Class Note for BME 510 at UA 2
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This 12 page Class Notes was uploaded by an elite notetaker on Friday February 6, 2015. The Class Notes belongs to a course at University of Arizona taught by a professor in Fall. Since its upload, it has received 16 views.
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Date Created: 02/06/15
Voltagegated Ion Channels and Membrane Current Neuron structure and diversity of function lon channels and membrane current Equilibrium potentials Resting membrane potential Rick Levine rbl4emailarizonaedu Rm 427 Gould Simpson or 114 Gittings E iia L3 93935 5552123 zips Charge distribution at rest e We 9 696 e 9 Extraceiiuiar 9 e 9 0 Slde e 9 e Equai r e Lipid bilayer MM 999999999 Cympiasmic 69 e a 908 9 side Equai r Equai 5 Gating of Ion Channels Closed Open A Ugand ated JV Bind nganu Egdracellukar Q mplasmic SI 9 B Fhosphcrvlaticngaxed Phosphczylate gt Dephosphorylate C Vanagegats39d Change membrane pmsntial D snatch m pressuragated Sketch gt Cymskslelon Single Channel Current d an mm mm n7 4n i 50 mV Electrical and chemical gradients create quantifiable forces that move K ions These forces are equal and opposite at the K equilibrium potential EK The net K current across the membrane is determined by the Kconductance and by the driving force VmEK lon concentrations inside and outside a typical mammalian cell Intracellular mM Extracellular mM Cations Na 515 145 K 140 5 M92 05 12 Ca2 104 12 H 7 x 105 1072 M or pH 72 4 x 105 1074M or pH 74 Anions CI 515 110 tmceiiular side T 9N gt 9 in am gm kl 9x n c r48 8 m E E E 5 C J N T Cl T K J Name pump W Wiasmic side o cvlooiasmic side on distributions are enforced by ATPdependent pumps Since the membrane at rest is permeable to more than one ion no ion is at equilibrium The net steadystate current is determined by the driving force and conductance for each ion and will sum to zero when the membrane is at rest Membrane 50 polenlial or Vm mV T De polarized Resting potentialquot l Hyperpolarized 02 05 10 25 5 10 20 50 100 Extracellular K concentration or K D mM capmxamgmmsmmum Mummm GoldmanHodgkinKatz Equation RT PKIIout PNaNaout PCICIin V 1n M F P1Kin PNaN0in PC1C7 U1 httpWMANnernstgoldmanphysiologyarizonaedul
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