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Nucleic acid Structure

by: ChasePrater

Nucleic acid Structure 4510

Marketplace > Middle Tennessee State University > 4510 > Nucleic acid Structure
GPA 4.0

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About this Document

I was not in class on Tuesday april 5th, so this is just from Thursday april 7th. It is only this one page. Not too much was covered because we had a quiz and the fire alarm was pulled during class.
Biochemistry II
Dr. Ooi
Class Notes
biochem, Nucleic Acids, DNA
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This 1 page Class Notes was uploaded by ChasePrater on Sunday April 10, 2016. The Class Notes belongs to 4510 at Middle Tennessee State University taught by Dr. Ooi in Spring 2016. Since its upload, it has received 8 views.


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Date Created: 04/10/16
Chapter  24:  Nucleic  Acid  Structure   4-­‐7-­‐16   Central  Dogma:  DNA  to  RNA  to  Protein   Nucleotides  are  composed  of  nitrogenous  base,  a  sugar,  and  a  phosphate  group   Nucleoside:  nitrogenous  base  and  sugar  only   Pyrimidine  bases:   -­‐ Cytosine,  uracil,  and  thymine   Purine  Bases:   -­‐ Adenosine,  and  guanine   Tautomerization:   -­‐ Uracil  has  possible  lactam  and  lactim  forms   -­‐ Guanine  has  possible  keto  and  enol  forms   Functions   Polynucleotides:   -­‐ building  blocks  of  DNA  and  RNA   mononucleotides:   -­‐ most  have  ribose  with  a  phos  group  on  C5   -­‐ regulators  of  metabolism  (cAMP  and  cGMP)   -­‐ source  of  energy   -­‐ ATP  is  used  for  most  metabolic  processes   -­‐ GTP  is  used  in  protein  synthesis   -­‐ Only  phosphate  groups  transmit  energy   -­‐ Base  portion  is  signaling  part   DNA   Chargaffs  rule:  adenine  and  thymine  are  1:1  ration,  cytosine  and  guanine  are  1:1   ratio   Structure:   -­‐ two  strands  are  anti  parallel   -­‐ backbone  is  alternating  ribose  and  phosphates   -­‐ inside  is  base  pairs   -­‐ 3  possible  conformations:  A,  B,  and  Z   -­‐ B  is  the  most  common  conformation   -­‐ Z  is  the  only  left  handed  conformation  and  relevance  is  unknown   Torodial  DNA:   -­‐ negatively  charged  supercoiled  DNA   Palindrones:   -­‐ inverted  repeats  in  DNA  sequence;  they  cause  the  cruciform  tertiary   structure   Topoisomerases:   -­‐ they  control  supercoiling     -­‐ Type  1  breaks  one  strand  of  DNA   -­‐ Type  2  breaks  both  strands      


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