Class Note for BME 510 at UA
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This 2 page Class Notes was uploaded by an elite notetaker on Friday February 6, 2015. The Class Notes belongs to a course at University of Arizona taught by a professor in Fall. Since its upload, it has received 17 views.
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Date Created: 02/06/15
BME 510 Maior concepts from each lectureI Oct 31Dec 5I 2008 Lecture 26 Signaling Kinases 0 Control of signaling kinases via phosphorylation and dephosphorylation cyclin for cyclindependent kinases cyclic AMP for cAMPdependent kinases other mitogens for MAP kinases o Kinase signaling cascades multiple pathways 0 Study examples of kinases to reinforce main concepts Lecture 28 Signaling Gproteins o The general activation pathway the roles of each subunit 0 Desensitization o Inositol 145triphosphate IP3 0 Study examples of Gproteins to reinforce main concepts Lecture 31 Signaling JakSTATsI Apoptosis o The general activation pathway for Jaks and STAT5 0 Study examples of JakSTAT pathways to reinforce main concepts 0 The roles of procaspases and caspases in apoptosis 0 The general concept ofapoptosis inhibitors and promoters names of speci c molecules are not required Lecture 32 Cell Cycle 0 G1 S G2 and M phases Interphase prophase prometaphase metphase anaphase and telophase What happens during each of these phases 0 Cell cycle checkpoints and the role of cyclin o Meiosis meiosis II o Mechanisms during meiosis that promote genetic diversity Lecture 33 Cell Differentiation o 4 control mechanisms genes gene regulation eg pleiotropy methylation cellcell contact 0 Study examples of each ofthese control mechanisms to reinforce main concepts Lecture 34 Cancer 0 hyperplasia metaplasia dysplasia neoplasia and desmoplasia 0 Characteristics of benign and malignant tumors 0 Adenoma lipoma carcinoma sarcoma lymphomaleukemia o The general pathway of invasion and metastasis Lecture 35 Voltaqeqated Ion Channels and Membrane Current 0 Neuron structure and diversity of function 0 Ion channels and membrane current 0 Equilibrium potentials o Resting membrane potential Lecture 36 Electrical Properties of the Nerve Cell Membrane o Membrane capacitance and resistance 0 The equivalent circuit for a neuronal membrane 0 Temporal component of response to current the time constant 0 Spatial decay of current the length constant 0 Consequences for propagation of signals in real cells Lecture 37 Action Potentials and Conduction 0 Generation of action potentials o Voltageclamp and membrane currents underlying action potential 0 Sodium and potassium currents o Inactivation 0 Relationship to singlechannel currents Lecture 38 Chemical Synaptic Transmission 0 Synaptic structure and function general observations 0 Electrical response of the postsynaptic cell 0 Synaptic current and reversal potential 0 Role of calcium in release 0 Quantal nature of neurotransmitter release Lecture 39 Neuronal Control of Muscle Contraction o Sliding filament theory of muscle contraction o Energetics of muscle contraction o Motoneuronal control of muscle contraction
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