BIOL 5600 Notes 1/20/16
BIOL 5600 Notes 1/20/16 BIOL 5600
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This 3 page Class Notes was uploaded by LaurenC on Monday February 15, 2016. The Class Notes belongs to BIOL 5600 at Auburn University taught by Dr. Mendonća in Winter 2016. Since its upload, it has received 35 views. For similar materials see Biomedical physiology in Biology at Auburn University.
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Date Created: 02/15/16
Biomedical Physiology 1/20/16 Recap -What’s going on in/out of the cell -Unequal distribution of solutes -Structures and movement -Processes that help movement -Change in permeability due to information transfer Membrane receptors Transfer of cell information: 4) Intracellular receptors o Steroids -Lipid soluble >Lipid bilayer binds to intracellular receptors; transcription starts and has a genomic affect -Cholesterol based -Causes production of new protein The membrane potential -The difference in charge between the inside and outside of the cell INSIDE CELL INSIDE CELL Net charge is - Net charge is + Low NA+ (15 mM) High NA+ (150 mM) High K+ (150 mM) Low K+ (5 mM) Low Cl- (4mM) High Cl- (110 mM) Low Ca2+ (.1mM) High Ca2+ (1.2 mM) High proteins – (161 mM) Low Pr- (4.5 mM) -Creates electrochemical equilibrium because of the huge amount of negative charge (A-) (A-) -Everything is in equilibrium -Not chemical equilibrium, electrochemical equilibrium -Stable resting potential -Electrochemical equilibrium >DONAN equilibrium -When the cell is at rest, membrane potential tends to be negative >The resting membrane potential -All cells have relative distribution like this -A lot of cells are always at a resting potential -Lots of NA+/K+ pumps throughout the cell membrane in order to keep the relative distribution -Movement of these K+ ions is a main influence on resting potential >Because more K+ passive K+ channels/membrane than passive Na+ channels Excitable cells (neurons, muscle cells) -Change membrane potential -Change relative concentration of ions in/out of the cells -They don’t have passive channels -They have chemically and voltage gated/regulated channels -When excitation comes, when membrane potential changes: >Membrane voltage changes >Membrane charge changes >”All bets are off” Different cells have different resting potentials -You can calculate the resting potentials if you know the relative concentration of ions inside and outside of the cell -You do this by use of the Goldman equation [I= concentration] [R=8.314 (gas constant)] [P=Permeability of ion] [T=temp (K)] [F=Faraday’s constant (Colum’s/mole)] [EMF= electro motive force (voltage)] o Equation: EMF=RT/F ln[(P[K] ou/[K] )+(P[Na+] out/[Na+] )+ (P[Cl-] /P[Cl-] ou)] The Nernst equation is the idea that K+ is the key thing -(RT/zF) is a constant like normal body temperature o Equation: in out EMF=[(RT/zF) log (K /K )] Ex. (100 in/ 100 out) =1 log of 1 = 0 -If you had more K+in the extracellular than intracellular fluid, then it would be less negative, and more positive. It would be depolarized. Ex. depolarized (100 in/ 1000 out) =.1 results in less negative Ex. hyperpolarized (1000 in /100 out) =10 results in more negative
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