BIOL 5600 Notes 2/2/16
BIOL 5600 Notes 2/2/16 BIOL 5600
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This 2 page Class Notes was uploaded by LaurenC on Wednesday February 17, 2016. The Class Notes belongs to BIOL 5600 at Auburn University taught by Dr. Mendonća in Winter 2016. Since its upload, it has received 44 views. For similar materials see Biomedical physiology in Biology at Auburn University.
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Date Created: 02/17/16
BIOL 5600 2-2-16 T-tubule -Transverse tubule -Holds Ca+2 -Space around is called terminal cisternae >20% of Ca+2 comes from outside the cell >80% of Ca+2 comes from the terminal cisternae VR Ca+2 pumps -To pump Ca+2 back out of cell -For re-establishment Excitation -Contraction coupling Release of neurotransmitters Series of proteins that form snare complex 1) Synaptobrevin -On synaptic vesicle surface 2) Primary proteins -Syntaxin and snap 25 -Coming off of the axonal terminal membrane -Oriented inwardly 3) Synaptotagmin -Between synaptic vesicle and axonal terminal -Ca+2 sensitive *Snare complex is formed hen Synaptotagmin is induced by Ca+2 -Results in rupture of synaptic vesicle and endocytosis of Ach -Binding of Ach sends Na+ into the cell *There is always Achase in neuromuscular junctions Detail of overall process -What happens at the T-tubules A specialized compound that causes release of Ca+2 from terminal cisternae -Voltage sensitive protein called DHP receptor >Along the T-tubule >Mechanically regulated VR Ca+2 channel beside t-tubule called RyR (Rynodine receptor) Once released, Ca+2 binds in cell to troponin and rotates tropomyosin out of the way causing myosin heads (an ATPase)to bind actin and ATP -Stored potential energy -Low energy 1) Myosin heads pop up out of low energy and grab actin 2) Binding /Splitting of ATP 3) Power stroke 4) Myosin head binds new ATP -Back down to low energy Muscle fiber -Some initial energy reserves o Inside muscle fiber 1) Myosin head- ATP -Each head has an ATP molecule associated with it -Powers few seconds of contraction 2) Creatine phosphate -30 seconds of contraction *Creatine NP (high energy group attached) donated to Pn ADP to form ATP 3) Glycogen -Storage form of glucose -Can be readily metabolized to form ATPs (Because it doesn’t come from anywhere) -Can go through metabolic pathways to make ATP by becoming glucose (C6H12O6) -Length depends on O2 levels in cell *Glycogen>glucose>glycolysis (splitting of glucose)>2 pyruvate molecules (C3H6O3) Anaerobic metabolism -No O2 needed thus far -Krebs cycles produces a lot of ATP