BIOL 5600 Notes 1-21-16
BIOL 5600 Notes 1-21-16 BIOL 5600
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This 2 page Class Notes was uploaded by LaurenC on Tuesday February 16, 2016. The Class Notes belongs to BIOL 5600 at Auburn University taught by Dr. Mendonća in Winter 2016. Since its upload, it has received 38 views. For similar materials see Biomedical physiology in Biology at Auburn University.
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Date Created: 02/16/16
BIOL 5600 1/21/16 Membrane potential (MP) -Negative resting MP -Usually stable Goldman equation -Reduces to Nernst equation -K+ is the key A normal cell with an electrode in it that is connected to a measuring device measures a value that can be graphed If the relative concentration of ions is stable, the resting MP is stable When you start changing the concentration, resting MO changes and becomes unstable Hyperkalemia -When increased level of extracellular K+ -Excess K+ in plasma and thus, more in ECF/ interstitial fluid o You are more likely to initiate the action potential (with little stimulation) >Symptoms include: -Palpitations -Hyperventilation -Affects cardiac muscle cells and makes them less likely to repolarize (become more negative again) Hypokalemia -Opposite of hyper -Less K+ in the extracellular fluid than normal -More relative concentration of K+ intracellular -Promoting K+ to go out of the cell -Not a change in relative concentration, change in the charge -Less likely to initiate action potential *RMP is more negative, less positive. This state is called hyperpolarization. o Initial -Muscle weakness -Muscles not contracting effectively -Constipation o Severe -Respiratory depression -Muscles not contracting effectively (cramps) -Can be cause by: >Diarrhea >Vomiting >Sweating Chapter 2 and 4 material begins: *Threshold is the voltage it will take to initiate an action potential in a particular cell Action potential- an all or nothing event 1) *Start action potential -Voltage regulated (VR) Na+ channel opens 2) Depolarization -VR Na+ channels close, K+ channels open -Causes K+ to get pushed out o the cell -Cell becomes more negative -Results in repolarization Graded potential -EPSP (excitatory post synaptic potential) -When you have CR (chemically regulated) /gated Na+ channels -More positive -Less polarized -Will change the charge inside the membrane to more positive *If VR K+ channels are slow to close, too much K+ leaves the cell -It gets back up to resting MP through Na+/ K+ pumps Action potential - Action of voltage regulated channels - Depolarizing events - You generated a signal, there will be a response/consequence Chapter 4 stuff begins: Neurons- to explain the process of action potentials -Structures: -Dendrite (post synaptic side) -Cell body (post synaptic side) -Axonal synaptic branches and axonal synaptic buttons/terminal (presynaptic side) >Form synapses with other neurons *The space between the axonal terminal and the dendrite/cell body is called the synaptic cleff o The extent of pump is variable. - dependent on the strength of the stimulation
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