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This 1 page Class Notes was uploaded by Snehi Christian on Tuesday February 2, 2016. The Class Notes belongs to BIO 150 at a university taught by Bethany Bowling in Winter 2016. Since its upload, it has received 23 views.
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Date Created: 02/02/16
Module 60 GWAS- Genome –wide association studies it is a type of research study that deals with DNA technologies into a large scale biomedical research project. The main aim of the GWAS is to tract the genetic variation that is related to a disease, condition or a trait. In GWAS two groups of individuals are studies one group of individuals has the disease or the interested phenotype while the other does not have the disease or the phenotype. DNA samples are taken from both the groups and are compared at Single-Nucleotide Polymerase (SNPs) they are single base difference in gene sequence .The SNPs was more often in the group of individuals with the disease or the phenotype than the group without the disease or the phenotype. In 2010 GWAS published a report that stated that individuals having a AA SNPs combination had the highest risk of hypertension and the ones having GG combination had the lowest risk. Gene Therapy- It is a procedure of introducing healthy gene sequence to cells which have mutated gene sequence. Vectors are modified viruses that has the correct gene sequence for the DNA to produce the correct protein. Gene therapy uses viral vectors for the gene transfer step. Transgenic Organisms are organisms that express the gene of interest or a foreign gene that would be required for producing specific proteins. We did a lab in which we transformed the E.coli bacteria using the Green Florescent protein (GFP) which glows under blue light and the transformed E.coli is the example of Transgenic organisms . A DNA sequence of each individual is differentiated using the short tandem repeats (STRs) every person as a 2- 5 base pair sequence that is repeated over and over again. The length of the sequence varies in a population. Bioremediation is a process in which genetically modified bacteria are used to clean up an environmental contamination. For example using a genetically modified bacteria to degrade the oil spill in an ocean. Genetically Modified Organisms (GMO) - They are organisms who have been given a gene for a different organism to express the effect of the inserted gene that is not found in the normal organism. Example Purple tomato a gene from snapdragon is inserted.
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