BioChemistry Week 11.1
BioChemistry Week 11.1 CHEM 3653 - 001
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This 2 page Class Notes was uploaded by Lauran Notetaker on Sunday April 10, 2016. The Class Notes belongs to CHEM 3653 - 001 at University of Oklahoma taught by Dr. Paul A. Sims in Winter 2016. Since its upload, it has received 9 views. For similar materials see Biochemistry in Chemistry at University of Oklahoma.
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Date Created: 04/10/16
March 29, 2016 Chapter 10: Lipids, membranes, and cellular transport Major functions of lipids: signaling have limited solubility in aqueous media Triacylglycerides: Glycerol esterﬁed with three fatty acids Unsaturated fatty acids contain one or more cis C=C double bonds saturated fatty acids contain no C=C double bonds. The ﬂuidity of fatty acids decreases as the chain length increases and the number of cis double bonds decreases. Sphingolipids built on amino alcohol sphingosine built from serine and palmitate major component of membranes glycans attached to sphingosine Cholesterol disrupts regular fatty acid chain esters are extremely apolar precursor to all steroids “Membranes are more mosaic than ﬂuid” Longer fatty acid chains and increased saturation of fatty acids in membrane lipids correlate with higher values of Tm Bacteria regulate fatty acid synthesis to relate membrane ﬂuidity to growth temperature March 31, 2016 Membrane Transport Processes Nonmediated Facilitated Active Thermodynamics of Membrane Transport: DeltaG = DeltaGnotPrime + RTln[C2]/[C1] = 0 + RTln [C2]/[C1] DeltaGnotPrime = -RTlnKeq = 0 Thermodynamics of Membrane Transport Thermodynamically favorable process coupled to transport against a concentration gradient Donnan Equilbrium - “poised to act” Ionophores are produced by bacteria to kill competing bacteria Valinomycin acts as a potassium ionophore symport -same direction antiport - opposite direction Hemolysin is a pore-forming ionophore Aquaporins - water channels that increase water transport in some tissues and maintain osmotic balance Gating - the switching between the conductive (open) and nonconductive (closed) channel conformations In cotransport the unfavorable movement of a substance through a membrane is coupled to the favoavle transport of another substance