Class Note for CHEM 490 at UMass(28)
Class Note for CHEM 490 at UMass(28)
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This 18 page Class Notes was uploaded by an elite notetaker on Friday February 6, 2015. The Class Notes belongs to a course at University of Massachusetts taught by a professor in Fall. Since its upload, it has received 19 views.
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Date Created: 02/06/15
Outline Fri 13009 Noncovalen39r Interactions Ch 1 Wha r s rabilizes The DNA double helix Covalen r bonds delermine sequence Noncovalen r inlerac rions much weaker Elec rros ra ric phospha res EFFec r of dielec rric Hydrogen bonds base pairs Dis rance amp geome rry Compeli rion wilh waler Van der Waals base slacking Hydrophobic inlerac rions base slacking En rropic eFFec r Reasoning abou r impor rance ro slabili ry Reminder all lhis happens in lhe cell Chemical proper ries de rermine Func rion DNA example 4 bases Form 2 base pairs via H bonds AT amp GC Same sizeshape r in ro double helix Sequence encodes inForma rion Unique basepairing makes copying possible Today gtNoncovalen r in rerac rions eg H bonds Weaker rhan covalen r in rerac rions Makes assemblydisassemny possible in mild condi rions eg For copying DNA Many roge rher s rabilize unique 3D s rruc rures eg DNA double helix gtAcidbase chemis rrv 02gt 966x m acczm mzx KUEdLUOj pue uewamg 39H 39M 00 Q Mama um 39Kuswaumm Covalent bonds Noncovalent interactions 0 H H 439 lt9 C39e H3N CH Hc H H Chargecharge Interaction 40 to 200 kJ mol 1 I H H C 0 N A H H H Hydrogen bond H H 2 to 20 kJ mol 1 van der Waals interaction 04 to 4kJ mol 1 CH H C 2 2 Hydrophobic interaction Horton 3 to 10 kJ mol 1 O 439 69 C H3N O Chargecharge interaction 40 to 200 kJ mol391 Figure113 i ii l f f f iquot o o o O O 0 P o O o O o o Unnumbered figure pg 8 Biochemistry Sixth Edition 6 2007 W H Freeman and Company Guanine Cytosine n O n l l z o z o o o Unnumbered figure pg 10 Biochemistry Sixth Edition re 2007 w HFrEeman and Company C H H C 4 l H H H H C H H C lI H H van der Waals interaction 04 to 4 kJ mol 1 Figure 1 inch 8m 51 1 Mi I NH2 NHz H 0 O N N kaH l cm N n ox 39H 4 T H Hydrophobic effect Hydrophobic interactions NOT a hydrophobic bond Hydrophilic Hydrophobic amphipathic amphiphilic examples surfactant detergent lipid 39 Hydrophilic quothead group Hydrophobic alkyl group do quotFlickering clustersquot of H20 Il molecules in bulk phase amp Highly ordered H20 molecules form cages around the hydrophobic alkyl chains Dispersion of lipids in H20 Each lipid molecule forces surrounding H20 molecules to become highly ordered Clusters of lipid molecules Only lipid portions at the edge of the cluster force the ordering of water Fewer H20 molecules are ordered and entropy is increased Micelles All hydrophobic groups are sequestered from water ordered shell of H20 molecules is minimized and entropy is further increased NH2 NHz H 0 O N N kaH l cm N n ox 39H 4 T H Which noncovalent interaction contributes most to DNA or protein stability a H bonds b Hydrophobic effect c Chargecharge d van der Waals For each one why or why not l r medically imporfunf 39 processes donquot 6 occur in 1 simple homogeneous 539 solutions Dzmnl Goodsell39s depmlon at E Cali coll Outline Fri 13009 Acidbase chemis rr39y of ionizable gr39oups Ch 12 Signi cance of ch1 deducing species presen r HendersonHasselbach equa rion pH ex rremes disrup r s rruc rures of DNA pro reins Buffer solu rions kaH HltN I NAN H2 Guanine G Unnumbered figure pg 15 Biochemistry Sixth Edition 0 2007 WHFreeman and Company o N pKa 97 Hltf jl H N N NH2 3amp03 275 0 06 E I 2204 g39g E1302 LI 0 I I I 7 8 9 10 Figure116
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