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MCB2000- Lecture notes, week of 2/15

by: Kelsi Rau

MCB2000- Lecture notes, week of 2/15 MCB2000

Marketplace > University of Florida > Microbiology > MCB2000 > MCB2000 Lecture notes week of 2 15
Kelsi Rau

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About this Document

These notes cover everything addressed in the lecture of the week of 2/15, that will be on Exam 3.
Dr. Asghari
Class Notes
micro, Microbiology, Exam 3, notes, Lecture
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This 3 page Class Notes was uploaded by Kelsi Rau on Friday February 19, 2016. The Class Notes belongs to MCB2000 at University of Florida taught by Dr. Asghari in Spring 2016. Since its upload, it has received 25 views. For similar materials see Microbiology in Microbiology at University of Florida.


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Date Created: 02/19/16
Friday, May 20, y Exam 3 Lecture Notes Terms Used in the Study of Infectious Diseases Parasite: live off other resources, part of life, they always benefit from the other  ­ organism, includes harming the other ­ Colonization: when the actual organism establishes and grows on your body Infectious Diseases: diseases caused by microbial organisms, (liver, kidney disease  ­ not infectious, nothing to do with microorganism), disease­ some functions of your  system have been impaired and are not functioning normally  ­ Pathogen: only a small fraction of microorganisms cause disease as pathogens ­ Pathogenic: some are opportunistic, may not cause disease in you, but may cause it  in another person, healthy people are not usually affected by it, some people are  immunocompromised individuals­ all people can be exposed but these people will get sick easily (ex: HIV) ­ Immunologically compromised host: lower resistance to infection  ­ Systemic infection: transfer through the blood ­ Latent infection: remains with you for a long period of time, microorganisms don ’t  leave the tissue, no symptoms are observed, (ex: herpes virus­ can never leave you  once gotten, every once in a while you have a flare up, rashes, can take medicine but cannot cure) (ex: syphilis­ bacteria infection, causes problems and goes away but  can come back again and again if not treated with antibiotics), some cases latency is  forever­ there is no cure Virulence Factors and Types of Infection Acute: short but severe, over soon, doesn't kill you right away, goes away soon,  ­ inflammation is good here­ if quick and efficient 1 Friday, May 20, y ­ Chronic: mild form of the infection for the long term, stays with you for a long period  of time, damages your body as time goes by, if you have this­ the microbes are inside you in different parts­the immune system is constantly following them­inflammation  happens in different parts of your body­ this is not good within chronic infection­ causes damages without you knowing it,  ­ body can produce antibodies against your own body and your own DNA ­ Fulminating Infection: with great intensity, (ex: meningitis), grows so fast and  multiplies very quickly, very dangerous ­ Latent: can be lifetime with no symptoms ­ Nosocomial: from healthcare facility, comes from staff­patients, old microbes can be  moving and given to someone else ­ Koch ’s Postulate: 1 microbe —> 1 disease, some exceptions; multiple microbes can  be involved in the same infection, only applied for infectious diseases­ not all disease ­ Pyogenic: puss­forming, different than Pyrogenic­ fever inducing molecules ­ Sepsis: microbes grow and multiply and spread through your blood, very serious  condition, the toxins of microbes spreading in the blood or the tissue, can lead to.. ­ Septic Shock: very serious, blood pressure drops­ collapse ­ Septicemia: gram negative is more severe, when microbes are killed­ gram negative  release endotoxins­ outer membrane­LPS, own consequences­ inflammation­  bleeding­ hemorrhage­ fever, has to be treated with endotoxin treatment and bacterial treatment   ­ Zoonotic disease: primarily transferred from animals to humans Virulence Factors ­ Enzymes, pili, fimbrae, flagella, plasmid, endotoxins, exotoxins, cell wall, capsule,  glycocelix 2 Friday, May 20, y ­ Exotoxins are  proteins produced and secreted that damage the cell ­ Endotoxins are part of the gram negative outer membrane ­ Protein A: binds to immune system components, prevent phagocytosis  ­ Enzymes: coagulase, hyaluronidase­ dissolves connective tissue­ allows spread of  the bacteria in the body ­ Streptokinase: binds and activates the production of plasmid ­ Coagulase: insulate the bacteria so the immune system cannot get to it, protects the  bacteria by creating a gel blood ­ Leukocidins: white blood cells  ­ Super antigens: molecules that act beyond a normal infection, treat the body with  multiple infections, results in overreaction by the immune system, results in shock  and self­inflicted wounds Protease: kill antibody, don ­ ’t allow immune system to function properly ­ anything that can grow without any damage is a virulence factor ­ 3


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