Neurobiology Week of Feb 1
Neurobiology Week of Feb 1 BIO 467
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This 2 page Class Notes was uploaded by Mikayla Huber on Wednesday February 3, 2016. The Class Notes belongs to BIO 467 at Arizona State University taught by Dr. Newbern in Fall 2016. Since its upload, it has received 7 views. For similar materials see Neurobiology in Biology at Arizona State University.
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Date Created: 02/03/16
Feb 1 Synaptic Transmission Definitions Electrical Synapses - Connexins A family of proteins that form gap junctions Neurotransmitters Transduce information across the synapse Neuromodulators Modulate the activity of neurons across long distances Hormones Released by glands into the blood and travel through the body Spatial Integration Summation of potentials from separate physical regions of the neuron Temporal Integration Summation of potentials occurring at various times Glutamate + 2+ An excitatory neurotransmitter that can act on ionotrophic receptors resulting in Na Ca y-Aminobutyric acid (GABA) an inhibitory neurotransmitter that can act on ionotrophic receptors resulting in Cl flow Feb 3 Neurotransmitters • Know the major classes of neurotransmitters and distinguishing characteristics regarding synthesis, anatomical source, signaling mechanisms, and receptor subtype. Types of Neurotransmitters Small Molecule Transmitters Acetylcholine – Biochemical Regulators – these control motor neuron/neuromuscular transmissions, autonomic regulation in the peripheral nervous system, and plasticity, wakefulness and reward in the central nervous system Choline Acetyltransferase (ChAT) Vesicular Acetylcholine Transporters (VAChT) Acetylcholinesterase (AChE) nicotinic Ach receptors (nAChR) muscarinic Ach receptors (mAChR) Glutamate – Biosynthesis – important transmitters for normal brain functions Glutaminase Vesicular Glutamate Transporter (VGLUTs) Excitatory Amino Acid Transporters (EAATs) Glutamine Synthetase Glutamate-glutamine cycle GABA – Biosynthesis – the primary inhibitory neurotransmitters Glutamic Acid Decarboxylase (GAD) Vesicular Inhibitory Amino Acid Transporter (VIAAT or VGAT) GABA Transporter Dopamine – these mediate complex behaviors GPCRs Serotonin – regulate many brain functions in the CNS and PNS Tryptophan-5-hydroxylase Vesicular Monamine Transporter (VMAT) Serotonin Transporter (SERT) 5-HT receptors Peptide Neurotransmitters Opioids Substance P Nitric Oxide
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