quot cellspl e e 2 E E g z 0 Q Venable number 2 weeks Variable number at years 7 AIDS Inlecllcn 2 menth I III 39 Sources and routes of infection by HIV Dilncimwdnwusum 5mquot mum Inillciad ummnml umxnwm mama Blood injection Illimcmllsualavwl mmwlumu II STD lllIIllqu wllIuLI IllINLuuluu IV drug use I manuals MSM Prostitution Heterosexual Jae mmu cDIIs mvmlvmq 5km mum mm nlnyliliy vim 11 Some important secondary infections in AIDS AIDSDe ning Illnesses Skln andor Genitourinary Mucous Cardiovascularand mudor Membranes Nervnus Lymph System a Rexpimury Gaslmlnleslinal Reproduclive in ex Syncquot Multiple Orgln Systems Trm Trm Tract Cryplnmm Cmimmymsimissumm Cundidiusism Cindxdilsisof Invasivemvicai primarily owmpnlmmry oresopmgms dunhon W W WWW sanmm quotwhim Mywbudmum Jami Tubzmnlvsis 15mm chmi dissenurmedw mmpmmmul chmcimesm m Wasdngsyndmrme AIDS and Herpesvirusesan example Kaposi s Sarcoma caused by Human Herpes 8 f HHV8 causes a mixed cell tumor of Lymphocytes fibroblasts and blood vessels On the skin esophagus and many other sites Nucleoside analogs and protease inhibitors are effective therapies used to treat HIV infections VHUS cannul prnduce lt new iniecuons Ji eteclive Virus vvaIDNA m quot9quot 39 E39F N 39 I 1 Hevsvse v iranscnpiase Praiease Inhibitor H v No complete vira DNA AZT 1v pmiease Wurid imam 5a u ms HIV may lt 39 273 7 W Transmission 95 m 5 quotanquot ogtlt u in US compared To the World 39 225 W m a 4 W 491 aw WWWquot l n HIVAIDS prevalence in the world Regional HIVAIDS Slalislicx and Feaiurzx 2002 Estimated Estimated Adults and Children MMIB and Children Living wilih HIVAIDS Newly lnlened with HIV SubSaharan A n 294 milliun 5 5 million Nunli Aliinn and Middla Eas 550000 33000 Sculli and SouiiieaalAsia 60 million 70171100 Easi Asia and Paci c 12 million 270000 Latin America 15 million 150000 anbaan 440 000 60000 mm Europe and Ccnhal Asia 12 minim 250000 Wesiemaum 57mm 3mm Nunli Alumina 980000 45000 Australia and New Zealand 15000 500 OTAL 42 million 5 million HIVAIDS prevalence In the world Regional HIVAIDS Statistic and Features 2002 Estimated Enlmaled Adults and Children Adulis and Childnn Living wilih HIVAIDS Newly Inleded wiih HIV Na cm mums 53000 South and Souiheasx Asia 7DD0C0 East Asia and Pacific 270000 Latin Amenca 150000 Caribbean 60000 mm Empdeemimi 250000 aumo Nonli Aniama 450DU Zealand 500 TOTAL 5 million 13
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