Note for MCB 411 at UA
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This 2 page Class Notes was uploaded by an elite notetaker on Friday February 6, 2015. The Class Notes belongs to a course at University of Arizona taught by a professor in Fall. Since its upload, it has received 14 views.
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Date Created: 02/06/15
MCB41 lkey concepts Molecular world A Molecules interact primarily on the basis of hydrogen bonds salt bridges and waterfreeing hydrophobic interactions B Molecular machines cannot think their amino acid composition and 3D shape must specify their every behavior C Energy of ATP resides in comprehensible features such as apposition of charges in the phosphate NOT high energy bonds magic or mystery D An enzyme is a molecule that makes chemical reactions more ef cient w A Bases pair because of chemical complementarity size shape and number of hydrogen bonds between bases FAILURE of bases to pair with nonpartners is a critical component of information in DNA B DNA is a selfstructuring molecule innately capable of bearing information C DNA is chemically superior to RNA on the basis of greater backbone stability and in encoding a clue 5methyl on T that allows detection of C gt U deamination D DNA Polymerase works simply using complementarity of the bases themselves to choose substrates DNA Polymerase realizes mistakes by relying upon primer s 339 base39s ability to pair with template E Structure of DNA allows for ef cient inheritance and encoding of information F Alterations in DNA seq can have consequences to the organism because information is altered Transcription A What is a gene A gene is a string of nucleotides which speci es when where a gene product should be made by directing synthesis of an RNA molecule Some RNA molecules contain the information for determining the primary sequence of the protein encoded by that RNA B Some DNA encodes signals in the form of speci c sequences bound by proteins that bring about RNA Polymerase assembly binding and therefore cause transcription to happen or not to happen C Some of the RNA molecules directly function in cellular processes while others are translated into proteins that mediate cellular functions Translation A The rst critical step in translation is recognizing the initiating codon AUG that sets the reading frame for the whole message B The mechanism by which codons are interpreted as amino acids involves a tRNA that can interact directly with the message to decode it and a molecular machine to carry out the process C tRNA synthetases determine which aa are placed onto the appropriate tRNA D protein folding determines the 3d structure and therefore the properties of the protein and proteins are normally organized into functional domains Global Regulation A At every step of protein biogenesis starting with replication there are mechanisms ensuring accuracy and destruction of misproduced products Yet disease and evolution still happen B Chemical modifications of proteins can lead to alterations in their properties
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