Class Note for MIC 205A at UA
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This 10 page Class Notes was uploaded by an elite notetaker on Friday February 6, 2015. The Class Notes belongs to a course at University of Arizona taught by a professor in Fall. Since its upload, it has received 14 views.
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Date Created: 02/06/15
Infectious Diseases of the Skin and Eyes Skin Structure Natural Defenses of the Skin Keratin Skin sloughing Sebum low pH high lipid Sweat low pH high salt and Lysozyme which digests peptidoglycan Normal Skin Flora Propionibacterium acnes Corynebacterium sp Staphylococci Staphylococcus epidermidis Staphylococcus aureus Streptococh sp Candida albicans yeast Many others The Eye Normal ora sparse Similarto skin ora Tears have lysozyme lgA Bacterial eye infection resulting from injury is a medical emergency Bacterial Skin Infections Acne Necrotizing fasciitis Leprosy Acne Propionibacterium acnes Gram rod Digests sebum Attracts neutrophils Neutrophil digestive enzymes cause lesions pus pocketsquot Microscopy Acne Most common skin disease in humans Oilbased cosmetics worsen disease No effects of diet Acne Treatments Benzoyl peroxide dries plugged follicles kills microbes Tetracycline antibiotic Accutane inhibits sebum formation Necrotizing Fasciitis Flesh Eating Strep Streptococcus pyogenes Group A Strep Tissue digesting enzymes Hyaluronidase Streptokinase Streptolysins Rapidly spreading cellulitis may lead to loss of limb Necrotizing Fasciitis Disease starts as localized infection Pain in area ulike symptoms Invasive and spreading May lead to toxic shock drop in blood pressure lncidence120100000 3070 mortality Surgical removal antibiotics Hansen s Disease Leprosy M ycobacterium Ieprae Disease of skin and nerves Change of pigmentation loss of sensation Slow progressing Transmits poorly Droplet or skin contact Hansen s Disease Leprosy M ycobacterium leprae Acid fast bacterium Slow growth Strict parasite Multiplies in macrophages Prefers cool areas of body Long course drug cocktail Virus Infections ofthe Skin Rashes Maculopapular rashes flat to slightly raised colored bump Measles virus Rubeola German Measles Human Herpesvirus 6 Fifth Disease Human Parvovirus B19 Rubella virus Roseola Measles Viral infection through aerosol droplet One ofthe MOST communicable viruses Initial infection ofthe oro pharynx 9 local infection lymph nodes ofthe neck 9 lymphocyte associated viremia Fever malaise 9 Spread throughout the body 9 Shed in respiratory tract secretions Koplik s spots Skin Rash 9 Recovery life long immunity Effective childhood vaccine 23 doses MMR measles mumps rubella but disease still exists worldWIde An example of the rash of measles Measles World Wide Measles is the leading cause ofvaccinepreventable death among children Millions of children still remain at risk 39om measles In developed measles death rates range 39om 15 but among malnourished children the death rate reaches 1030 Over 500000 children under the age of live die each year Measles causes health complications including pneumonia diarrhea encephalitis and corneal scarring The primary reason for ongoing high childhood deaths is the failure to deliver at least one dose of measles vaccine to all infants Measles World Wide Causes oi VaccinePievemable cniid Deaths in Africa AFRO 2000 I Measles ism void rm iaoti Nminunliilus idiom lyric iiw nomoi rwiamshsvd 39i wnaoang comquot mm The Measles Vaccine initiative 2001 American Red CrEISS United Nations Foundation UN Foundation United States Centersfur Disease Control and Prevention CDC vvoiid Heaitn organization WHO United Nations Chlidren s Fund UNlCEF Rubella Viral infection through aerosol droplet systemic infection A Mild rash Serious for a fetus when contracted in the first trimester of pregnancy Disrupts fetus development of the CNS andor other organs Congenital Rubella Syndrome Small birth weight blindness hearing loss mental retardation heart problems Infection lasts for monthsyears in the newborn Vaccine highly effective MMR Features for Measles and Rubella Dlxease M23312 Rubella Eausallva organlxmm Mmsles mus Ruhulla Ims Mon Cummer Mode Dmplel mmatl Dmle mmacl n mmmmma Wrulenm Facial Syncylium formation in Musts Iiwhihmnn abxlltv m supple LMI tifmimu Inductinn ul apopium ant damage in vascular enduxhelnim CultumDiagnoxis mm or 13le acute Acute lgM mm tomvaiesmm lgG convaiamni IgG Prwenlian Live ailenuaxad Live altenlialsd Ncrmc lMVlRl accmc szl Yrealmem 1w animals mamm A a mlmiallcs rm L a Dixtinguixhing features Slam on man mead Mllder ml mu lmls 1139 me mm to whole bod lasls approximately 5 days we a week Virus Infections of the Skin Vesicles Vesicular or pustular rash elevated lesions filled with fluid Smallpox Human Pox virus Cold Sores Human simplex 1 and 2 Chickenpox Human Herpesvirus3 Chickenpox Varicella Zoster Common virus decreasing disease in the USA due to effective childhood vaccine Benign disease with life long immunity Lifethreatening forimmunocompromised individuals Recuperation can result in life long benign Varicellazoster virus latency May reemerge as shingles skin lesion Should we vaccinate adults Chickenpox virus in the body virai ihtecticih thruugh aerciscii druplet systerhic ihtecticih 9 icicai ihtecticih in lymph HDdES citthe neck 9 lymphucyte assciciated VirEmia Fever rhaiaise 9 Spread thruughuut the budy 9 shed iri respiratciry tract secreticiris arid Skin yesicies small blisters cit iearfiuid 9 Recovery With Virus latency ih hedrcihs 9 Life lung immu ity May rEcEmErgE as shingles and spread tci cithers skin vesicular iesicihs Chicken pox reemerges as Shingles Causes stress X raytreatments drug therapy or a developing malignancy or Vancellarzustervims reemergence as shingles Smallpox A disease with an interesting history Very infectious viral disease epidemic The disease has been eliminated due to worldwide vaccine program Vaccinia a Jennerian vaccine Named for Edward Jenner 1796 The virus has been preserved in government labs by agreement at CDC in Atlanta and in Russia Considered a bioterrorism agent Features ofChickenpox and Smallpox mm mm m Virus Infections of the Eye Herpesvirus Keratitisr Human simplex 1 Chlamydial infection of the eye Chlamydia trachomatis causes trachoma and can lead to blindness Warts and Papillomas Mostly a benign viral infection Nearly everyone is infected Contact transmission fomite transmission Dif ferent virus types Pantar warts HPV1 Fat warts HPV3102849 Genital Warts HPV 6161831 Common warts L 10
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