New User Special Price Expires in

Let's log you in.

Sign in with Facebook


Don't have a StudySoup account? Create one here!


Create a StudySoup account

Be part of our community, it's free to join!

Sign up with Facebook


Create your account
By creating an account you agree to StudySoup's terms and conditions and privacy policy

Already have a StudySoup account? Login here

For the week of February 1, 2016

by: Orlando Notetaker

For the week of February 1, 2016

Marketplace > Purdue University > Biomedical Sciences > > For the week of February 1 2016
Orlando Notetaker
View Full Document for 0 Karma

View Full Document


Unlock These Notes for FREE

Enter your email below and we will instantly email you these Notes for Polymers

(Limited time offer)

Unlock Notes

Already have a StudySoup account? Login here

Unlock FREE Class Notes

Enter your email below to receive Polymers notes

Everyone needs better class notes. Enter your email and we will send you notes for this class for free.

Unlock FREE notes

About this Document

Class Notes
polymers, Biomaterials, Biology, Engineering




Popular in Polymers

Popular in Biomedical Sciences

This 5 page Class Notes was uploaded by Orlando Notetaker on Sunday February 7, 2016. The Class Notes belongs to at Purdue University taught by in Spring 2016. Since its upload, it has received 13 views. For similar materials see Polymers in Biomedical Sciences at Purdue University.


Reviews for For the week of February 1, 2016


Report this Material


What is Karma?


Karma is the currency of StudySoup.

You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!

Date Created: 02/07/16
Lecture'5 Tuesday,'February'2,'2016 5:58'PM Really,'really'hydrophobic,'it'will'precipitate'at'lower'temperatures Amine'group'dissolves'at'low'pH' ::>'hydrogen'ion'binds'and'it'becomes'more' hydrophilic pH'sensitive'membrane'systems ! Targeted'delivery'to'certain'organs'in'the'body'(eg.'Intestines'vs.'stomach) PVC': poly(vinyl'chloride)'is'used'to'make'blood'bag Artificial' : has'some'sort'of'function'to'replace'a'normal'thing'in'the'body Synthetic': man:made Stocking'is'the'most'flexible'polymer Copolymer': two'different'monomers'as'composites'to'a'polymer Silicone'is'hydrophobic,'but'not'entirely,'this'helps'it'hold'water.'It'is'also'porous' which'helps'as'well. Screws'in'body'are'often'PLA': polylactic'acid'because'it'is'biodegradable Skin'grafts'are'often'created'from'taking'skin'cells'from'host'and'culturing'host'cells.' Takes'time'and'money Albumin'carries'fatty'acid'and'non'water'soluble'stuff'in'blood To'prevent'clotting,'put'the'albumin'in'first'so'that'the'albumin'will'adsorb'to'the' surface'leaving'no'space'for'fibrinogen To'prevent'clotting,'put'the'albumin'in'first'so'that'the'albumin'will'adsorb'to'the' surface'leaving'no'space'for'fibrinogen Platelets'in'blood'are'round,'but'when'they'stick'to'the'surface,'they'spread'out' physically'with'extensions Only'one'thrombus'forms'because'the'surface'becomes'dirty'and'fibrinogen'can'bind' to'an'unclean'surface Prevention'of'platelet'activating'protein'adsorption'by'coating'the'surface'with' something'(like'albumin)'so'that'fibrinogen'cannot'bind'to'it.'This'is'called'passivation. Drug'eluting'stent:' delivers'drug'over'time'to'prevent'restenosis Coronary'stent': developed'by'a'surgeon'who'then'sold'the'idea'to'J'and'J Lecture'6 Thursday,$February$4,$2016 6:21$PM FDA$cares$about$safety$and$efficacy.$FDA$does$not$regulate$price. Dr.$Harvey$Washington$Wiley$was$the$first$FDA$Commissioner Born$in$Indiana.$Professor$at$Purdue$University. Be$wary$of$the$Placebo$effectB$ this$has$a$40%$effectiveness Patent$medicine$ Bclaims$to$be$a$cure,$but$cannot$disclose$methods$due$to$"under$ patent" Drug$delivery$systems$=$drug$+$(everything$else$/$excipients) Excipients$B GRAS$(generally$recognized$as$safe)$materials GRAS ! These$don't$bother$the$FDA$e.g.$sucrose,$water FDA$approves$the$marketed$drug,$not$the$marketed$polymer$or$something FDA$will$approve$the$dose$up$to,$but$not$greater$than.$If$you$get$approved$for$80$mg$ and$want$to$make$60$mg,$ok.$If$you$want$to$make$500$mg,$big$deal. Precision$Medicine$and$Predictive$Medicine Abuse$deterrent$formulation$ B a$way$to$deter$addicts$from$abusing$prescription$drugs Rationale$of$Controlled$Drug$Delivery$Systems ! If$I$take$7$days$worth$of$drugs$a$day,$the$drug$concentration$increases$at$the$ same$time$(potentially$over$toxic$levels),$but$it$will$not$be$sustained$for$very$ long. Enzyme$inductionB$if$you$take$the$same$drug$over$and$over,$body$produces$more$ ! If$I$take$7$days$worth$of$drugs$a$day,$the$drug$concentration$increases$at$the$ same$time$(potentially$over$toxic$levels),$but$it$will$not$be$sustained$for$very$ long. Enzyme$inductionB$if$you$take$the$same$drug$over$and$over,$body$produces$more$ enzyme$to$degrade$it$faster,$then$must$take$more$drug$to$have$the$same$effect Therapeutic$Index$(TI) B$the$amount$of$pills$you$can$take$before$toxicity Barbiturates$(sleeping$pills$ 2B7 Digitoxin$B 1.5 Penicillin$>$100 Risk$benefit$ratio$or$benefit$risk$ratio The$therapeutic$index$is$the$between$the$toxic$level$and$lowest$minimum$effective$ level Transdermal$Patch ! Occlusive$backing ! Drug$reservoir ! RateBcontorlling$membrane ! Contact$adhesive ! Protective$linear 2.Drug$delirvery$module Rate$controller Energy$source Delivery$portal(exit) Reservoir 3.platform With$a$transdermal$patch,$the$adhesive$(maintains$drug$deliery$to$final$place)$is$the$ platform Note:$osmotic$pressure$depends$on$concentration.$So$a$million$monomers$has$a$ higher$osmotic$pressure$than$1$polymer. Diffusion$is$due$to$random$motion Note:$osmotic$pressure$depends$on$concentration.$So$a$million$monomers$has$a$ higher$osmotic$pressure$than$1$polymer. Diffusion$is$due$to$random$motion Zero$order$BB(analogy)$keep$spending$enough$money$that$you$reach$$0$at$the$end$of$ the$month First$order$kinetics$BB(analogy)$only$spend$a$specific$percentage$(eg$3.3%)$of$the$ remaining


Buy Material

Are you sure you want to buy this material for

0 Karma

Buy Material

BOOM! Enjoy Your Free Notes!

We've added these Notes to your profile, click here to view them now.


You're already Subscribed!

Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'

Why people love StudySoup

Steve Martinelli UC Los Angeles

"There's no way I would have passed my Organic Chemistry class this semester without the notes and study guides I got from StudySoup."

Jennifer McGill UCSF Med School

"Selling my MCAT study guides and notes has been a great source of side revenue while I'm in school. Some months I'm making over $500! Plus, it makes me happy knowing that I'm helping future med students with their MCAT."

Bentley McCaw University of Florida

"I was shooting for a perfect 4.0 GPA this semester. Having StudySoup as a study aid was critical to helping me achieve my goal...and I nailed it!"

Parker Thompson 500 Startups

"It's a great way for students to improve their educational experience and it seemed like a product that everybody wants, so all the people participating are winning."

Become an Elite Notetaker and start selling your notes online!

Refund Policy


All subscriptions to StudySoup are paid in full at the time of subscribing. To change your credit card information or to cancel your subscription, go to "Edit Settings". All credit card information will be available there. If you should decide to cancel your subscription, it will continue to be valid until the next payment period, as all payments for the current period were made in advance. For special circumstances, please email


StudySoup has more than 1 million course-specific study resources to help students study smarter. If you’re having trouble finding what you’re looking for, our customer support team can help you find what you need! Feel free to contact them here:

Recurring Subscriptions: If you have canceled your recurring subscription on the day of renewal and have not downloaded any documents, you may request a refund by submitting an email to

Satisfaction Guarantee: If you’re not satisfied with your subscription, you can contact us for further help. Contact must be made within 3 business days of your subscription purchase and your refund request will be subject for review.

Please Note: Refunds can never be provided more than 30 days after the initial purchase date regardless of your activity on the site.