BIOE 1010 Week 8 Notes
BIOE 1010 Week 8 Notes BIOE 1010
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This 2 page Class Notes was uploaded by Sara Littlejohn on Friday February 26, 2016. The Class Notes belongs to BIOE 1010 at Clemson University taught by Dr. Vladimir Reukov in Spring 2016. Since its upload, it has received 36 views. For similar materials see Biology for BioEngineers in Bioengineering at Clemson University.
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Date Created: 02/26/16
Module 5-1 Nucleotides, DNA Structure and Replication 2/24/2016 Nucleotides DNA and RNA are polynucleotide chains Nucleotides contain a base (B), sugar (S), and a phosphate group (P) The nitrogen-containing bases come from two cyclic chemical compounds o Pyrimidine Cytosine (Found in RNA and DNA) Thymine (Found in DNA only) Uracil (Found in RNA only) o Purine Adenine Guanine There are two kinds of pentoses (sugars) o Ribose (Found in RNA) contains 1 more oxygen than deoxyribose Ribonuecleotides: A, G, U, C o Deoxyribose (Found in DNA) Deoxyribonucleotides: A, G, T, C Nucleotides are joined together by a phosphodiester linkage o This is between the 5’ –OH of one pentose and the 3’ –OH of the next and it gives each strand a specific orientation 5’ 3’ RNA is a SINGLE CHAIN DNA is a DOUBLE CHAIN (DOUBLE HELIX) Complementary base pairs: o A-T Be able to complete a o G-C sequence of nucleotides o This enables the base pairs to given a template. be packed in the interior of the sugar-phosphate backbones The structure of DNA was “discovered” by James Watson and Francis Crick by X-ray diffraction analysis. DNA is wrapped around a protein core (Histone) and packed into chromosomes Replication DNA polymerase will synthesize a new strand and always add nucleotides in the 5’3’ direction. Replication Origin: the particular sequence where synthesis starts REPLICATION IS BIDIRECTIONAL
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