MCB2000- Lecture notes, week of 2/15
MCB2000- Lecture notes, week of 2/15 MCB2000
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This 3 page Class Notes was uploaded by Kelsi Rau on Friday February 19, 2016. The Class Notes belongs to MCB2000 at University of Florida taught by Dr. Asghari in Spring 2016. Since its upload, it has received 25 views. For similar materials see Microbiology in Microbiology at University of Florida.
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Date Created: 02/19/16
Friday, May 20, y Exam 3 Lecture Notes Terms Used in the Study of Infectious Diseases Parasite: live off other resources, part of life, they always benefit from the other organism, includes harming the other Colonization: when the actual organism establishes and grows on your body Infectious Diseases: diseases caused by microbial organisms, (liver, kidney disease not infectious, nothing to do with microorganism), disease some functions of your system have been impaired and are not functioning normally Pathogen: only a small fraction of microorganisms cause disease as pathogens Pathogenic: some are opportunistic, may not cause disease in you, but may cause it in another person, healthy people are not usually affected by it, some people are immunocompromised individuals all people can be exposed but these people will get sick easily (ex: HIV) Immunologically compromised host: lower resistance to infection Systemic infection: transfer through the blood Latent infection: remains with you for a long period of time, microorganisms don ’t leave the tissue, no symptoms are observed, (ex: herpes virus can never leave you once gotten, every once in a while you have a flare up, rashes, can take medicine but cannot cure) (ex: syphilis bacteria infection, causes problems and goes away but can come back again and again if not treated with antibiotics), some cases latency is forever there is no cure Virulence Factors and Types of Infection Acute: short but severe, over soon, doesn't kill you right away, goes away soon, inflammation is good here if quick and efficient 1 Friday, May 20, y Chronic: mild form of the infection for the long term, stays with you for a long period of time, damages your body as time goes by, if you have this the microbes are inside you in different partsthe immune system is constantly following theminflammation happens in different parts of your body this is not good within chronic infection causes damages without you knowing it, body can produce antibodies against your own body and your own DNA Fulminating Infection: with great intensity, (ex: meningitis), grows so fast and multiplies very quickly, very dangerous Latent: can be lifetime with no symptoms Nosocomial: from healthcare facility, comes from staffpatients, old microbes can be moving and given to someone else Koch ’s Postulate: 1 microbe —> 1 disease, some exceptions; multiple microbes can be involved in the same infection, only applied for infectious diseases not all disease Pyogenic: pussforming, different than Pyrogenic fever inducing molecules Sepsis: microbes grow and multiply and spread through your blood, very serious condition, the toxins of microbes spreading in the blood or the tissue, can lead to.. Septic Shock: very serious, blood pressure drops collapse Septicemia: gram negative is more severe, when microbes are killed gram negative release endotoxins outer membraneLPS, own consequences inflammation bleeding hemorrhage fever, has to be treated with endotoxin treatment and bacterial treatment Zoonotic disease: primarily transferred from animals to humans Virulence Factors Enzymes, pili, fimbrae, flagella, plasmid, endotoxins, exotoxins, cell wall, capsule, glycocelix 2 Friday, May 20, y Exotoxins are proteins produced and secreted that damage the cell Endotoxins are part of the gram negative outer membrane Protein A: binds to immune system components, prevent phagocytosis Enzymes: coagulase, hyaluronidase dissolves connective tissue allows spread of the bacteria in the body Streptokinase: binds and activates the production of plasmid Coagulase: insulate the bacteria so the immune system cannot get to it, protects the bacteria by creating a gel blood Leukocidins: white blood cells Super antigens: molecules that act beyond a normal infection, treat the body with multiple infections, results in overreaction by the immune system, results in shock and selfinflicted wounds Protease: kill antibody, don ’t allow immune system to function properly anything that can grow without any damage is a virulence factor 3
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