Genetics Week One
Genetics Week One BIOL/PBIO 3333
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This 2 page Class Notes was uploaded by Lauran Notetaker on Friday February 12, 2016. The Class Notes belongs to BIOL/PBIO 3333 at University of Oklahoma taught by Dr. Jim Thompson in Winter 2016. Since its upload, it has received 12 views. For similar materials see Genetics in Biology at University of Oklahoma.
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Date Created: 02/12/16
January 20, 2016 I. General info II. The “Gene” Concept A. Biochemical deﬁnition B. Transmission deﬁnition C. Historical Perspective: What is a gene? Final Exam Thursday, May 12 8-10am Action Center: Wagner Hall 140/145 Tuesdays: 4-5:30pm, Wednesdays: 2:30-4:30pm January 22, 2016 I. Intro II. The “Gene” Concept A. Biochemical deﬁnition B. Transmission deﬁnition C. Historical Perspective: What is a gene? III.Gene Transmission A. Intro to Genome organization B. Mitosis 1. Overview 2. Stages C. Meiosis 1. Overview 2. Prophase I II. A. DNA mRNA polypeptide Precursor A B C Product The “Central Dogma” of molecular biology over accumulation of “B” will affect phenotype, not being converted to “C” from a DNA mutation C. Mendelian genetics (Gregor Mendel) was not recognized until almost two decades after his death Early ideas about transmission Pangenesis - Greek views (Hippocrates, Anaxagoras, Aristotle) - Form (e.g. “gemmules”) provided by male - female provided raw material or had negligible role Spontaneous generation - preformationism - spermatists vs ovists, humunculus - epigenesis - gradual elaboration of form after fertilization - start as egg Charles Darwin (1809-1882) Gregor Mendel (1822-1884) Garden Pea 1. Lucky in choice of traits to study 2. Approached the problem quantitatively 3. Established criteria for experimentation Mendelian Laws *No rules are laws haploid (n) - unfertilized eggs and sperm Some chromosome landmarks Euchromatin - coding “working true or normal” heterochromatin - noncoding around centromere, more structural Centromere positions - 2 arms (p&q) - metacentric (M) in the middle; p and q are about the same - acrocentric (A) one arm is longer than the other - telocentric (T) close to the end, looks like an i satellites - the nucleolar organizer region (nucleolus), the site of ribosomal RNA synthesis
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